Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Amel, Ben Saad"'
1
Akademický článek
Identification of new correctors for traffic-defective ABCB4 variants by a high-content screening approach
Autor: Mounia Lakli, Julie Dumont, Virginie Vauthier, Julie Charton, Veronica Crespi, Manon Banet, Yosra Riahi, Amel Ben Saad, Elodie Mareux, Martine Lapalus, Emmanuel Gonzales, Emmanuel Jacquemin, Florent Di Meo, Benoit Deprez, Florence Leroux, Thomas Falguières
Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract ABCB4 is located at the canalicular membrane of hepatocytes and is responsible for the secretion of phosphatidylcholine into bile. Genetic variations of this transporter are correlated with rare cholestatic liver diseases, the most severe be
Externí odkaz: https://doaj.org/article/15d3c2a95c39433cb086203c92b4dc08
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2
Akademický článek
In vitro functional rescue by ivacaftor of an ABCB11 variant involved in PFIC2 and intrahepatic cholestasis of pregnancy
Autor: Elodie Mareux, Martine Lapalus, Amel Ben-Saad, Isabelle Callebaut, Thomas Falguières, Emmanuel Gonzales, Emmanuel Jacquemin
Publikováno v: Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-4 (2021)
Abstract Background ABCB11 variations are responsible for a spectrum of rare liver diseases, including progressive familial intrahepatic cholestasis type 2 (PFIC2) and intrahepatic cholestasis of pregnancy (ICP). Current medical treatment of these co
Externí odkaz: https://doaj.org/article/2224e9e12283412f8afa4558224ab794
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3
Akademický článek
MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression
Autor: Alix Bruneau, Jean-Louis Delaunay, Anne-Marie Durand-Schneider, Virginie Vauthier, Amel Ben Saad, Lynda Aoudjehane, Haquima El Mourabit, Romain Morichon, Thomas Falguières, Jérémie Gautheron, Chantal Housset, Tounsia Aït-Slimane
Publikováno v: Cells, Vol 11, Iss 4, p 617 (2022)
ABCB4, is an adenosine triphosphate-binding cassette (ABC) transporter localized at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine secretion into bile. Gene variations of ABCB4 cause different types of liver diseases,
Externí odkaz: https://doaj.org/article/1d4ade379e9b40148174424e5d1942ed
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4
Single cell transcriptomic landscapes of human liver organoids stratify models of non-alcoholic fatty liver disease
Autor: Anja Hess, Stefan D. Gentile, Amel Ben Saad, Raza-Ur Rahman, Tim Habboub, Alan C. Mullen
SummaryNon-alcoholic fatty liver disease (NAFLD) is a rapidly growing cause of morbidity with few treatment options available. Thus, accuratein vitrosystems to test new therapies are indispensable. Recently, human liver organoid (HLO) NAFLD models ha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ffb0d4f8b4aad8c6580a0154698f413
https://doi.org/10.1101/2022.07.19.500693
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6
In vitro functional rescue by ivacaftor of an ABCB11 variant involved in PFIC2 and intrahepatic cholestasis of pregnancy
Autor: Isabelle Callebaut, Martine Lapalus, Emmanuel Jacquemin, Emmanuel Gonzales, Elodie Mareux, Amel Ben-Saad, Thomas Falguières
Publikováno v: Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-4 (2021)
Orphanet Journal of Rare Diseases, BioMed Central, 2021, 16 (1), ⟨10.1186/s13023-021-02125-4⟩
Orphanet Journal of Rare Diseases, 2021, 16 (1), ⟨10.1186/s13023-021-02125-4⟩
Background ABCB11 variations are responsible for a spectrum of rare liver diseases, including progressive familial intrahepatic cholestasis type 2 (PFIC2) and intrahepatic cholestasis of pregnancy (ICP). Current medical treatment of these conditions
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614bdc2090d46fd5182ed9c95e581ced
https://pubmed.ncbi.nlm.nih.gov/34794484
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7
Effect of CFTR correctors on the traffic and the function of intracellularly retained ABCB4 variants
Autor: Ágota Tóth, Emmanuel Jacquemin, Isabelle Garcin, Jean-Louis Delaunay, Chantal Housset, Florent Di Meo, Angelika Janaszkiewicz, Alix Bruneau, Thomas Falguières, Martine Lapalus, Anne-Marie Durand-Schneider, Tounsia Aït-Slimane, Elodie Mareux, Emmanuel Gonzales, Virginie Vauthier, Amel Ben Saad
Publikováno v: Liver International
Liver International, Wiley-Blackwell, 2021, 41 (6), pp.1344-1357. ⟨10.1111/liv.14839⟩
Liver International, 2021, 41 (6), pp.1344-1357. ⟨10.1111/liv.14839⟩
International audience; Background & aim: ABCB4 is expressed at the canalicular membrane of hepatocytes. This ATP-binding cassette (ABC) transporter is responsible for the secretion of phosphatidylcholine into bile canaliculi. Missense genetic variat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1d478a09ed70ab74550169e6e80f1e
https://hal.sorbonne-universite.fr/hal-03263358/document
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8
Molecular Regulation of Canalicular ABC Transporters
Autor: Amel, Ben Saad, Alix, Bruneau, Elodie, Mareux, Martine, Lapalus, Jean-Louis, Delaunay, Emmanuel, Gonzales, Emmanuel, Jacquemin, Tounsia, Aït-Slimane, Thomas, Falguières
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2021, 22 (4), pp.2113. ⟨10.3390/ijms22042113⟩
International Journal of Molecular Sciences, 2021, 22 (4), pp.2113. ⟨10.3390/ijms22042113⟩
International Journal of Molecular Sciences, Vol 22, Iss 2113, p 2113 (2021)
International audience; The ATP-binding cassette (ABC) transporters expressed at the canalicular membrane of hepatocytes mediate the secretion of several compounds into the bile canaliculi and therefore play a key role in bile secretion. Among these
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::80f29677e693bdb3225ad7ecc4a758a5
https://hal.sorbonne-universite.fr/hal-03163529
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9
Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models
Autor: Thomas Falguières, Chantal Housset, Tounsia Aït-Slimane, Nassima Oumata, Amel Ben Saad, Laurent Meijer, Alix Bruneau, Jonathan Elie, Jean-Louis Delaunay, Virginie Vauthier, Anne-Marie Durand-Schneider
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Adenosine triphosphate binding cassette transporter, subfamily B member 4 (ABCB4) is the transporter of phosphatidylcholine at the canalicular membrane of hepatocytes. ABCB4 deficiency, due to genetic variations, is responsible for progressive famili
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6d2c91321b976602dffd674b864ff8
https://doi.org/10.1038/s41598-019-43111-y
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