Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Amelia J. Tomkins"'
Autor:
Tianwen Gao, Syed Ali Raza, Supriya Ramesha, Ngozi V. Nwabueze, Amelia J. Tomkins, Lihong Cheng, Hailian Xiao, Manuel Yepes, Srikant Rangaraju
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-11 (2019)
Abstract Background Microglia and CNS-infiltrating monocytes/macrophages (CNS-MPs) perform pro-inflammatory and protective anti-inflammatory functions following ischemic stroke. Selective inhibition of pro-inflammatory responses can be achieved by Kv
Externí odkaz:
https://doaj.org/article/1e7c74655e0240a7b3d0ea507bb54c77
Autor:
Amelia J. Tomkins, Rebecca J. Hood, Debbie Pepperall, Christopher L. Null, Christopher R. Levi, Neil J. Spratt
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 2 (2016)
BackgroundStroke associated with acute carotid occlusion is associated with poor effectiveness of tissue plasminogen activator (tPA) thrombolysis and poor prognosis. Rupture of atherosclerotic plaques resulting in vascular occlusions may occur on pla
Externí odkaz:
https://doaj.org/article/753ef988cdc547bd8f56de835f66c8c6
Autor:
Jessica A. A. Maclean, Amelia J. Tomkins, Sharelle A. Sturgeon, Benjamin R. Hofma, Imala Alwis, Andre L. Samson, Simone M. Schoenwaelder, Shaun P. Jackson
Publikováno v:
Blood advances. 6(18)
Recanalization with restored cerebral perfusion is the primary goal of thrombolytic therapy in acute ischemic stroke. The identification of adjunctive therapies that can be safely used to enhance thrombolysis in stroke remains an elusive goal. We rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323bba5fdc4b6f46abefe292a345c665
https://pubmed.ncbi.nlm.nih.gov/35767737
https://pubmed.ncbi.nlm.nih.gov/35767737
Autor:
Enrique Torre, Laura G Quiceno, Ariel Diaz, Manuel A. Yepes, Frank C. Tong, Chadwick M. Hales, Xiaodong Zhang, Amelia J. Tomkins, Manuel Yepes, Patrick McCann, Paola Merino
Publikováno v:
J Cereb Blood Flow Metab
Urokinase-type plasminogen activator (uPA) is a serine proteinase that catalyzes the generation of plasmin on the cell surface and activates cell signaling pathways that promote remodeling and repair. Neuronal cadherin (NCAD) is a transmembrane prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e2cba6f57c5a0c0c36fcd4722d4896
https://europepmc.org/articles/PMC8393294/
https://europepmc.org/articles/PMC8393294/
Autor:
Ngozi V. Nwabueze, Amelia J. Tomkins, Manuel Yepes, Hailian Xiao, Lihong Cheng, Syed Ali Raza, Tianwen Gao, Srikant Rangaraju, Supriya Ramesha
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-11 (2019)
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-11 (2019)
Background Microglia and CNS-infiltrating monocytes/macrophages (CNS-MPs) perform pro-inflammatory and protective anti-inflammatory functions following ischemic stroke. Selective inhibition of pro-inflammatory responses can be achieved by Kv1.3 chann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2fdc039a9d5cea3a1293707f5f5c1a
https://doi.org/10.1186/s12974-019-1510-8
https://doi.org/10.1186/s12974-019-1510-8
Autor:
Damian D. McLeod, I. Mhairi Macrae, Neil J. Spratt, William M. Holmes, Daniel J. Beard, Lucy A. Murtha, Sarah K. McCann, Amelia J. Tomkins, Debbie Pepperall, Christopher McCabe
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 35:592-600
In both the human and animal literature, it has largely been assumed that edema is the primary cause of intracranial pressure (ICP) elevation after stroke and that more edema equates to higher ICP. We recently demonstrated a dramatic ICP elevation 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35e6de1ddbae97a7f172c4dafd43ef4
https://doi.org/10.1038/jcbfm.2014.230
https://doi.org/10.1038/jcbfm.2014.230
Autor:
Rebecca J. Hood, Christopher L. Null, Amelia J. Tomkins, Christopher R Levi, Neil J. Spratt, Debbie Pepperall
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Stroke associated with acute carotid occlusion is associated with poor effectiveness of tissue plasminogen activator ( tPA ) thrombolysis and poor prognosis. Rupture of atherosclerotic plaques resulting in vascular occlusions may occur on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a6eb33f8c0caddc8fc4014f43fefc5
https://doi.org/10.1161/jaha.115.002716
https://doi.org/10.1161/jaha.115.002716
Autor:
Marian Kampschulte, Martin Juenemann, Mesut Yeniguen, Manfred Kaps, Neil J. Spratt, Amelia J. Tomkins, Catherine Botteron, Max Nedelmann, Gabriele A. Krombach, Nadine Schleicher, Tibo Gerriets, Jean-Marc Hyvelin
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152898 (2016)
PLoS ONE
PLoS ONE
Background Early recanalization of large cerebral vessels in ischemic stroke is associated with improved clinical outcome, however persisting hypoperfusion leads to poor clinical recovery despite large vessel recanalization. Limited experimental sono
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c41b15247a05d373d73123ac60d542c
http://europepmc.org/articles/PMC4831751?pdf=render
http://europepmc.org/articles/PMC4831751?pdf=render
Publikováno v:
Scientific Reports
Tissue plasminogen activator (tPA) is the only approved thrombolytic therapy for acute ischemic stroke, yet many patients do not recanalize. Enhancing thrombolytic efficacy of tPA is a major focus of stroke research. Traditionally, a “rat dose” o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1404fe3ab7ca18c3db265d105c0f01
https://doi.org/10.1038/srep16026
https://doi.org/10.1038/srep16026
Autor:
Amelia J, Tomkins, Nadine, Schleicher, Lucy, Murtha, Manfred, Kaps, Christopher R, Levi, Max, Nedelmann, Neil J, Spratt
Publikováno v:
Experimental & Translational Stroke Medicine
Background Early recanalization of occluded vessels in stroke is closely associated with improved clinical outcome. Microbubble-enhanced sonothrombolysis is a promising therapy to improve recanalization rates and reduce the time to recanalization. Te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::061f6a89e804fb0771e9989c1f819943
https://pubmed.ncbi.nlm.nih.gov/25657829
https://pubmed.ncbi.nlm.nih.gov/25657829