The Ultraviolet Irradiation of Keratinocytes Induces Ectopic Expression of LINE-1 Retrotransposon Machinery and Leads to Cellular Senescence

Autor: Fadi Touma, Marine Lambert, Amelia Martínez Villarreal, Jennifer Gantchev, Brandon Ramchatesingh, Ivan V. Litvinov

Publikováno v: Biomedicines, Vol 11, Iss 11, p 3017 (2023)

Retrotransposons have played an important role in evolution through their transposable activity. The largest and the only currently active human group of mobile DNAs are the LINE-1 retrotransposons. The ectopic expression of LINE-1 has been correlate

Externí odkaz: https://doaj.org/article/a566e2adac2f4caf826ba5d7aa87b4ed

Understanding Cell Lines, Patient-Derived Xenograft and Genetically Engineered Mouse Models Used to Study Cutaneous T-Cell Lymphoma

Autor: Raman Preet Kaur Gill, Jennifer Gantchev, Amelia Martínez Villarreal, Brandon Ramchatesingh, Elena Netchiporouk, Oleg E. Akilov, Niels Ødum, Robert Gniadecki, Sergei B. Koralov, Ivan V. Litvinov

Publikováno v: Cells, Vol 11, Iss 4, p 593 (2022)

Cutaneous T cell lymphoma (CTCL) is a spectrum of lymphoproliferative disorders caused by the infiltration of malignant T cells into the skin. The most common variants of CTCL include mycosis fungoides (MF), Sézary syndrome (SS) and CD30+ Lymphoprol

Externí odkaz: https://doaj.org/article/db3fc904cfe9480293ac250c190b122f

Ectopically Expressed Meiosis-Specific Cancer Testis Antigen HORMAD1 Promotes Genomic Instability in Squamous Cell Carcinomas

Autor: Litvinov, Jennifer Gantchev, Julia Messina-Pacheco, Amelia Martínez Villarreal, Brandon Ramchatesingh, Philippe Lefrançois, Pingxing Xie, Laetitia Amar, Hong Hao Xu, Keerthenan Raveendra, Daniel Sikorski, Daniel Josue Guerra Ordaz, Raman Preet Kaur Gill, Marine Lambert, Ivan V.

Publikováno v: Cells; Volume 12; Issue 12; Pages: 1627

Genomic instability is a prominent hallmark of cancer, however the mechanisms that drive and sustain this process remain elusive. Research demonstrates that numerous cancers with increased levels of genomic instability ectopically express meiosis-spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::688443ba17d64b54a37b4b4ceb2539c7

In silico analyses of the tumor microenvironment highlight tumoral inflammation, a Th2 cytokine shift and a mesenchymal stem cell-like phenotype in advanced in basal cell carcinomas

Autor: Ivan V. Litvinov, Scott Gunn, Philippe Lefrançois, Jennifer Gantchev, Denis Sasseville, Amelia Martínez Villarreal, Pingxing Xie

Publikováno v: J Cell Commun Signal

Basal Cell Carcinoma (BCC) represents the most common form of all cancers. BCC is characteristically surrounded by a fibromyxoid stroma. Previous studies have suggested a shift towards a Th2 response, an increase in T regulatory lymphocytes and the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b88b964cd3f9eba90fd497ceced5c6d
https://doi.org/10.1007/s12079-020-00563-6

Hypopigmented Mycosis Fungoides: Loss of Pigmentation Reflects Antitumor Immune Response in Young Patients

Autor: Amelia Martínez Villarreal, Denis Sasseville, Jennifer Gantchev, Niels Ødum, Yann Vincent Charli-Joseph, Augustin C. Barolet, Amparo Hernández Salazar, François Lagacé, Ivan V. Litvinov

Publikováno v: Cancers
Cancers, Vol 12, Iss 2007, p 2007 (2020)
Villarreal, A M, Gantchev, J, Lagacé, F, Barolet, A, Sasseville, D, Ødum, N, Charli-Joseph, Y V, Salazar, A H & Litvinov, I V 2020, ' Hypopigmented mycosis fungoides : Loss of pigmentation reflects antitumor immune response in young patients ', Cancers, vol. 12, no. 8, 2007, pp. 1-21 . https://doi.org/10.3390/cancers12082007

Hypopigmented mycosis fungoides (HMF) is a form of cutaneous T-cell lymphoma (CTCL), a heterogeneous group of extranodal non-Hodgkin’s lymphomas. HMF has a unique set of defining features that include light colored to achromic lesions, a predilecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42a34a0ef32b86a90341cee33132b95
https://pubmed.ncbi.nlm.nih.gov/32707930