A Prospective cohort study of zoonotic cutaneous leishmaniasis in tunisia: Clinical and Immunological features and immune correlates of protection.

Autor: Ikbel Naouar, Wafa Kammoun Rebai, Afif Ben Salah, Hind Bouguerra, Amine Toumi, Nabil Belhadj Hamida, Hechmi Louzir, Amel Meddeb-Garnaoui

Publikováno v: PLoS Neglected Tropical Diseases, Vol 17, Iss 12, p e0011784 (2023)

BackgroundThis study aimed to define immunological markers of exposure to L. major parasites and identify correlates of protection against infection.MethodsWe analyzed a cohort of 790 individuals at risk of developing ZCL living in endemic areas with

Externí odkaz: https://doaj.org/article/ce05921dc9224680848fa123c289f1f4

Leishmania major large RAB GTPase is highly immunogenic in individuals immune to cutaneous and visceral leishmaniasis

Autor: Rym Chamakh-Ayari, Mehdi Chenik, Ahmed Sahbi Chakroun, Narges Bahi-Jaber, Karim Aoun, Amel Meddeb-Garnaoui

Publikováno v: Parasites & Vectors, Vol 10, Iss 1, Pp 1-11 (2017)

Abstract Background We previously identified a Leishmania (L.) major large RAB GTPase (LmlRAB), a new atypical RAB GTPase protein. It is highly conserved in Leishmania species while displaying low level of homology with mammalian homologues. Leishman

Externí odkaz: https://doaj.org/article/a4bbec53984c44e3833803327d55c385

Immunomodulatory Effects of Four Leishmania infantum Potentially Excreted/Secreted Proteins on Human Dendritic Cells Differentiation and Maturation.

Autor: Wafa Markikou-Ouni, Sima Drini, Narges Bahi-Jaber, Mehdi Chenik, Amel Meddeb-Garnaoui

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143063 (2015)

Leishmania parasites and some molecules they secrete are known to modulate innate immune responses through effects on dendritic cells (DCs) and macrophages. Here, we characterized four Leishmania infantum potentially excreted/secreted recombinant pro

Externí odkaz: https://doaj.org/article/f8065f009d6d4b63894500a5f64ba8bb

Design of multi-epitope peptides containing HLA class-I and class-II-restricted epitopes derived from immunogenic Leishmania proteins, and evaluation of CD4+ and CD8+ T cell responses induced in cured cutaneous leishmaniasis subjects

Autor: Yasmine Messaoudi, Elodie Petitdidier, A. Kidar, Karim Aoun, Jean-Loup Lemesre, Julie Pagniez, Sarra Hamrouni, Rym Chamakh-Ayari, Rachel Bras-Gonçalves, Amel Meddeb-Garnaoui

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, 2020, 14 (3), pp.e0008093. ⟨10.1371/journal.pntd.0008093⟩
PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008093 (2020)

Human leishmaniasis is a public health problem worldwide for which the development of a vaccine remains a challenge. T cell-mediated immune responses are crucial for protection. Peptide vaccines based on the identification of immunodominant T cell ep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c589b954ab74a2c665af6d9e7878fc8
https://pubmed.ncbi.nlm.nih.gov/32176691

Effects of Leishmania major clones showing different levels of virulence on infectivity, differentiation and maturation of human dendritic cells

Autor: W. Markikou‐Ouni, Amel Meddeb-Garnaoui, Y. Ben Achour‐Chenik

Publikováno v: Clinical and Experimental Immunology. 169:273-280

Summary Leishmania parasites and dendritic cell interactions (DCs) play an essential role in initiating and directing T cell responses and influence disease evolution. These interactions may vary depending on Leishmania species and strains. To evalua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8587dba002c18b988e0b57fcb332d8
https://doi.org/10.1111/j.1365-2249.2012.04611.x