Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Amelia J Lawler"'
Autor:
Robert L. Marshall, Georgina S. Lloyd, Amelia J. Lawler, Sarah J. Element, Jaswant Kaur, Maria Laura Ciusa, Vito Ricci, Andreas Tschumi, Holger Kühne, Luke J. Alderwick, Laura J. V. Piddock
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT Active efflux of antibiotics preventing their accumulation to toxic intracellular concentrations contributes to clinically relevant multidrug resistance. Inhibition of active efflux potentiates antibiotic activity, indicating that efflux inh
Externí odkaz:
https://doaj.org/article/2629c888b070459bbab02735e914fc43
Autor:
Jessica M A Blair, Pauline Siasat, Helen E McNeil, Abigail Colclough, Vito Ricci, Amelia J Lawler, Hind Abdalaal, Michelle M C Buckner, Alison Baylay, Stephen J Busby, Laura J V Piddock
Publikováno v:
Journal of Antimicrobial Chemotherapy. 78:133-140
Background Resistance nodulation division (RND) family efflux pumps, including the major pump AcrAB-TolC, are important mediators of intrinsic and evolved antibiotic resistance. Expression of these pumps is carefully controlled by a network of regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce04006e015dbfb490690a84adf4018b
https://doi.org/10.1093/jac/dkac364
https://doi.org/10.1093/jac/dkac364
Publikováno v:
Trends in Microbiology. 28:744-752
The dormant resistant spores of Clostridioides difficile are transformed into metabolically active cells through the process of germination. Spore germination in C. difficile is regulated by the detection of bile salt germinants and amino acid cogerm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfec8a742987e76562753a7403741943
https://doi.org/10.1016/j.tim.2020.03.004
https://doi.org/10.1016/j.tim.2020.03.004
Autor:
Vito Ricci, Georgina S. Lloyd, Maria Laura Ciusa, Andreas Tschumi, Jaswant Kaur, Sarah J Element, Amelia J. Lawler, Robert L Marshall, Luke J. Alderwick, Holger Kühne, Laura J. V. Piddock
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
mBio
mBio
Multidrug-resistant Gram-negative bacteria pose a serious threat to human and animal health. Molecules that inhibit multidrug efflux offer an alternative approach to resolving the challenges caused by antibiotic resistance, by potentiating the activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9faec9d216dc468a70d9309eb1c7e5b
https://journals.asm.org/doi/10.1128/mBio.01340-20
https://journals.asm.org/doi/10.1128/mBio.01340-20
Autor:
Louisa J. Thompson, Amelia J. Lawler, Vito Ricci, Jessica M A Blair, Laura J. V. Piddock, Helen Smith
Publikováno v:
Journal of Antimicrobial Chemotherapy
Objectives: Enterobacteriaceae have multiple efflux pumps that confer intrinsic resistance to antibiotics. AcrB mediates clinically relevant multidrug resistance and is required for virulence and biofilm formation, making it an attractive target for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449aa415b1f4ef2f20298cdc248fb597
https://doi.org/10.1093/jac/dku380
https://doi.org/10.1093/jac/dku380
Publikováno v:
Journal of Antimicrobial Chemotherapy
Received 14 November 2012; returned 14 January 2013; revised 23 January 2013; accepted 30 January 2013Objectives: The transcriptional activator RamA regulates production of the multidrug resistance efflux AcrAB–TolC system in several Enterobacteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3299b3fddc5b2eccd0bcefb0b9cfa4aa
http://europepmc.org/articles/PMC3682690
http://europepmc.org/articles/PMC3682690