Výsledky vyhledávání - "Amelia K. Scaffidi"

Assessment of p.Phe508del-CFTR functional restoration in pediatric primary cystic fibrosis airway epithelial cells

Autor: Amelia K. Scaffidi, David F. Fischer, Kevin Looi, Stephen M. Stick, Clara J. Foo, Luke W. Garratt, Erika N. Sutanto, Michela Tessari, Richard A.J. Janssen, Anthony Kicic

Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0191618 (2018)
PLoS ONE

Background Mutations in the cystic fibrosis transmembrane regulator (CFTR) gene can reduce function of the CFTR ion channel activity and impair cellular chloride secretion. The gold standard method to assess CFTR function of ion transport using the U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d947b6be161ee07990c5ad4bc8339b9e
http://europepmc.org/articles/PMC5779693?pdf=render

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A positive postdoctoral experience is related to quality supervision and career mentoring, collaborations, networking and a nurturing research environment

Autor: Amelia K. Scaffidi, Judith E. Berman

Publikováno v: Higher Education. 62:685-698

For postdocs to have the best chances of achieving their career goals they need to not only acquire discipline-specific research experience, but also additional generic skills vital for future employment inside or outside academia. They also require

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d818df48ba52c6494793f3972c46c624
https://doi.org/10.1007/s10734-011-9407-1

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Comparison of the morphological and biochemical changes in normal human lung fibroblasts and fibroblasts derived from lungs of patients with idiopathic pulmonary fibrosis during FasL-induced apoptosis

Autor: Philip J. Thompson, Amelia K. Scaffidi, Robin J. McAnulty, John M. Papadimitriou, Yuben Moodley, Darryl A. Knight, Paul Caterina, Geoffrey J. Laurent, Neil L. A. Misso

Publikováno v: The Journal of Pathology. 202:486-495

It is increasingly recognized that the morphological changes of apoptosis vary between cell types. This heterogeneity reflects the wide range of cellular proteins and enzymes involved in apoptotic pathways. Fibroblast apoptosis is crucial to the regr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2041e958f5b655d0d22658bb6d17dd
https://doi.org/10.1002/path.1531

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Inverse Effects of Interleukin-6 on Apoptosis of Fibroblasts from Pulmonary Fibrosis and Normal Lungs

Autor: Mirjana Fogel-Petrovic, Yuben Moodley, Geoffrey J. Laurent, Amelia K. Scaffidi, Darryl A. Knight, Philip J. Thompson, Neil L. A. Misso, Robin J. McAnulty

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 29:490-498

Fibroblast apoptosis is crucial to the resolution of fibrosis. However, the mechanisms by which these cells undergo apoptosis are not well known. Because interleukin (IL)-6 and IL-11 may alter repair and remodeling processes, we hypothesized that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c61a3a02123b55c68af97c66b468565
https://doi.org/10.1165/rcmb.2002-0262oc

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Macrophage Recognition and Phagocytosis of Apoptotic Fibroblasts Is Critically Dependent on Fibroblast-Derived Thrombospondin 1 and CD36

Autor: Stuart Bunt, Philip J. Thompson, Neil L. A. Misso, Darryl A. Knight, Hideyuki Hayashi, Yuben Moodley, Paul Rigby, Amelia K. Scaffidi, Chris Bundell, Robin J. McAnulty, Geoffrey J. Laurent

Publikováno v: The American Journal of Pathology. 162:771-779

The induction of fibroblast apoptosis and their clearance by phagocytes is essential for normal wound healing and prevention of scarring. However, little is known about the clearance of apoptotic fibroblasts and whether apoptotic cells are active par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20dfd1777db9f5fca2d332ec8ad806fc
https://doi.org/10.1016/s0002-9440(10)63874-6

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Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts

Autor: Steven E. Mutsaers, Philip J. Thompson, Geoffrey J. Laurent, Darryl A. Knight, Amelia K. Scaffidi, Robin J. McAnulty, Yuben Moodley

Publikováno v: British Journal of Pharmacology. 136:793-801

Oncostatin M (OSM), a member of the interleukin-6 (IL-6) cytokine family, acts on a variety of cells and elicits diversified biological responses, suggesting potential roles in the regulation of cell survival, differentiation and proliferation. We ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97987a748829fe1b5a8b2e7388146ca8
https://doi.org/10.1038/sj.bjp.0704769

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Myotube Formation is Delayed but not Prevented in MyoD-deficient Skeletal Muscle: Studies in Regenerating Whole Muscle Grafts of Adult Mice

Autor: Miranda D. Grounds, Amelia K. Scaffidi, Marilyn Davies, John Mcgeachie, Jason D. White, Michael A. Rudnicki

Publikováno v: Journal of Histochemistry & Cytochemistry. 48:1531-1543

We compared the time course of myogenic events in vivo in regenerating whole muscle grafts in MyoD(−/−) and control BALB/c adult mice using immunohistochemistry and electron microscopy. Immunohistochemistry with antibodies to desmin and myosin re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d061d1e8315b913f195a2615e930bc
https://doi.org/10.1177/002215540004801110

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alpha(v)beta(3) Integrin interacts with the transforming growth factor beta (TGFbeta) type II receptor to potentiate the proliferative effects of TGFbeta1 in living human lung fibroblasts

Autor: Nenad Petrovic, Yuben Moodley, Karen M. Kroeger, Ruth M. Seeber, Amelia K. Scaffidi, Mirjana Fogel-Petrovic, Philip J. Thompson, Darryl A. Knight, Karin A. Eidne

Publikováno v: The Journal of biological chemistry. 279(36)

The alpha(v)beta(3) integrin is known to cooperate with receptor tyrosine kinases to enhance cellular responses. To determine whether alpha(v)beta(3) regulates transforming growth factor beta (TGFbeta) 1-induced responses, we investigated the interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d171ee49dd58714bed848a70f330eda5
https://pubmed.ncbi.nlm.nih.gov/15187087

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Fibroblasts Isolated from Normal Lungs and Those with Idiopathic Pulmonary Fibrosis Differ in Interleukin-6/gp130-Mediated Cell Signaling and Proliferation

Autor: Amelia K. Scaffidi, Steven E. Mutsaers, GJ Laurent, Neil L. A. Misso, Robin J. McAnulty, Darryl A. Knight, Yuben Moodley, Carmel B. Keerthisingam, Philip J. Thompson

Interleukin (IL)-6 and IL-11 are elevated in a variety of lung conditions and may impact on repair mechanisms in chronic inflammatory disorders. However, the mechanisms by which these cytokines influence fibroblast proliferation in normal and disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2768c126097950880842a07f33497ea1
https://europepmc.org/articles/PMC1868172/

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