Clinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortiumResearch in context

Autor: Francesca Sperotto, Alba Gutiérrez-Sacristán, Simran Makwana, Xiudi Li, Valerie N. Rofeberg, Tianxi Cai, Florence T. Bourgeois, Gilbert S. Omenn, David A. Hanauer, Carlos Sáez, Clara-Lea Bonzel, Emily Bucholz, Audrey Dionne, Matthew D. Elias, Noelia García-Barrio, Tomás González González, Richard W. Issitt, Kate F. Kernan, Jessica Laird-Gion, Sarah E. Maidlow, Kenneth D. Mandl, Taha Mohseni Ahooyi, Cinta Moraleda, Michele Morris, Karyn L. Moshal, Miguel Pedrera-Jiménez, Mohsin A. Shah, Andrew M. South, Anastasia Spiridou, Deanne M. Taylor, Guillaume Verdy, Shyam Visweswaran, Xuan Wang, Zongqi Xia, Joany M. Zachariasse, Jane W. Newburger, Paul Avillach, James R. Aaron, Atif Adam, Giuseppe Agapito, Adem Albayrak, Giuseppe Albi, Mario Alessiani, Anna Alloni, Danilo F. Amendola, François Angoulvant, Li LLJ. Anthony, Bruce J. Aronow, Fatima Ashraf, Andrew Atz, Vidul Ayakulangara Panickan, Paula S. Azevedo, Rafael Badenes, James Balshi, Ashley Batugo, Brendin R. Beaulieu-Jones, Brett K. Beaulieu-Jones, Douglas S. Bell, Antonio Bellasi, Riccardo Bellazzi, Vincent Benoit, Michele Beraghi, José Luis Bernal-Sobrino, Mélodie Bernaux, Romain Bey, Surbhi Bhatnagar, Alvar Blanco-Martínez, Martin Boeker, John Booth, Silvano Bosari, Robert L. Bradford, Gabriel A. Brat, Stéphane Bréant, Nicholas W. Brown, Raffaele Bruno, William A. Bryant, Mauro Bucalo, Anita Burgun, Mario Cannataro, Aldo Carmona, Anna Maria Cattelan, Charlotte Caucheteux, Julien Champ, Jin Chen, Krista Y. Chen, Luca Chiovato, Lorenzo Chiudinelli, Kelly Cho, James J. Cimino, Tiago K. Colicchio, Sylvie Cormont, Sébastien Cossin, Jean B. Craig, Juan Luis Cruz-Bermúdez, Jaime Cruz-Rojo, Arianna Dagliati, Mohamad Daniar, Christel Daniel, Priyam Das, Batsal Devkota, Rui Duan, Julien Dubiel, Scott L. DuVall, Loic Esteve, Hossein Estiri, Shirley Fan, Robert W. Follett, Thomas Ganslandt, Lana X. Garmire, Nils Gehlenborg, Emily J. Getzen, Alon Geva, Rachel SJ. Goh, Tobias Gradinger, Alexandre Gramfort, Romain Griffier, Nicolas Griffon, Olivier Grisel, Pietro H. Guzzi, Larry Han, Christian Haverkamp, Derek Y. Hazard, Bing He, Darren W. Henderson, Martin Hilka, Yuk-Lam Ho, John H. Holmes, Jacqueline P. Honerlaw, Chuan Hong, Kenneth M. Huling, Meghan R. Hutch, Anne Sophie Jannot, Vianney Jouhet, Mundeep K. Kainth, Kernan F. Kate, Ramakanth Kavuluru, Mark S. Keller, Chris J. Kennedy, Daniel A. Key, Katie Kirchoff, Jeffrey G. Klann, Isaac S. Kohane, Ian D. Krantz, Detlef Kraska, Ashok K. Krishnamurthy, Sehi L'Yi, Judith Leblanc, Guillaume Lemaitre, Leslie Lenert, Damien Leprovost, Molei Liu, Ne Hooi Will Loh, Qi Long, Sara Lozano-Zahonero, Yuan Luo, Kristine E. Lynch, Sadiqa Mahmood, Adeline Makoudjou, Alberto Malovini, Chengsheng Mao, Anupama Maram, Monika Maripuri, Patricia Martel, Marcelo R. Martins, Jayson S. Marwaha, Aaron J. Masino, Maria Mazzitelli, Diego R. Mazzotti, Arthur Mensch, Marianna Milano, Marcos F. Minicucci, Bertrand Moal, Jason H. Moore, Jeffrey S. Morris, Sajad Mousavi, Danielle L. Mowery, Douglas A. Murad, Shawn N. Murphy, Thomas P. Naughton, Carlos Tadeu Breda Neto, Antoine Neuraz, Jane Newburger, Kee Yuan Ngiam, Wanjiku FM. Njoroge, James B. Norman, Jihad Obeid, Marina P. Okoshi, Karen L. Olson, Nina Orlova, Brian D. Ostasiewski, Nathan P. Palmer, Nicolas Paris, Lav P. Patel, Ashley C. Pfaff, Emily R. Pfaff, Danielle Pillion, Sara Pizzimenti, Tanu Priya, Hans U. Prokosch, Robson A. Prudente, Andrea Prunotto, Víctor Quirós-González, Rachel B. Ramoni, Maryna Raskin, Siegbert Rieg, Gustavo Roig-Domínguez, Pablo Rojo, Nekane Romero-Garcia, Paula Rubio-Mayo, Paolo Sacchi, Elisa Salamanca, Malarkodi Jebathilagam Samayamuthu, L. Nelson Sanchez-Pinto, Arnaud Sandrin, Nandhini Santhanam, Janaina C.C. Santos, Fernando J. Sanz Vidorreta, Maria Savino, Emily R. Schriver, Petra Schubert, Juergen Schuettler, Luigia Scudeller, Neil J. Sebire, Pablo Serrano-Balazote, Patricia Serre, Arnaud Serret-Larmande, Zahra Shakeri Hossein Abad, Domenick Silvio, Piotr Sliz, Jiyeon Son, Charles Sonday, Zachary H. Strasser, Amelia LM. Tan, Bryce W.Q. Tan, Byorn W.L. Tan, Suzana E. Tanni, Ana I. Terriza-Torres, Valentina Tibollo, Patric Tippmann, Emma MS. Toh, Carlo Torti, Enrico M. Trecarichi, Andrew K. Vallejos, Gael Varoquaux, Margaret E. Vella, Jill-Jênn Vie, Michele Vitacca, Kavishwar B. Wagholikar, Lemuel R. Waitman, Demian Wassermann, Griffin M. Weber, Martin Wolkewitz, Scott Wong, Xin Xiong, Ye Ye, Nadir Yehya, William Yuan, Janet J. Zahner, Alberto Zambelli, Harrison G. Zhang, Daniela Zöller, Valentina Zuccaro, Chiara Zucco

Publikováno v: EClinicalMedicine, Vol 64, Iss , Pp 102212- (2023)

Summary: Background: Multisystem inflammatory syndrome in children (MIS-C) is a severe complication of SARS-CoV-2 infection. It remains unclear how MIS-C phenotypes vary across SARS-CoV-2 variants. We aimed to investigate clinical characteristics and

Externí odkaz: https://doaj.org/article/8cb0959ec9ce4e99b1619c8db011de4a

Neurological Diagnoses in Hospitalized COVID-19 Patients Associated With Adverse Outcomes: A Multinational Cohort Study

Autor: Meghan R. Hutch, Jiyeon Son, Trang T. Le, Chuan Hong, Xuan Wang, Zahra Shakeri Hossein Abad, Michele Morris, Alba Gutiérrez-Sacristán, Jeffrey G. Klann, Anastasia Spiridou, Riccardo Bellazzi, Vincent Benoit, Clara-Lea Bonzel, William A. Bryant, Kelly Cho, Priyam Das, David A. Hanauer, Darren W. Henderson, Yuk-Lam Ho, Ne Hooi Will Loh, Adeline Makoudjou, Alberto Malovini, Bertrand Moal, Danielle L. Mowery, Malarkodi Jebathilagam Samayamuthu, Fernando J. Sanz Vidorreta, Emily R. Schriver, Petra Schubert, Jeffrey Talbert, Amelia LM Tan, Byorn WL Tan, Bryce WQ Tan, Valentina Tibollo, William Yuan, Paul Avillach, Nils Gehlenborg, Gilbert S. Omenn, Shyam Visweswaran, Tianxi Cai, Yuan Luo, Zongqi Xia

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec584ab099f751200b5b26fbffc57877
https://doi.org/10.2139/ssrn.4057133

Multinational Prevalence of Neurological Phenotypes in Patients Hospitalized with COVID-19

Autor: Kee Yuan Ngiam, Michele I. Morris, Lav P Patel, Chuan Hong, Andrew M South, Trang T. Le, Emily Schriver, Jiyeon Son, Yuan Luo, Jason H. Moore, Zongqi Xia, Paul Avillach, Brett K Beaulieu-Jones, Shyam Visweswaran, Malarkodi J Samayamuthu, Tianxi Cai, Isaac S. Kohane, Amelia Lm Tan, Ne Hooi Will Loh, Gilbert S. Omenn, Danielle L. Mowery, Alba Gutiérrez-Sacristán

Publikováno v: medRxiv

OBJECTIVENeurological complications can worsen outcomes in COVID-19. We defined the prevalence of a wide range of neurological conditions among patients hospitalized with COVID-19 in geographically diverse multinational populations.METHODSUsing elect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62608efedf8231a303035c0f9a0c4fe
https://doi.org/10.1101/2021.01.27.21249817

International Electronic Health Record-Derived COVID-19 Clinical Course Profiles: The 4CE Consortium

Autor: Patricia Martel, Alberto Zambelli, Nina Orlova, Vincent Benoit, Lemuel R. Waitman, Hans U. Prokosch, Nicolas Paris, Danielle L. Mowery, Lav P Patel, Nathan Palmer, Martin Hilka, Douglas A. Murad, Julien Dubiel, Jill Jen Vie, Batsal Devkota, Gabriel A. Brat, Kee Yuan Ngiam, Jason H. Moore, Robert L. Bradford, Stephane Breant, Douglas S. Bell, Thomas Ganslandt, Anne-Sophie Jannot, Martin Boeker, Amelia Lm Tan, Brett K. Beaulieu-Jones, Riccardo Bellazzi, Katie Kirchoff, Robert W Follett, Shawn N. Murphy, Judith Leblanc, Jihad S. Obeid, Tobias Gradinger, Antonio Bellasi, Nils Gehlenborg, Arnaud Sandrin, Patricia Serre, Romain Bey, Arthur Mensch, Universities, Nicolas Griffon, Valentina Tibollo, Romain Griffier, Alba Gutiérrez-Sacristán, Mélodie Bernaux, Sehi L'Yi, Vianney Jouhet, Julien Champ, Mohamad Daniar, Christel Daniel, David A. Hanauer, Thomas Moreau, John J. Holmes, Piotr Sliz, Luca Chiovato, Mauro Bucalo, Elisa Salamanca, Damien Leprovost, Christian Haverkamp, Olivier Grisel, Luigia Scudeller, Isaac S. Kohane, Jean Craig, Arnaud Serret-Larmande, Alexandre Gramfort, Alberto Malovini, Griffin M. Weber, Bertrand Moal, Charlotte Caucheteux, Mark Keller, Guillaume Lemaitre, Paul Avillach, Ap-Hp, Kenneth D. Mandl, Jeffrey G. Klann, Demian Wassermann, Sébastien Cossin, James J. Cimino, Detlef Kraska, Gaël Varoquaux, Anita Burgun, Gilbert S. Omenn, Emily Schiver, Tianxi Cai

We leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) of 96 hospitals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90c519bd4c59332b207f86abf4b408c