Výsledky vyhledávání

Integration of chromatin accessibility and gene expression data with cisREAD reveals a switch from PU.1/SPIB-driven to AP-1-driven gene regulation during B cell activation

Autor: Amber M.L. Emmett, Amel Saadi, Matthew A. Care, Gina M. Doody, Reuben M. Tooze, David R. Westhead

Human B cell differentiation into antibody secreting plasma cells is a critical process in the adaptive immune response, whose regulation at the genetic level remains incompletely understood. To reveal the temporal sequence of transcription factor dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1dfdb1cbb52bf63cdc4fe499851e83cf
https://doi.org/10.1101/2023.01.09.522862

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Akademický článek

Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor

Autor: Hisham Mohammed, Clive D’Santos, Aurelien A. Serandour, H. Raza Ali, Gordon D. Brown, Alan Atkins, Oscar M. Rueda, Kelly A. Holmes, Vasiliki Theodorou, Jessica L.L. Robinson, Wilbert Zwart, Amel Saadi, Caryn S. Ross-Innes, Suet-Feung Chin, Suraj Menon, John Stingl, Carlo Palmieri, Carlos Caldas, Jason S. Carroll

Publikováno v: Cell Reports, Vol 3, Iss 2, Pp 342-349 (2013)

Estrogen receptor-α (ER) is the driving transcription factor in most breast cancers, and its associated proteins can influence drug response, but direct methods for identifying interacting proteins have been limited. We purified endogenous ER using

Externí odkaz: https://doaj.org/article/82f5e9bc92054011ab7cc4d25829df4b

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A dichotomy of gene regulatory associations during the activated B-cell to plasmablast transition

Autor: Muna Al-Maskari, Gina M. Doody, Matthew A. Care, Mario Cocco, Reuben Tooze, Amel Saadi

Publikováno v: Life Science Alliance

As human B-cells differentiate, IRF4 switches occupancy and acquires CTCF colocalisation and IRF4 regulatory output diverts from cell activation to plasma cell state genes in conjunction with XBP1, whereas BLIMP1 represses activation.
The activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b53e8ceb561d0e7f196dceadc6c05e5
https://pubmed.ncbi.nlm.nih.gov/32843533

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Epigenetic control of the protocadherin-gamma locus provides a potential source of cell surface codes in B cell differentiation

Autor: Nicole L McDermott, Amel Saadi, Mario Cocco, Matthew Care, Ruth de Tute, Roger Owen, Gina Doody, Reuben Tooze

Publikováno v: The Journal of Immunology. 204:153.17-153.17

Cellular adhesion plays an important role in determining homing and retention of cells to specific locations. Antibody-secreting plasma cells (PCs) depend on access to niche microenvironments for survival, but the factors that control the adhesion be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::922e6423d74d2dd23206b99509153454
https://doi.org/10.4049/jimmunol.204.supp.153.17

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Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus

Autor: Rebecca C. Fitzgerald, Massimiliano di Pietro, Pierre Lao-Sirieix, Amel Saadi, Shelagh Boyle, Andrew Cassidy, Ragnhild Eskeland, Dani Castillo

Publikováno v: Proceedings of the National Academy of Sciences. 109:9077-9082

Barrett esophagus (BE) is a human metaplastic condition that is the only known precursor to esophageal adenocarcinoma. BE is characterized by a posterior intestinal-like phenotype in an anterior organ and therefore it is reminiscent of homeotic trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd98b127469abcc0c475b60498004475
https://doi.org/10.1073/pnas.1116933109

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Nitric oxide-mediated invasion in Barrett's high-grade dysplasia and adenocarcinoma

Autor: Pierre Lao-Sirieix, M O'Donovan, Amel Saadi, Nicholas B. Shannon, Rebecca C. Fitzgerald, Nicholas J. Clemons, C. E. Walker, Lakshi R. Abeyratne

Publikováno v: Carcinogenesis. 31:1669-1675

Nitric oxide (NO) has been shown to induce double strand DNA breaks in Barrett's oesophagus (BO) and in other cancers has a role in invasion. The specific aims of this study were to investigate whether NO can induce invasion in cells representative o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7169fbcf31f8bd22f4a50cb93856efc
https://doi.org/10.1093/carcin/bgq130

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Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers

Autor: Chunsheng Zhang, Maria O'Donovan, Frances R. Balkwill, Marco Novelli, Vicki Save, Amel Saadi, Madhumita Das, Pierre Lao-Sirieix, Nicholas J. Clemons, James S. Hardwick, Rebecca C. Fitzgerald, Elaine C. Walker, Nicholas B. Shannon

Publikováno v: Proceedings of the National Academy of Sciences. 107:2177-2182

The stromal compartment is increasingly recognized to play a role in cancer. However, its role in the transition from preinvasive to invasive disease is unknown. Most gastrointestinal tumors have clearly defined premalignant stages, and Barrett’s e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9da4d8fab344be3178bdf123934938
https://doi.org/10.1073/pnas.0909797107

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