Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Ameeta Kelekar"'
Autor:
Yan Yan, Karl N. Krecke, Aditi S. Bapat, Tingyuan Yang, Michael W. Lopresti, Douglas G. Mashek, Ameeta Kelekar
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-10 (2021)
Abstract PHLPP2 is a member of the PHLPP family of phosphatases, known to suppress cell growth by inhibiting proliferation or promoting apoptosis. Oncogenic kinases Akt, S6K, and PKC, and pro-apoptotic kinase Mst1, have been recognized as functional
Externí odkaz:
https://doaj.org/article/8236c7c1a446421294f9a93f782993b1
Autor:
Maria I. Matias, Carmen S. Yong, Amir Foroushani, Chloe Goldsmith, Cédric Mongellaz, Erdinc Sezgin, Kandice R. Levental, Ali Talebi, Julie Perrault, Anais Rivière, Jonas Dehairs, Océane Delos, Justine Bertand-Michel, Jean-Charles Portais, Madeline Wong, Julien C. Marie, Ameeta Kelekar, Sandrina Kinet, Valérie S. Zimmermann, Ilya Levental, Laurent Yvan-Charvet, Johannes V. Swinnen, Stefan A. Muljo, Hector Hernandez-Vargas, Saverio Tardito, Naomi Taylor, Valérie Dardalhon
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109911- (2021)
Summary: Suppressive regulatory T cell (Treg) differentiation is controlled by diverse immunometabolic signaling pathways and intracellular metabolites. Here we show that cell-permeable α-ketoglutarate (αKG) alters the DNA methylation profile of na
Externí odkaz:
https://doaj.org/article/0c8c5ea249b7400aa1ce379f1a846ac3
Autor:
Stephen C. Jameson, Henrique Borges da Silva, Brandon J. Burbach, Ameeta Kelekar, Tingyuan Yang, Stephen O'Flanagan, Bruna de Gois Macedo, Maggie H. Zhou, Changwei Peng, Kelsey M. Wanhainen
Supplementary Table from P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a15e65154193da79abb5e44be598f3a
https://doi.org/10.1158/2326-6066.22544783.v1
https://doi.org/10.1158/2326-6066.22544783.v1
Autor:
Stephen C. Jameson, Henrique Borges da Silva, Brandon J. Burbach, Ameeta Kelekar, Tingyuan Yang, Stephen O'Flanagan, Bruna de Gois Macedo, Maggie H. Zhou, Changwei Peng, Kelsey M. Wanhainen
Expression of the purinergic receptor P2RX7 by CD8+ T cells promotes the generation of memory populations following acute infections. However, data suggest that P2RX7 may limit the efficacy of antitumor responses. Herein, we show that P2RX7 is benefi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5b879024930683cdb576cb960cf046
https://doi.org/10.1158/2326-6066.c.6550745
https://doi.org/10.1158/2326-6066.c.6550745
Autor:
Stephen C. Jameson, Henrique Borges da Silva, Brandon J. Burbach, Ameeta Kelekar, Tingyuan Yang, Stephen O'Flanagan, Bruna de Gois Macedo, Maggie H. Zhou, Changwei Peng, Kelsey M. Wanhainen
Supplementary Figure from P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68655fb1fc6770a7e3567ff2292654ec
https://doi.org/10.1158/2326-6066.22544786.v1
https://doi.org/10.1158/2326-6066.22544786.v1
Autor:
Aditi S. Bapat, Karl N. Krecke, Douglas G. Mashek, Ameeta Kelekar, Michael W. Lopresti, Tingyuan Yang, Yan Yan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
PHLPP2 is a member of the PHLPP family of phosphatases, known to suppress cell growth by inhibiting proliferation or promoting apoptosis. Oncogenic kinases Akt, S6K, and PKC, and pro-apoptotic kinase Mst1, have been recognized as functional targets o
Publikováno v:
Apoptosis
Leucine-rich alpha-2-glycoprotein-1 (LRG1) has been shown to compete with apoptosis activating factor-1 (Apaf-1) for binding cytochrome c (Cyt c) and could play a role in inhibition of apoptosis. Employing MCF-7 breast cancer cells, we report that in
Autor:
Julie Perrault, Anais Rivière, Chloe Goldsmith, Jonas Dehairs, Cédric Mongellaz, Laurent Yvan-Charvet, Naomi Taylor, Valérie S. Zimmermann, Saverio Tardito, Maria I. Matias, Valerie Dardalhon, Océane Delos, Amir Foroushani, Kandice R. Levental, Stefan A. Muljo, Sandrina Kinet, Ilya Levental, Hector Hernandez-Vargas, Ali Talebi, Jean-Charles Portais, Justine Bertand-Michel, Madeline Wong, Ameeta Kelekar, Julien C. Marie, Johannes V. Swinnen, Carmen S M Yong, Erdinc Sezgin
Publikováno v:
Cell Reports
Cell Reports, 2021, 37 (5), pp.109911. ⟨10.1016/j.celrep.2021.109911⟩
Cell Rep
Cell Reports, Vol 37, Iss 5, Pp 109911-(2021)
Cell Reports, 2021, 37 (5), pp.109911. ⟨10.1016/j.celrep.2021.109911⟩
Cell Rep
Cell Reports, Vol 37, Iss 5, Pp 109911-(2021)
Suppressive regulatory T cell (Treg) differentiation is controlled by diverse immunometabolic signaling pathways and intracellular metabolites. Here we show that cell-permeable α-ketoglutarate (αKG) alters the DNA methylation profile of naive CD4 T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a0285e83f2c785c903977fe07dec51
https://lirias.kuleuven.be/handle/20.500.12942/691431
https://lirias.kuleuven.be/handle/20.500.12942/691431
Autor:
Kelsey M. Wanhainen, Changwei Peng, Maggie H. Zhou, Bruna de Gois Macedo, Stephen O'Flanagan, Tingyuan Yang, Ameeta Kelekar, Brandon J. Burbach, Henrique Borges da Silva, Stephen C. Jameson
Publikováno v:
Cancer Immunol Res
Expression of the purinergic receptor P2RX7 by CD8+ T cells promotes the generation of memory populations following acute infections. However, data suggest that P2RX7 may limit the efficacy of antitumor responses. Herein, we show that P2RX7 is benefi
Autor:
Jonathan S. Serody, Ameeta Kelekar, Brent H. Koehn, Brian T. Fife, Laurence A. Turka, Asim Saha, Govindarajan Thangavelu, Keli L. Hippen, Sudha Kumari, Angela Panoskaltsis-Mortari, Andrew Kemal Kirchmeier, Mark J. Osborn, Cameron McDonald-Hyman, David H. Munn, Jason S. Mitchell, Guoan Zhang, Bruce R. Blazar, Colby J. Feser, Michael Loschi, Michael L. Dustin, Jiqiang Lin, James E. Muller, Thomas A. Neubert, Hongbo Chi, Michelle J. Smith, Dawn K. Reichenbach
Publikováno v:
Journal of Clinical Investigation. 128:4604-4621
Regulatory T cells (Tregs) are critical for maintaining immune homeostasis. However, current Treg immunotherapies do not optimally treat inflammatory diseases in patients. Understanding the cellular processes that control Treg function may allow for