Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Amelia G. Langan"'
Autor:
Alisa M. Posner, Robin Striar, Anna Kathryn Rattray, Rudolph E. Tanzi, Changning Wang, Tyler Nicholas Meyer, Sepideh Afshar, Ping Bai, Shiqian Shen, Yan Liu, Can Zhang, Yu Lan, Amelia G. Langan
Publikováno v:
J Med Chem
We report the development of the first positron emission tomography (PET) radiotracer, [(18)F]CNY-07, based on a highly specific and potent RIPK1 inhibitor, Nec-1s, for RIPK1/necroptosis brain imaging in rodents. [(18)F]CNY-07 was synthesized through
Autor:
Gengyang Yuan, Darcy R. Tocci, Changning Wang, Stephen J. Haggarty, Zude Chen, Yan Liu, Hao Wang, Amelia G. Langan, Julia S. Zagaroli, Ping Bai, Robin Striar, Yu Lan, Sepideh Afshar, Debasis Patnaik
Publikováno v:
Journal of Medicinal Chemistry. 64:14745-14756
To better understand the role of bromodomain and extra-terminal domain (BET) proteins in epigenetic mechanisms, we developed a series of thienodiazepine-based derivatives and identified two compounds, 3a and 6a, as potent BET inhibitors. Further in v
Autor:
Ping Bai, Yan Liu, Yulong Xu, Robin Striar, Gengyang Yuan, Sepideh Afshar, Amelia G. Langan, Anna K. Rattray, Changning Wang
Publikováno v:
Bioorg Chem
The orexin receptors (OXRs) have been involved in multiple physiological and neuropsychiatric functions. Identification of PET imaging probes specifically targeting OXRs enables us to better understand the OX system. Seltorexant (JNJ-42847922) is a p
Autor:
Sepideh Afshar, Amelia G. Langan, Julia S. Zagaroli, Darcy R. Tocci, Ping Bai, Changning Wang, Robin Striar, Yan Liu, Yu Lan, Hao Wang, Gengyang Yuan
Publikováno v:
Bioconjugate chemistry. 32(8)
Two tandem bromodomains (BD1 and BD2) of bromodomain and extraterminal domain (BET) family proteins have shown distinct roles in mediating gene transcription and expression. Inhibitors that interact with a specific bromodomain may contribute to a spe
Autor:
Hallie Blevins, Yiming Xu, Robin Striar, Yan Liu, Darcy R. Tocci, Gengyang Yuan, Julia S. Zagaroli, Changning Wang, Amelia G. Langan, Shijun Zhang, Yulong Xu, Yu Lan, Can Zhang
Publikováno v:
Bioorg Med Chem Lett
We report herein the discovery of a positron emission tomography (PET) tracer for the (NOD)-like receptor protein 3 (NLRP3). Our recent medicinal chemistry campaign on developing sulfonamide-based NLRP3 inhibitors led to an analog, 1, with a methoxy