Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Amel Dudakovic"'
Autor:
Louis Dagneaux, Afton K. Limberg, Aaron R. Owen, Jacob W. Bettencourt, Amel Dudakovic, Banu Bayram, Naomi M. Gades, Joaquin Sanchez-Sotelo, Daniel J. Berry, Andre van Wijnen, Mark E. Morrey, Matthew P. Abdel
Publikováno v:
Bone & Joint Research, Vol 12, Iss 1, Pp 58-71 (2023)
AimsAs has been shown in larger animal models, knee immobilization can lead to arthrofibrotic phenotypes. Our study included 168 C57BL/6J female mice, with 24 serving as controls, and 144 undergoing a knee procedure to induce a contracture without os
Externí odkaz:
https://doaj.org/article/de744dfec56c45fd9615de3aba6bd83c
Autor:
Afton K. Limberg, Christopher G. Salib, Meagan E. Tibbo, Juan S. Vargas-Hernandez, Jacob W. Bettencourt, Banu Bayram, Charlotte E. Berry, Amel Dudakovic, Brad Bolon, Andre J. van Wijnen, Mark E. Morrey, Joaquin Sanchez-Sotelo, Daniel J. Berry, Jodi M. Carter, Matthew P. Abdel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Arthrofibrosis following total knee arthroplasty (TKA) is a debilitating condition typically diagnosed based on clinical findings. To gain insight into the histopathologic immune cell microenvironment of arthrofibrosis, we assessed the exten
Externí odkaz:
https://doaj.org/article/1c40645896924d1bb2bff3c1f5b012f5
Autor:
Roman Thaler, Farzaneh Khani, Ines Sturmlechner, Sharareh S. Dehghani, Janet M. Denbeigh, Xianhu Zhou, Oksana Pichurin, Amel Dudakovic, Sofia S. Jerez, Jian Zhong, Jeong-Heon Lee, Ramesh Natarajan, Ivo Kalajzic, Yong-hui Jiang, David R. Deyle, Eleftherios P. Paschalis, Barbara M. Misof, Tamas Ordog, Andre J. van Wijnen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
For decades vitamin C’s primary function in bone has been attributed to its involvement in collagen synthesis. Here, the authors uncover that vitamin C’s central role in bone is to globally orchestrate osteogenesis via epigenetic mechanisms.
Externí odkaz:
https://doaj.org/article/03ddd7fcf25c4309b04599c7af2fbd14
Autor:
Amel Dudakovic, Sofia Jerez, Padmini J. Deosthale, Janet M. Denbeigh, Christopher R. Paradise, Martina Gluscevic, Pengfei Zan, Dana L. Begun, Emily T. Camilleri, Oksana Pichurin, Farzaneh Khani, Roman Thaler, Jane B. Lian, Gary S. Stein, Jennifer J. Westendorf, Lilian I. Plotkin, Andre J. van Wijnen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract High-throughput microRNA sequencing was performed during differentiation of MC3T3-E1 osteoblasts to develop working hypotheses for specific microRNAs that control osteogenesis. The expression data show that miR-101a, which targets the mRNAs
Externí odkaz:
https://doaj.org/article/f5c778c9a9e84a5d9acbf3c478897543
Autor:
William H. Trousdale, Afton K. Limberg, Nicolas Reina, Christopher G. Salib, Roman Thaler, Amel Dudakovic, Daniel J. Berry, Mark E. Morrey, Joaquin Sanchez-Sotelo, Andre van Wijnen, Matthew P. Abdel
Publikováno v:
Bone & Joint Research, Vol 11, Iss 1, Pp 32-39 (2022)
Aims: Outcomes of current operative treatments for arthrofibrosis after total knee arthroplasty (TKA) are not consistently positive or predictable. Pharmacological in vivo studies have focused mostly on prevention of arthrofibrosis. This study used a
Externí odkaz:
https://doaj.org/article/5d96d38a567b4705bc27abac15bd54a8
Autor:
Ashley A. Krull, Deborah O. Setter, Tania F. Gendron, Sybil C. L. Hrstka, Michael J. Polzin, Joseph Hart, Amel Dudakovic, Nicolas N. Madigan, Allan B. Dietz, Anthony J. Windebank, Andre J. van Wijnen, Nathan P. Staff
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021)
Abstract Background Mesenchymal stromal cells (MSCs) have been studied with increasing intensity as clinicians and researchers strive to understand the ability of MSCs to modulate disease progression and promote tissue regeneration. As MSCs are used
Externí odkaz:
https://doaj.org/article/47692b6a9c6541b9a0f6a8f7dadecf99
Autor:
Petri Rummukainen, Kati Tarkkonen, Amel Dudakovic, Rana Al-Majidi, Vappu Nieminen-Pihala, Cristina Valensisi, R. David Hawkins, Andre J. van Wijnen, Riku Kiviranta
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Epigenetic mechanisms regulate osteogenic lineage differentiation of mesenchymal stromal cells. Histone methylation is controlled by multiple lysine demethylases and is an important step in controlling local chromatin structure and gene expression. H
Externí odkaz:
https://doaj.org/article/7426cb3eed9b46dfa425198e3ca407af
Autor:
Christopher R Paradise, Rodolfo E De La Vega, M Lizeth Galvan, Margarita E Carrasco, Roman Thaler, Andre J vanWijnen, Amel Dudakovic
Publikováno v:
JBMR Plus, Vol 5, Iss 10, Pp n/a-n/a (2021)
ABSTRACT Bromodomain (BRD) proteins are histone code interpreters that recognize acetylated lysines and link the dynamic state of chromatin with the transcriptional machinery. Here, we demonstrate that ablation of the Brd4 gene in primary mouse bone
Externí odkaz:
https://doaj.org/article/0f084c9fd5ba4ab08e548ed95f5d960f
Autor:
Zhihui Xie, Cody McGrath, Jeyantt Sankaran, Maya Styner, Sarah Little‐Letsinger, Amel Dudakovic, Andre J vanWijnen, Janet Rubin, Buer Sen
Publikováno v:
JBMR Plus, Vol 5, Iss 3, Pp n/a-n/a (2021)
ABSTRACT Use of the selective estrogen receptor modulator Tamoxifen (TAM) is a mainstay to induce conditional expression of Cre recombinase in transgenic laboratory mice. To excise β‐cateninfl/fl in 28‐day‐old male and female Prrx1‐CreER/β
Externí odkaz:
https://doaj.org/article/9020362feb41477088f97aef70886d37
Autor:
Mario Hevesi, Carlo A. Paggi, Joao F. Crispim, Wouter van Genechten, Janet M. Denbeigh, Nicholas J. Olson, Amel Dudakovic, Andre J. van Wijnen, Aaron J. Krych, Daniel B.F. Saris
Publikováno v:
Journal of Cartilage & Joint Preservation, Vol 1, Iss 1, Pp 100003- (2021)
Introduction: Improving ligament reconstruction biology may potentially be achieved through capturing autologous circulating factors such as vascular endothelial growth factor (VEGF) using commercially available biomaterials. Objectives: To evaluate
Externí odkaz:
https://doaj.org/article/3100b063cf614b00bd764d80996cb7e4