Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain

Autor: Nelson Ferreira, Nádia Pereira Gonçalves, Asad Jan, Nanna Møller Jensen, Amelia van der Laan, Simin Mohseni, Christian Bjerggaard Vægter, Poul Henning Jensen

Publikováno v: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-17 (2021)

Abstract Pain is a common non-motor symptom of Parkinson’s disease (PD), with current limited knowledge of its pathophysiology. Here, we show that peripheral inoculation of mouse alpha-synuclein (α-Syn) pre-formed fibrils, in a transgenic mouse mo

Externí odkaz: https://doaj.org/article/80104fc9b45e4497b166570f57568963

Prodromal neuroinvasion of pathological α-synuclein in brainstem reticular nuclei and white matter lesions in a model of α-synucleinopathy

Autor: Glenda M. Halliday, Nelson Ferreira, Ida Bergholdt Jul Christiansen, Joachim Weiss, Mette Richner, Asad Jan, Ian R. A. Mackenzie, Jens R. Nyengaard, Christian Bjerggaard Vaegter, Amelia van der Laan, Benoit I. Giasson, Poul Henning Jensen

Publikováno v: Brain Communications
Ferreira, N, Richner, M, van der Laan, A, Bergholdt Jul Christiansen, I, Vægter, C B, Nyengaard, J R, Halliday, G M, Weiss, J, Giasson, B I, Mackenzie, I R, Jensen, P H & Jan, A 2021, ' Prodromal neuroinvasion of pathological α-synuclein in brainstem reticular nuclei and white matter lesions in a model of α-synucleinopathy ', Brain Communications, vol. 3, no. 2, fcab104 . https://doi.org/10.1093/braincomms/fcab104
Brain communications 3(2), fcab104 (2021). doi:10.1093/braincomms/fcab104

Neuropathological observations in neurodegenerative synucleinopathies, including Parkinson disease, implicate a pathological role of α-synuclein accumulation in extranigral sites during the prodromal phase of the disease. In a transgenic mouse model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b7249248bbeb2c6b89758fc758bf7b
https://pubmed.ncbi.nlm.nih.gov/35386219

α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response

Autor: Poul H. Sorensen, Christian Bjerggaard Vaegter, Poul Henning Jensen, Asad Jan, Amelia van der Laan, Ida Bergholdt Jul Christiansen, Jens R. Nyengaard, Alberto Delaidelli, Lixiang Jiang, Mette Richner, Nelson Ferreira, Ian R. Mackenzie

Publikováno v: Delaidelli, A, Richner, M, Jiang, L, van der Laan, A, Bergholdt Jul Christiansen, I, Ferreira, N, Nyengaard, J R, Vægter, C B, Jensen, P H, Mackenzie, I R, Sorensen, P H & Jan, A 2021, ' α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response ', Acta Neuropathologica Communications, vol. 9, no. 1, 105 . https://doi.org/10.1186/s40478-021-01209-3
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-16 (2021)

Circumstantial evidence points to a pathological role of alpha-synuclein (aSyn; gene symbol SNCA), conferred by aSyn misfolding and aggregation, in Parkinson disease (PD) and related synucleinopathies. Several findings in experimental models implicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870984427e56b06b8f0a9543f37a4443