Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Amelia W, Hall"'
Autor:
Shaan Khurshid, Julieta Lazarte, James P. Pirruccello, Lu-Chen Weng, Seung Hoan Choi, Amelia W. Hall, Xin Wang, Samuel F. Friedman, Victor Nauffal, Kiran J. Biddinger, Krishna G. Aragam, Puneet Batra, Jennifer E. Ho, Anthony A. Philippakis, Patrick T. Ellinor, Steven A. Lubitz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
A genome-wide association study of cardiac magnetic resonance-derived left ventricular mass index including 43,000 UK Biobank participants reveals 12 associations (11 novel), implicating genes involved in cardiac contractility and cardiomyopathy.
Externí odkaz:
https://doaj.org/article/1a8e275a72c04f6d9ede2ed763e2d9bc
Autor:
Jennifer L. Halford, Valerie N. Morrill, Seung Hoan Choi, Sean J. Jurgens, Giorgio Melloni, Nicholas A. Marston, Lu-Chen Weng, Victor Nauffal, Amelia W. Hall, Sophia Gunn, Christina A. Austin-Tse, James P. Pirruccello, Shaan Khurshid, Heidi L. Rehm, Emelia J. Benjamin, Eric Boerwinkle, Jennifer A. Brody, Adolfo Correa, Brandon K. Fornwalt, Namrata Gupta, Christopher M. Haggerty, Stephanie Harris, Susan R. Heckbert, Charles C. Hong, Charles Kooperberg, Henry J. Lin, Ruth J. F. Loos, Braxton D. Mitchell, Alanna C. Morrison, Wendy Post, Bruce M. Psaty, Susan Redline, Kenneth M. Rice, Stephen S. Rich, Jerome I. Rotter, Peter F. Schnatz, Elsayed Z. Soliman, Nona Sotoodehnia, Eugene K. Wong, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Marc S. Sabatine, Christian T. Ruff, Kathryn L. Lunetta, Patrick T. Ellinor, Steven A. Lubitz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Accurate classification of genetic variants is critical for research and patient care. Here, the authors report that population-based associations between rare variants and quantitative endophenotypes for monogenic diseases can provide support for va
Externí odkaz:
https://doaj.org/article/816988c3c3b240bbb3a8c919e46440d7
Autor:
Bridget Simonson, Mark Chaffin, Matthew C. Hill, Ondine Atwa, Yasmine Guedira, Harshit Bhasin, Amelia W. Hall, Sikander Hayat, Simon Baumgart, Kenneth C. Bedi, Jr., Kenneth B. Margulies, Carla A. Klattenhoff, Patrick T. Ellinor
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112086- (2023)
Summary: Ischemic cardiomyopathy (ICM) is the leading cause of heart failure worldwide, yet the cellular and molecular signature of this disease is largely unclear. Using single-nucleus RNA sequencing (snRNA-seq) and integrated computational analyses
Externí odkaz:
https://doaj.org/article/20970c7a3b5845f094b6b93928416d12
Autor:
Jennifer L. Halford, Valerie N. Morrill, Seung Hoan Choi, Sean J. Jurgens, Giorgio Melloni, Nicholas A. Marston, Lu-Chen Weng, Victor Nauffal, Amelia W. Hall, Sophia Gunn, Christina A. Austin-Tse, James P. Pirruccello, Shaan Khurshid, Heidi L. Rehm, Emelia J. Benjamin, Eric Boerwinkle, Jennifer A. Brody, Adolfo Correa, Brandon K. Fornwalt, Namrata Gupta, Christopher M. Haggerty, Stephanie Harris, Susan R. Heckbert, Charles C. Hong, Charles Kooperberg, Henry J. Lin, Ruth J. F. Loos, Braxton D. Mitchell, Alanna C. Morrison, Wendy Post, Bruce M. Psaty, Susan Redline, Kenneth M. Rice, Stephen S. Rich, Jerome I. Rotter, Peter F. Schnatz, Elsayed Z. Soliman, Nona Sotoodehnia, Eugene K. Wong, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Marc S. Sabatine, Christian T. Ruff, Kathryn L. Lunetta, Patrick T. Ellinor, Steven A. Lubitz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/001990be3a844416bee130cfd57f4151
Autor:
Victor, Nauffal, Valerie N, Morrill, Sean J, Jurgens, Seung Hoan, Choi, Amelia W, Hall, Lu-Chen, Weng, Jennifer L, Halford, Christina, Austin-Tse, Christopher M, Haggerty, Stephanie L, Harris, Eugene K, Wong, Alvaro, Alonso, Dan E, Arking, Emelia J, Benjamin, Eric, Boerwinkle, Yuan-I, Min, Adolfo, Correa, Brandon K, Fornwalt, Susan R, Heckbert, Charles, Kooperberg, Henry J, Lin, Ruth, J F Loos, Kenneth M, Rice, Namrata, Gupta, Thomas W, Blackwell, Braxton D, Mitchell, Alanna C, Morrison, Bruce M, Psaty, Wendy S, Post, Susan, Redline, Heidi L, Rehm, Stephen S, Rich, Jerome I, Rotter, Elsayed Z, Soliman, Nona, Sotoodehnia, Kathryn L, Lunetta, Patrick T, Ellinor, Steven A, Lubitz
Publikováno v:
Circulation
Circulation, 145(20), 1524-1533. Lippincott Williams and Wilkins
Circulation, 145(20), 1524-1533. Lippincott Williams and Wilkins
Background: Rare sequence variation in genes underlying cardiac repolarization and common polygenic variation influence QT interval duration. However, current clinical genetic testing of individuals with unexplained QT prolongation is restricted to e
Autor:
Sian O' Brien, Andrew P. Holmes, Daniel M. Johnson, S. Nashitha Kabir, Christopher O' Shea, Molly O' Reilly, Adelisa Avezzu, Jasmeet S. Reyat, Amelia W. Hall, Clara Apicella, Patrick T. Ellinor, Steven Niederer, Nathan R. Tucker, Larissa Fabritz, Paulus Kirchhof, Davor Pavlovic
Atrial fibrillation (AF) affects over 1% of the population and is a leading cause of stroke and heart failure in the elderly. A feared side effect of sodium channel blocker therapy, ventricular pro-arrhythmia, appears to be relatively rare in patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::978c50e204b5bb0d3afc935e4259b287
http://oro.open.ac.uk/81833/1/OBrien_et_al_Atrial_vs_Ventricular_Sodium_JMCC_13_01_2022.pdf
http://oro.open.ac.uk/81833/1/OBrien_et_al_Atrial_vs_Ventricular_Sodium_JMCC_13_01_2022.pdf
Autor:
Zachary A. Kadow, Nathan R. Tucker, Wouter de Laat, Antoinette F. van Ouwerkerk, Paulus Kirchhof, Valerio Bianchi, Fernanda M Bosada, Vincent M. Christoffels, James F. Martin, Rangarajan D. Nadadur, Larissa Fabritz, Jasmeet S. Reyat, Ivan P. Moskowitz, Amelia W. Hall, Sonja Lazarevic, Patrick T. Ellinor
Publikováno v:
Circulation research, 127(1), 34-50. Lippincott Williams and Wilkins
Genome-wide association studies have uncovered over a 100 genetic loci associated with atrial fibrillation (AF), the most common arrhythmia. Many of the top AF-associated loci harbor key cardiac transcription factors, including PITX2, TBX5, PRRX1, an
Autor:
Mark Chaffin, Sean J. Jurgens, Lu-Chen Weng, Steven A. Lubitz, Amit Khera, Seung Hoan Choi, Christina J.-Y. Lee, James P. Pirruccello, Kathryn L. Lunetta, Carolina Roselli, Amelia W. Hall, Patrick T. Ellinor
Publikováno v:
Circ Res
Rationale: Genome-wide association studies have identified over 100 genetic loci for atrial fibrillation (AF); recent work described an association between loss-of-function (LOF) variants in TTN and early-onset AF. Objective: We sought to determine t
Autor:
Michiel L. Bots, Annette Peters, Jennifer A. Brody, Pim van der Harst, Niek Verweij, Torben Hansen, Lu-Chen Weng, Marco V Perez, Honghuang Lin, Nona Sotoodehnia, Katharina Schramm, Dennis O. Mook-Kanamori, Marcus Dörr, Susan R. Heckbert, Henry J. Lin, Jie Yao, Paul L. Huang, Melanie Waldenberger, Bruno H. Stricker, Cornelia M. van Duijn, Jelena Kornej, Kent D. Taylor, Stephan B. Felix, Julia Ramirez, Xiuqing Guo, Peter van der Meer, Patrick T. Ellinor, Emelia J. Benjamin, Amelia W. Hall, Martina Müller-Nurasyid, Steven A. Lubitz, Alexander Teumer, Ilonca Vaartjes, Niels Grarup, Kathryn L. Lunetta, Marten E. van den Berg, Aaron Isaacs, Uwe Völker, Bruce M. Psaty, Jan A. Kors, Alvaro Alonso, Seung Hoan Choi, Rudolf A. de Boer, Allan Linneberg, Sandosh Padmanabhan, Helen R. Warren, Jerome I. Rotter, Nathan A. Bihlmeyer, Man Li, Jeffrey Haessler, Charles Kooperberg, Moritz F. Sinner, Sean J. Jurgens, Folkert W. Asselbergs, Dan E. Arking, Ruifang Li-Gao, Jessica van Setten, Patricia B. Munroe, Jørgen K. Kanters, Stefan Kääb
Publikováno v:
Circulation: Genomic and Precision Medicine
Circulation. Genomic and precision medicine, vol 13, iss 5
Circulation: Genomic and Precision Medicine, 13(5):002874, 387-395. Lippincott Williams and Wilkins Ltd.
Circ. Genom. Precis. Med. 13, 387-395 (2020)
Circulation: Genomic and Precision Medicine, 13(5), 387-395. LIPPINCOTT WILLIAMS & WILKINS
Circ Genom Precis Med
Circulation-Genomic and Precision Medicine, 13(5), 387-395. Lippincott Williams & Wilkins
Circulation. Genomic and precision medicine, 13(5), 387-395. Lippincott Williams and Wilkins Ltd.
Circulation. Genomic and precision medicine, vol 13, iss 5
Circulation: Genomic and Precision Medicine, 13(5):002874, 387-395. Lippincott Williams and Wilkins Ltd.
Circ. Genom. Precis. Med. 13, 387-395 (2020)
Circulation: Genomic and Precision Medicine, 13(5), 387-395. LIPPINCOTT WILLIAMS & WILKINS
Circ Genom Precis Med
Circulation-Genomic and Precision Medicine, 13(5), 387-395. Lippincott Williams & Wilkins
Circulation. Genomic and precision medicine, 13(5), 387-395. Lippincott Williams and Wilkins Ltd.
Background: The P-wave duration (PWD) is an electrocardiographic measurement that represents cardiac conduction in the atria. Shortened or prolonged PWD is associated with atrial fibrillation (AF). We used exome-chip data to examine the associations
Autor:
Na Li, Patrick T. Ellinor, Paul S. Swinton, John Leach, Nathan R. Tucker, Kenneth B. Margulies, James F. Martin, Matthew C. Hill, Ji Ho Suh, Tien T. Tran, Min Zhang, Amelia W. Hall, Zachary A. Kadow
Publikováno v:
Proceedings of the National Academy of Sciences. 116:22692-22698
Genome-wide association studies found that increased risk for atrial fibrillation (AF), the most common human heart arrhythmia, is associated with noncoding sequence variants located in proximity to PITX2 . Cardiomyocyte-specific epigenomic and compa