Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Amelie M. Boespflug"'
Autor:
Mona Foth, Courtney C. Cavalieri, Lance D. Burrell, Stephanie L. Cutler, Conan G. Kinsey, Kajsa E. Affolter, Jill E. Shea, Amelie M. Boespflug, Kaitrin M. Rehbein, Alana L. Welm, Jeffrey T. Yap, Bryan E. Welm, Michael T. Seipp, Sophia S. Schuman, Jonathan Whisenant, G. Weldon Gilcrease, Amanda Truong, David H. Lum, Katrin P. Guillen, Courtney L. Scaife, Martin McMahon, Eric L. Snyder, Soledad A. Camolotto
Publikováno v:
Nature medicine
Pancreatic ductal adenocarcinoma (PDA) was responsible for ~ 44,000 deaths in the United States in 2018 and is the epitome of a recalcitrant cancer driven by a pharmacologically intractable oncoprotein, KRAS1–4. Downstream of KRAS, the RAF→MEK→
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa5167ad697961fda688a1d48e6be90
https://doi.org/10.1038/s41591-019-0367-9
https://doi.org/10.1038/s41591-019-0367-9
Autor:
Mona Foth, Soledad A. Camolotto, Stephanie L. Cutler, Jonathan Whisenant, Bryan E. Welm, Amanda Truong, Conan Kinsey, Kaitren Rehbein, Courtney L. Scaife, David H. Lum, Martin McMahon, Eric L. Snyder, Jeffrey T. Yap, Kajsa Afotler, Jill E. Shea, Courtney Cavalier, Michael T. Seipp, Katrin P. Gullien, Lance D. Burrell, Amelie M. Boespflug, Alana L. Welm
Publikováno v:
Cancer Research. 80:IA25-IA25
Although the RAF>MEK>ERK MAP kinase pathway is key to the development of many RAS-mutated cancers, efforts to target this pathway with pharmacologic inhibitors have failed to deliver clinical benefit to patients. Here we show that inhibition of RAS>R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e488905a9a6b4be13b50083768f8b48
https://doi.org/10.1158/1538-7445.mel2019-ia25
https://doi.org/10.1158/1538-7445.mel2019-ia25
Autor:
Alana L. Welm, Mona Foth, Courtney C. Cavalieri, Martin McMahon, Jill E. Shea, Stephanie L. Cutler, Conan Kinsey, Michael T. Seipp, Weldon Gilcrease, Kajsa E. Affolter, Bryan E. Welm, Eric L. Snyder, Kaitrin M. Rehbein, Jonathan Whisenant, Amelie M. Boespflug, Jeffrey T. Yap, Katrin P. Gullien, Lance D. Burrell, Soledad A. Camolotto, David H. Lum, Courtney L. Scaife
Publikováno v:
Molecular Cancer Research. 18:A45-A45
Pancreatic ductal adenocarcinoma was responsible for ~43,000 deaths in the USA in 2017 and is the epitome of a recalcitrant cancer driven by a pharmacologically intractable oncoprotein, KRAS. Although the clinical picture remains grim, the mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba407278220eac1a113ee4dae1d42260
https://doi.org/10.1158/1557-3125.ras18-a45
https://doi.org/10.1158/1557-3125.ras18-a45
Autor:
Courtney C. Cavalieri, Katrin P. Guillen, Courtney L. Scaife, Kajsa E. Affolter, Lance D. Burrell, Jill E. Shea, Sophia S. Schuman, Alana L. Welm, Martin McMahon, David H. Lum, Jonathan Whisenant, Amanda Truong, Soledad A. Camolotto, Mona Foth, Conan G. Kinsey, Eric L. Snyder, Stephanie L. Cutler, G. Weldon Gilcrease, Amelie M. Boespflug, Kaitrin M. Rehbein, Jeffrey T. Yap, Michael T. Seipp, Bryan E. Welm
Publikováno v:
Cancer Research. 79:2183-2183
Pancreatic ductal adenocarcinoma was responsible for ~43,000 deaths in the USA in 2017 and is the epitome of a recalcitrant cancer driven by an, as yet, pharmacologically intractable oncoprotein, KRAS. Although the clinical picture remains grim, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6099d95df30c9e6f536d7dd0bfc12bc9
https://doi.org/10.1158/1538-7445.am2019-2183
https://doi.org/10.1158/1538-7445.am2019-2183
Autor:
Kaitrin M. Rehbein, Mona Foth, Courtney C. Cavalieri, Stephanie L. Cutler, Sophia S. Schuman, Michael T. Seipp, Lance D. Burrell, Jill E. Shea, Alana L. Welm, Conan G. Kinsey, David H. Lum, Amelie M. Boespflug, G. Weldon Gilcrease, Jonathan Whisenant, Kajsa E. Affolter, Amanda Truong, Eric L. Snyder, Soledad A. Camolotto, Jeffrey T. Yap, Katrin P. Guillen, Courtney L. Scaife, Martin McMahon, Bryan E. Welm
Publikováno v:
Nature Medicine. 25:861-861
In the version of this article initially published, the label over the bottom schematic in Fig. 1a was “pH > 5.0”; it should have been “pH < 5.0”. Further, the original article misspelt the surname of Katrin P. Guillen as “Gullien”. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c36448df84a82584068bba3a66040df
https://doi.org/10.1038/s41591-019-0433-3
https://doi.org/10.1038/s41591-019-0433-3
Autor:
Conan G. Kinsey, Amelie M. Boespflug, Jill E. Shea, Michael T. Seipp, Soledad A. Camolotto, Katrin P. Guillen, Courtney L. Scaife, Martin McMahon
Publikováno v:
Cancer Research. 78:LB-254
Pancreatic ductal adenocarcinoma (PDAC) is a recalcitrant disease responsible for ~43,000 deaths in the USA in 2017. Despite an advanced understanding of the genetics, biochemistry and biology of pancreatic cancer, there is no effective pathway-targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1ceff86434b41a851eb5346a35b550a
https://doi.org/10.1158/1538-7445.am2018-lb-254
https://doi.org/10.1158/1538-7445.am2018-lb-254