Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Amelia J. Brennan"'
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
When killing through the granule exocytosis pathway, cytotoxic lymphocytes release key effector molecules into the immune synapse, perforin and granzymes, to initiate target cell killing. The pore-forming perforin is essential for the function of cyt
Externí odkaz:
https://doaj.org/article/72534967b2074930a658cb5e8e398437
Autor:
Emily J. Lelliott, Kelly M. Ramsbottom, Mark R. Dowling, Carolyn Shembrey, Tahereh Noori, Conor J. Kearney, Jessica Michie, Ian A. Parish, Margaret A. Jordan, Alan G. Baxter, Neil D. Young, Amelia J. Brennan, Jane Oliaro
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cytotoxic lymphocytes are essential for anti-tumor immunity, and for effective responses to cancer immunotherapy. Natural killer cell granule protein 7 (NKG7) is expressed at high levels in cytotoxic lymphocytes infiltrating tumors from patients trea
Externí odkaz:
https://doaj.org/article/c8e517cb608a45a58a1cfaec14b8b317
Severely impaired CTL killing is a feature of the neurological disorder Niemann-Pick disease type C1
Autor:
Daniela Castiblanco, Jesse A. Rudd-Schmidt, Tahereh Noori, Vivien R. Sutton, Ya Hui Hung, Thijs W. H. Flinsenberg, Adrian W. Hodel, Neil D. Young, Nicholas Smith, Drago Bratkovic, Heidi Peters, Mark Walterfang, Joseph A. Trapani, Amelia J. Brennan, Ilia Voskoboinik
Publikováno v:
Blood. 139:1833-1849
Niemann-Pick disease type C1 (NP-C1) is a rare lysosomal storage disorder resulting from mutations in an endolysosomal cholesterol transporter, NPC1. Despite typically presenting with pronounced neurological manifestations, NP-C1 also resembles long-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8076d8b71ec0bd955f1f4011ff0b06e0
https://doi.org/10.1182/blood.2021013477
https://doi.org/10.1182/blood.2021013477
Autor:
Joseph A. Trapani, Michelle A. Dunstone, James C. Whisstock, S.C. Kondos, Sharon Tran, Ilia Voskoboinik, Helen R. Saibil, Bart W. Hoogenboom, Carl Leung, Natalya Lukoyanova, Amelia J. Brennan, Colin M. House, Adrian W. Hodel
Publikováno v:
Nature Nanotechnology. 12:467-473
Perforin is a key protein of the vertebrate immune system. Secreted by cytotoxic lymphocytes as soluble monomers, perforin can self-assemble into oligomeric pores of 10-20 nm inner diameter in the membranes of virus-infected and cancerous cells. Thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e43e88f9747ee5866e2fac702391a4
https://doi.org/10.1038/nnano.2016.303
https://doi.org/10.1038/nnano.2016.303
Autor:
Sarah Ellis, Ricky W. Johnstone, Kevin Y. T. Thia, Daniel M. Andrews, Ilia Voskoboinik, Amelia J. Brennan, Vivien R. Sutton, Gunnar Pejler, Joseph A. Trapani, Jill Danne, Misty R. Jenkins
Publikováno v:
FEBS Journal. 283:947-961
The anionic proteoglycan serglycin is a major constituent of secretory granules in cytotoxic T lymphocyte (CTL)/natural killer (NK) cells, and is proposed to promote the safe storage of the mostly cationic granule toxins, granzymes and perforin. Desp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b99e327ec49831df870e12137df2b39
https://doi.org/10.1111/febs.13649
https://doi.org/10.1111/febs.13649
Autor:
Annette Ciccone, Natalya Lukoyanova, Joseph A. Trapani, Helen R. Saibil, Sandra Verschoor, Ruby H. P. Law, James C. Whisstock, Tahereh Noori, Paul J. Conroy, Ilia Voskoboinik, Hideo Yagita, Amelia J. Brennan
The pore forming, Ca(2+)-dependent protein, perforin, is essential for the function of cytotoxic lymphocytes, which are at the frontline of immune defence against pathogens and cancer. Perforin is a glycoprotein stored in the secretory granules prior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26db7a8850e3b83c7b50a812bab8a6b
https://europepmc.org/articles/PMC6113324/
https://europepmc.org/articles/PMC6113324/
Autor:
Wenbo Yu, Danushka K. Wijesundara, Ilia Voskoboinik, Jason Gummow, Branka Grubor-Bauk, Amelia J. Brennan, Eric J. Gowans, Tamsin J. Garrod
Publikováno v:
Gene Therapy. 23:26-37
Currently, no vaccine is available against hepatitis C virus (HCV), and although DNA vaccines have considerable potential, this has not been realised. Previously, the efficacy of DNA vaccines for human immunodeficiency virus (HIV) and HCV was shown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ed533171ece5463ad4d5be781f6f87
https://doi.org/10.1038/gt.2015.86
https://doi.org/10.1038/gt.2015.86
Autor:
Alexander Dobrovic, Richard Saffery, Zac Chatterton, Ilia Voskoboinik, Kevin Y. T. Thia, Wei Z Yeh, Imran G House, Joseph A. Trapani, Amelia J. Brennan, Richard W. Tothill
Publikováno v:
Immunology & Cell Biology. 93:575-580
The production and delivery of functional perforin (PRF; PRF1 gene) by cytotoxic lymphocytes maintains immune homeostasis and tumour immune surveillance. In humans, inheritance of the common PRF1 polymorphism, p.A91V, (c.272C>T) found in 8-9% of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d0f316b8401855c991aa39b5e737c4
https://doi.org/10.1038/icb.2015.1
https://doi.org/10.1038/icb.2015.1
Autor:
Amelia J. Brennan, Ilia Voskoboinik, Joseph A. Trapani, Jane Oliaro, Imran G House, Kelly M Ramsbottom, Magdalena Hagn, Hideo Yagita
Publikováno v:
The Journal of Immunology. 193:5744-5750
Cytotoxic lymphocytes destroy pathogen-infected and transformed cells through the cytotoxic granule exocytosis death pathway, which is dependent on the delivery of proapoptotic granzymes into the target cell cytosol by the pore-forming protein, perfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1399572922379c2fa5efc04e98e6ffa
https://doi.org/10.4049/jimmunol.1402207
https://doi.org/10.4049/jimmunol.1402207
Autor:
Raymond S. Norton, Eleanor W. W. Leung, Annette Ciccone, Matthew A. Perugini, Natalya Lukoyanova, Hideo Yagita, Gordon J. Lloyd, Jamie A. Lopez, Joseph A. Trapani, Daouda A K Traore, James C. Whisstock, Sandra Verschoor, Kylie A. Browne, Con Dogovski, Ruby H. P. Law, Ilia Voskoboinik, Amelia J. Brennan
Publikováno v:
Biochemical Journal. 456:323-335
Following its secretion from cytotoxic lymphocytes into the immune synapse, perforin binds to target cell membranes through its Ca2+-dependent C2 domain. Membrane-bound perforin then forms pores that allow passage of pro-apoptopic granzymes into the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f12e10f14c4dfc3ab10d10236e630d8
https://doi.org/10.1042/bj20130999
https://doi.org/10.1042/bj20130999