Conformational buffering underlies functional selection in intrinsically disordered protein regions

Autor: Nicolás S. González-Foutel, Juliana Glavina, Wade M. Borcherds, Matías Safranchik, Susana Barrera-Vilarmau, Amin Sagar, Alejandro Estaña, Amelie Barozet, Nicolás A. Garrone, Gregorio Fernandez-Ballester, Clara Blanes-Mira, Ignacio E. Sánchez, Gonzalo de Prat-Gay, Juan Cortés, Pau Bernadó, Rohit V. Pappu, Alex S. Holehouse, Gary W. Daughdrill, Lucía B. Chemes

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Nat Struct Mol Biol
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, 2022, 29 (8), pp.781-790. ⟨10.1038/s41594-022-00811-w⟩

Many disordered proteins conserve essential functions in the face of extensive sequence variation, making it challenging to identify the mechanisms responsible for functional selection. Here we identify the molecular mechanism of functional selection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5686ad3777728c8721b6deba4c2af8
https://api.elsevier.com/content/abstract/scopus_id/85135867846

Characterization of plant microRNA-encoded peptides (miPEPs) reveals molecular mechanisms from the translation to activity and specificity

Autor: Dominique Lauressergues, Mélanie Ormancey, Bruno Guillotin, Hélène San Clemente, Laurent Camborde, Carine Duboé, Sabine Tourneur, Pierre Charpentier, Amélie Barozet, Alain Jauneau, Aurélie Le Ru, Patrice Thuleau, Virginie Gervais, Serge Plaza, Jean-Philippe Combier

Publikováno v: Cell Reports, Vol 38, Iss 6, Pp 110339- (2022)

Summary: MicroRNAs (miRNAs) are transcribed as long primary transcripts (pri-miRNAs) by RNA polymerase II. Plant pri-miRNAs encode regulatory peptides called miPEPs, which specifically enhance the transcription of the pri-miRNA from which they origin

Externí odkaz: https://doaj.org/article/1dccf78d2e134ef496ee61a04ffff6c4