Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Ameet A Chimote"'
Autor:
Laura Conforti, Edith M Janssen, Hannah S Newton, Vaibhavkumar S Gawali, Ameet A Chimote, Maria A Lehn, Sarah M Palackdharry, Benjamin H Hinrichs, Roman Jandarov, David Hildeman, Trisha M Wise-Draper
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Immunotherapy has emerged as a promising treatment modality for head and neck squamous cell carcinoma (HNSCC). Pembrolizumab, an anti-programmed death 1 antibody, is an immunotherapy agent currently approved for metastatic HNSCC and curati
Externí odkaz:
https://doaj.org/article/65aba8cacdf74f5d84b824a04f706c53
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43859 (2012)
The migration of T lymphocytes is an essential part of the adaptive immune response as T cells circulate around the body to carry out immune surveillance. During the migration process T cells polarize, forming a leading edge at the cell front and a u
Externí odkaz:
https://doaj.org/article/6115844ae3d44e51b18f24cf2cc78111
Autor:
Ameet A. Chimote, Abdulaziz O. Alshwimi, Martina Chirra, Vaibhavkumar S. Gawali, Margaret V. Powers-Fletcher, Kristin M. Hudock, Laura Conforti
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSevere COVID-19 is characterized by cytokine storm, an excessive production of proinflammatory cytokines that contributes to acute lung damage and death. Dexamethasone is routinely used to treat severe COVID-19 and has been shown to reduc
Externí odkaz:
https://doaj.org/article/66e2924b6b58480db9a76dfa664afe6a
Autor:
Ameet A. Chimote, Vaibhavkumar S. Gawali, Hannah S. Newton, Trisha M. Wise-Draper, Laura Conforti
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The limited ability of cytotoxic CD8+ T cells to infiltrate solid tumors and function within the tumor microenvironment presents a major roadblock to effective immunotherapy. Ion channels and Ca2+-dependent signaling events control the activity of T
Externí odkaz:
https://doaj.org/article/6de5d9af9a4947339b10f27bd2a1fae0
Autor:
Laura Conforti, Keith A. Casper, Trisha Wise-Draper, Brittany N. Gleich, Alexandros M. Sfyris, Peter Hajdu, Ameet A. Chimote
Histopathology analysis of Hematoxylin-Eosin stained slides from HNC tumor and normal tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593b9f92c5673a0796ee300421a2c1ce
https://doi.org/10.1158/0008-5472.22412333.v1
https://doi.org/10.1158/0008-5472.22412333.v1
Autor:
Laura Conforti, Keith A. Casper, Trisha Wise-Draper, Brittany N. Gleich, Alexandros M. Sfyris, Peter Hajdu, Ameet A. Chimote
Quantitation of Kv1.3 protein expression in CD8+ TIL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280263fab638db6d8e591cb41ee0ae3c
https://doi.org/10.1158/0008-5472.22412345
https://doi.org/10.1158/0008-5472.22412345
Autor:
Laura Conforti, Keith A. Casper, Trisha Wise-Draper, Brittany N. Gleich, Alexandros M. Sfyris, Peter Hajdu, Ameet A. Chimote
Methods for Supplementary Figure S6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d41a5a82c03f46902e6941132915d3c
https://doi.org/10.1158/0008-5472.22412336.v1
https://doi.org/10.1158/0008-5472.22412336.v1
Publikováno v:
J Biomol Tech
Research Shared (core) Facilities (RSF) operate as centers of expertise and help to accelerate basic and translational science. A centralized platform for unified ordering, equipment reservation, and the billing of services using an integrated softwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563a96933f0241f36492faded7b21c69
https://europepmc.org/articles/PMC10078833/
https://europepmc.org/articles/PMC10078833/
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 133-143 (2021)
In solid malignancies, including head and neck squamous cell carcinoma (HNSCC), the immunosuppressive molecule adenosine, which accumulates in the tumor, suppresses cytotoxic CD8+ T cell functions including chemotaxis and tumor infiltration. Adenosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bd722758f7f0642185642751493dde
https://doi.org/10.1016/j.omtm.2021.03.001
https://doi.org/10.1016/j.omtm.2021.03.001
Autor:
Martina Chirra, Hannah S. Newton, Vaibhavkumar S. Gawali, Trisha M. Wise-Draper, Ameet A. Chimote, Laura Conforti
Publikováno v:
Cancers. 14(15)
Competent antitumor immune cells are fundamental for tumor surveillance and combating active cancers. Once established, tumors generate a tumor microenvironment (TME) consisting of complex cellular and metabolic elements that serve to suppress the fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4ac646ce8cc2c7cbea1c72de14c746
https://pubmed.ncbi.nlm.nih.gov/35892822
https://pubmed.ncbi.nlm.nih.gov/35892822