Characterization of emergent toxigenic M1UK Streptococcus pyogenes and associated sublineages

Autor: Ho Kwong Li, Xiangyun Zhi, Ana Vieira, Harry J. Whitwell, Amelia Schricker, Elita Jauneikaite, Hanqi Li, Ahmed Yosef, Ivan Andrew, Laurence Game, Claire E. Turner, Theresa Lamagni, Juliana Coelho, Shiranee Sriskandan

Publikováno v: Microbial Genomics. 9

Streptococcus pyogenes genotype emm1 is a successful, globally distributed epidemic clone that is regarded as inherently virulent. An emm1 sublineage, M1UK, that produces increased levels of SpeA toxin was associated with increased scarlet fever and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2034c804d541e9000b6c2ac48bccb10d
https://doi.org/10.1099/mgen.0.000994

Single-cell analysis of cardiogenesis reveals basis for organ level developmental defects

Autor: Casey A. Gifford, Amelia Schricker, Sanjeev S. Ranade, T. Yvanka de Soysa, Antonio del Sol, Deepak Srivastava, Yadong Huang, Satoshi Okawa, Srikanth Ravichandran, Hazel T. Salunga

Publikováno v: Nature

Organogenesis involves integration of diverse cell types; dysregulation of cell-type-specific gene networks results in birth defects, which affect 5% of live births. Congenital heart defects are the most common malformations, and result from disrupti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa1c9d1b661c28f94bc1da3ed14aada
http://europepmc.org/articles/PMC6719697

Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming

Autor: Reuben Thomas, Karishma Pratt, Kaitlen Samse-Knapp, Lin Ye, Ethan Radzinsky, Joke G. van Bemmel, Nicole Stone, Kathryn N. Ivey, Casey A. Gifford, Amelia Schricker, Tamer M.A. Mohamed, Pengzhi Yu, Deepak Srivastava, Katherine S. Pollard

Publikováno v: Cell stem cell, vol 25, iss 1
Cell Stem Cell
Stone, N R, Gifford, C A, Thomas, R, Pratt, K J B, Samse-Knapp, K, Mohamed, T M A, Radzinsky, E M, Schricker, A, Ye, L, Yu, P, van Bemmel, J G, Ivey, K N, Pollard, K S & Srivastava, D 2019, ' Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming ', Cell Stem Cell, vol. 25, no. 1, pp. 87-102.e9 . https://doi.org/10.1016/j.stem.2019.06.012

Ectopic expression of combinations of transcription factors (TFs) can drive direct lineage conversion, thereby reprogramming a somatic cell's identity. To determine the molecular mechanisms by which Gata4, Mef2c, and Tbx5 (GMT) induce conversion from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d33d2776d4d5a4bda36294362c2e3b
https://escholarship.org/uc/item/5063d4vp

Single-cell transcriptome analysis during cardiogenesis reveals basis for organ level developmental anomalies

Autor: Casey A. Gifford, Deepak Srivastava, T. Yvanka de Soysa, Antonio del Sol, Hazel T. Salunga, Amelia Schricker, Satoshi Okawa, Sanjeev S. Ranade, Srikanth Ravichandran, Yadong Huang

Organogenesis involves integration of myriad cell types with reciprocal interactions, each progressing through successive stages of lineage specification and differentiation. Establishment of unique gene networks within each cell dictates fate determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e01fe92eba33e4e03d36c273e64b3f5