Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Ameet S. Sengar"'
Autor:
Eleonora Maino, Ori Scott, Samar Z. Rizvi, Wing Suen Chan, Shagana Visuvanathan, Youssif Ben Zablah, Hongbin Li, Ameet S. Sengar, Michael W. Salter, Zhengping Jia, Janet Rossant, Ronald D. Cohn, Bin Gu, Evgueni A. Ivakine
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/102714651e424d538637bc0d58cdac43
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-7 (2020)
Abstract N-methyl-d-aspartate receptors (NMDARs) are excitatory glutamatergic receptors that are fundamental for many neuronal processes, including synaptic plasticity. NMDARs are comprised of four subunits derived from heterogeneous subunit families
Externí odkaz:
https://doaj.org/article/6d132272e69a496dbf01718440b1c319
Autor:
Ameet S. Sengar, Hongbin Li, Wenbo Zhang, Celeste Leung, Arun K. Ramani, Ner Mu Saw, Yongqian Wang, YuShan Tu, P. Joel Ross, Stephen W. Scherer, James Ellis, Michael Brudno, Zhengping Jia, Michael W. Salter
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4285-4294.e5 (2019)
Summary: NMDA receptors (NMDARs) are critical for physiological synaptic plasticity, learning, and memory and for pathological plasticity and neuronal death. The GluN1 subunit is encoded by a single gene, GRIN1, with 8 splice variants, but whether th
Externí odkaz:
https://doaj.org/article/1a3dd25900664f94b5b66e9ce5d99a4e
Autor:
Eleonora Maino, Ori Scott, Samar Z. Rizvi, Shagana Visuvanathan, Youssif Ben Zablah, Hongbin Li, Ameet S. Sengar, Michael W. Salter, Zhengping Jia, Janet Rossant, Ronald D. Cohn, Bin Gu, Evgueni A. Ivakine
MECP2 duplication syndrome (MDS) is a neurodevelopmental disorder caused by tandem duplication of theMECP2locus and its surrounding genes, includingIRAK1. Current MDS mouse models involve transgenic expression ofMECP2only, limiting their applicabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a01d3f8950a8e3cccd379007546a6c4c
https://doi.org/10.1101/2023.02.07.527511
https://doi.org/10.1101/2023.02.07.527511
Autor:
Shahrzad Ghazisaeidi, Milind M. Muley, YuShan Tu, Mahshad Kolahdouzan, Ameet S. Sengar, Arun K. Ramani, Michael Brudno, Michael W. Salter
Background and Purpose: Chronic pain is a devastating problem affecting 1 in 5 individuals around the globe, with neuropathic pain the most debilitating and poorly treated type of chronic pain. Advances in transcriptomics and data mining have contrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8511be5eea8a215fde7606cfe1231016
https://doi.org/10.22541/au.166325658.84625800/v1
https://doi.org/10.22541/au.166325658.84625800/v1
Autor:
Vishaal Rajani, Lu Han, Hongbin Li, James E. Cooke, Michael W. Salter, Danielle Chung, Ameet S. Sengar
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance N-methyl-D-aspartate receptors (NMDARs), which are critical in the brain, are increasingly being shown to signal without ion flux (i.e., “metabotropically”). What controls the metabotropic function of NMDARs is unknown. We discovered
Autor:
Michael W. Salter, Lu Han, Ameet S. Sengar, Danielle Chung, Hongbin Li, James E. Cooke, Vishaal Rajani
SummaryN-methyl-D-aspartate receptors (NMDARs), a principal subtype of excitatory neurotransmitter receptor, are composed as tetrameric assemblies of two glycine-binding GluN1 subunits and two glutamate-binding GluN2 subunits. Gating of the NMDARs re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ed1efdfad76c1048d92df8f2bd66fc4
https://doi.org/10.1101/2020.12.18.423454
https://doi.org/10.1101/2020.12.18.423454
Autor:
Katherine Halievski, Ameet S Sengar, Janice Hicks, Jillian Haight, Michael W Salter, Benjamin E Steinberg
Publikováno v:
Molecular Pain. 18:174480692210766
T lymphocytes are increasingly implicated in pain signaling. A subset of T lymphocytes, termed TChAT, express the rate-limiting enzyme for acetylcholine (ACh) production, choline acetyltransferase (ChAT), and mediate numerous physiological functions.
Publikováno v:
Ageing Research Reviews. 40:84-94
The immune system is now considered a major factor in Alzheimer Disease (AD). This review seeks to demonstrate how various aspects of the immune system, both in the brain and peripherally, interact to contribute to AD. We highlight classical nervous
Publikováno v:
Neuropharmacology. 193:108615
The Src family kinases (SFKs) are cytoplasmic non-receptor tyrosine kinases involved in multiple signalling pathways. In the central nervous system (CNS), SFKs are key regulators of N-methyl- d -aspartate receptor (NMDAR) function and major points of