Sirolimus Pharmacokinetics Variability Points to the Relevance of Therapeutic Drug Monitoring in Pediatric Oncology

Autor: Amelia-Naomi Sabo, Sarah Jannier, Guillaume Becker, Jean-Marc Lessinger, Natacha Entz-Werlé, Véronique Kemmel

Publikováno v: Pharmaceutics, Vol 13, Iss 4, p 470 (2021)

Sirolimus is widely used in transplantation, where its therapeutic drug monitoring (TDM) is well established. Evidence of a crucial role for sirolimus in the PI3K/AkT/mTor pathway has stimulated interest in its involvement in neoplasia, either as mon

Externí odkaz: https://doaj.org/article/00716eb37cd84a67bb3d5dc13b921cb5

Angiotensin-converting enzyme inhibitor induced angioedema: not always a class effect? A case report and short narrative review

Autor: Marie-Caroline Dalmas, Laurent Monassier, Estelle Ayme-Dietrich, Fabien Rougerie, Amelia-Naomi Sabo, Guillaume Becker

Publikováno v: Current Medical Research and Opinion
Current Medical Research and Opinion, Taylor & Francis, 2021, 37 (11), pp.1855-1858. ⟨10.1080/03007995.2021.1971183⟩

Bradykinin-mediated angioedema is a rare but potentially fatal adverse event. Angioedema induced by angiotensin-converting enzyme (ACE) inhibitors is generally attributed to an inhibition of bradykinin degradation following ACE inhibition. Clinical s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebff6c80195677a4fc3c0705e496f2fb
https://pubmed.ncbi.nlm.nih.gov/34412518

Blood–Brain Barrier Permeability: Is 5-Hydroxytryptamine Receptor Type 4 a Game Changer?

Autor: Sylvia Da Silva, Amelia-Naomi Sabo, Véronique Kemmel, Laurent Monassier, Maria Cristina Antal, Guillaume Becker

Publikováno v: Pharmaceutics, Vol 13, Iss 1856, p 1856 (2021)
Pharmaceutics
Pharmaceutics, 2021, 13 (11), pp.1856. ⟨10.3390/pharmaceutics13111856⟩
Volume 13
Issue 11

Serotonin affects many functions in the body, both in the central nervous system (CNS) and the periphery. However, its effect on the blood–brain barrier (BBB) in separating these two worlds has been scarcely investigated. The aim of this work was t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53df7ce3ea07b5b89634d54e07d7f3c0
https://doi.org/10.3390/pharmaceutics13111856

The 5-hydroxytryptamine receptor type 4 regulates blood-brain-barrier permeability

Autor: Laurent Monassier, Amelia-Naomi Sabo, Guillaume Becker, Véronique Kemmel, S. Da Silva

Publikováno v: Archives of Cardiovascular Diseases Supplements. 13:184

Introduction Serotonin (5-HT) plays a major role in cardiovascular regulations. The 5-HT4 Receptor (5-HT4R) elicits positive cardiac inotropic responses and contributes to atrial arrhythmias and ventricular hypertrophy. Nevertheless, headache is a co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0720b88e9eeeed71ffd6d64a24bccff
https://doi.org/10.1016/j.acvdsp.2021.04.093