Výsledky vyhledávání - "Amel Guezguez"

Akademický článek

Laminin receptor 37/67LR regulates adhesion and proliferation of normal human intestinal epithelial cells.

Autor: Taoufik Khalfaoui, Jean-François Groulx, Georges Sabra, Amel GuezGuez, Nuria Basora, Patrick Vermette, Jean-François Beaulieu

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e74337 (2013)

Interactions between the cell basal membrane domain and the basement membrane are involved in several cell functions including proliferation, migration and differentiation. Intestinal epithelial cells can interact with laminin, a major intestinal bas

Externí odkaz: https://doaj.org/article/22c3f944133f4ff8bca0c361d5b5dec2

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Akademický článek

A concerted HIF-1α/MT1-MMP signalling axis regulates the expression of the 3BP2 adaptor protein in hypoxic mesenchymal stromal cells.

Autor: Sébastien Proulx-Bonneau, Amel Guezguez, Borhane Annabi

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e21511 (2011)

Increased plasticity, migratory and immunosuppressive abilities characterize mesenchymal stromal cells (MSC) which enable them to be active participants in the development of hypoxic solid tumours. Our understanding of the oncogenic adaptation of MSC

Externí odkaz: https://doaj.org/article/8bb222aef1044918ad532160a6e6b574

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Histone Deacetylase Inhibition Impairs Normal Intestinal Cell Proliferation and Promotes Specific Gene Expression

Autor: Jean-François Beaulieu, Aline Simoneau, Amel Guezguez, Marco Beauséjour, Alireza Roostaee, Emile Levy, Pierre H. Vachon

Publikováno v: Journal of Cellular Biochemistry

Mechanisms that maintain proliferation and delay cell differentiation in the intestinal crypt are not yet fully understood. We have previously shown the implication of histone methylation in the regulation of enterocytic differentiation. In this stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4826710dfe413717d9af1582dd61cc0a
http://europepmc.org/articles/PMC5014201

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Modulation of stemness in a human normal intestinal epithelial crypt cell line by activation of the WNT signaling pathway

Autor: Fréderic Paré, Amel Guezguez, Yannick D. Benoit, Jean-François Beaulieu, Nuria Basora

Publikováno v: Experimental Cell Research. 322(2):355-364

The small intestine consists of two histological compartments composed of the crypts and the villi. The function of the adult small intestinal epithelium is mediated by four different types of mature cells: enterocytes, goblet, enteroendocrine and Pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd508a5aa3862a5198762133a41dffa8

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Differential regulation of cell death in head and neck cell carcinoma through alteration of cholesterol levels in lipid rafts microdomains

Autor: Clara Bionda, Amel Guezguez, Delphine Poncet, Anne Athias, Dominique Ardail, Gersende Alphonse, Philippe Gambert, Claire Rodriguez-Lafrasse

Publikováno v: Biochemical Pharmacology. 75:761-772

Lipid rafts are cholesterol-enriched microdomains in the plasma membrane. They act as molecular platforms that spatially organize membrane receptor molecules and are involved in the transduction of various signaling pathways. We recently reported tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bfb3fa43bf6741822383d4c510f1d77
https://doi.org/10.1016/j.bcp.2007.10.004

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Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells

Autor: Lorraine J. Gudas, Marco Beauséjour, Jean-François Beaulieu, Mavee Witherspoon, Yannick D. Benoit, Kristian B. Laursen, Steven M. Lipkin, Amel Guezguez

Colorectal cancer is among the leading causes of cancer death in the USA. The polycomb repressive complex 2 (PRC2), including core components SUZ12 and EZH2, represents a key epigenetic regulator of digestive epithelial cell physiology and was previo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489b638941f4ef7c980a840092fcb1fe
https://europepmc.org/articles/PMC3880229/

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3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells

Autor: Xavier Mouska, Alice D. Baudot, Amel Guezguez, Robert Rottapel, Marcel Deckert, Virginie Prod'homme, Claudine Blin-Wakkach

Publikováno v: The Journal of biological chemistry. 285(27)

The adapter protein 3BP2 (also known as SH3BP2 and Abl SH3-binding protein 2) has been involved in leukocyte signaling and activation downstream immunoreceptors. Genetic studies have further associated 3BP2 mutations to the human disease cherubism an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2298c43ada64ee7b32c0841c102fd248
https://pubmed.ncbi.nlm.nih.gov/20439986

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