Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ameeq Ul Mushtaq"'
Autor:
Dae Gyu Kim, Yongseok Choi, Yuno Lee, Semi Lim, Jiwon Kong, JaeHa Song, Younah Roh, Dipesh S. Harmalkar, Kwanshik Lee, Ja-il Goo, Hye Young Cho, Ameeq Ul Mushtaq, Jihye Lee, Song Hwa Park, Doyeun Kim, Byung Soh Min, Kang Young Lee, Young Ho Jeon, Sunkyung Lee, Kyeong Lee, Sunghoon Kim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Direct targeting of oncogenic KRAS activity is a challenge. Here the authors report that a splice variant of AIMP2, AIMP2-DX2, enhances KRAS stability by blocking ubiquitin-mediated degradation of KRAS via the E3 ligase, Smurf2, and identify a chemic
Externí odkaz:
https://doaj.org/article/f7b60731b1ef420298a16914d07b8a55
Autor:
Ameeq Ul Mushtaq, Jörgen Ådén, Luke A. Clifton, Hanna Wacklin-Knecht, Mario Campana, Artur P. G. Dingeldein, Cecilia Persson, Tobias Sparrman, Gerhard Gröbner
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Through neutron reflectometry and NMR spectroscopy studies, Mushtaq et al study the full-length Bcl-2 protein reconstituted in lipid bilayers. They find that, in contrast to previously studied truncated, soluble protein versions, intact Bcl-2 is main
Externí odkaz:
https://doaj.org/article/04e38e0553dd4095833d3e485d2fc850
Autor:
Roshan Jha, Hye Young Cho, Ameeq Ul Mushtaq, Kiho Lee, Dae Gyu Kim, Sunghoon Kim, Young Ho Jeon
Publikováno v:
Data in Brief, Vol 11, Iss C, Pp 533-536 (2017)
AIMP2-DX2 is a splicing variant of AIMP2 protein which has been implicated in human lung cancer and chemoresistance of ovarian cancer (J.W. Choi, D.G. Kim, A.E. Lee, H.R. Kim, J.Y. Lee, N.H. Kwon, et al., 2011; J.W. Choi, J.W. Lee, J.K. Kim, H.K. Jeo
Externí odkaz:
https://doaj.org/article/ed7d5102d0074826bd1dbd6b0852f647
Publikováno v:
Molecules, Vol 26, Iss 5, p 1467 (2021)
Evasion from programmed cell death (apoptosis) is the main hallmark of cancer and a major cause of resistance to therapy. Many tumors simply ensure survival by over-expressing the cell-protecting (anti-apoptotic) Bcl-2 membrane protein involved in ap
Externí odkaz:
https://doaj.org/article/50073a62cf95478b9bef02fb0a75a9af
Autor:
Luke A. Clifton, Hanna P. Wacklin-Knecht, Jörgen Ådén, Ameeq Ul Mushtaq, Tobias Sparrman, Gerhard Gröbner
Cellular clearance by apoptosis is essential in life. In its intrinsic (mitochondrial) pathway apoptotic members of the Bcl-2 (B cell CLL/lymphoma-2) protein family, such as Bax (Bcl-2-associated X) protein, perforate the mitochondrial outer membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edf19a2fcb241b54956520fa93aaf5be
https://doi.org/10.1101/2022.11.01.514672
https://doi.org/10.1101/2022.11.01.514672
Programmed mammalian cell death (apoptosis) is an essential mechanism in life that tightly regulates embryogenesis and removal of dysfunctional cells. In its intrinsic (mitochondrial) pathway, opposing members of the Bcl-2 (B cell lymphoma 2) protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8566fd48a7d92554c7aed8d1804575bc
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-201021
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-201021
Autor:
Luke A. Clifton, Ameeq Ul Mushtaq, Jörgen Åden, Tobias Sparrman, Hanna Wacklin-Knecht, Gerhard Grobner
Publikováno v:
Biophysical Journal. 122:232a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc4f1f7b90449970bbe7d641c3b2eae0
https://doi.org/10.1016/j.bpj.2022.11.1366
https://doi.org/10.1016/j.bpj.2022.11.1366
Autor:
Hoi Kyoung Kim, Myung Hee Kim, Minkyoung Kim, Won Suk Yang, Hye Young Cho, Aneesh Sivaraman, Jihye Lee, Semi Lim, Youngjin Lee, Young Ho Jeon, Kyeong Lee, Ameeq Ul Mushtaq, Deepak Bhattarai, Dae Gyu Kim, Younah Roh, Se Young Son, Sunghoon Kim
Publikováno v:
Nature Chemical Biology. 16:31-41
A tumorigenic factor, AIMP2 lacking exon 2 (AIMP2-DX2), is often upregulated in many cancers. However, how its cellular level is determined is not understood. Here, we report heat-shock protein HSP70 as a critical determinant for the level of AIMP2-D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2051a4bea5ec2df591dd741b027a8065
https://doi.org/10.1038/s41589-019-0415-2
https://doi.org/10.1038/s41589-019-0415-2
Publikováno v:
Biomolecular NMR assignments. 16(1)
The Hsp100 family member ClpB is a protein disaggregase which solubilizes and reactivates stress-induced protein aggregates in cooperation with the DnaK/Hsp70 chaperone system. In the pathogenic bacterium Francisella tularensis, ClpB is involved in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7401789d965ad94d527f30afeecbfc
https://pubmed.ncbi.nlm.nih.gov/34985724
https://pubmed.ncbi.nlm.nih.gov/34985724
Autor:
Dae Gyu Kim, Yongseok Choi, Yuno Lee, Semi Lim, Jiwon Kong, JaeHa Song, Younah Roh, Dipesh S. Harmalkar, Kwanshik Lee, Ja-il Goo, Hye Young Cho, Ameeq Ul Mushtaq, Jihye Lee, Song Hwa Park, Doyeun Kim, Byung Soh Min, Kang Young Lee, Young Ho Jeon, Sunkyung Lee, Kyeong Lee, Sunghoon Kim
Publikováno v:
Nature communications, vol 13, iss 1
Recent development of the chemical inhibitors specific to oncogenic KRAS (Kirsten Rat Sarcoma 2 Viral Oncogene Homolog) mutants revives much interest to control KRAS-driven cancers. Here, we report that AIMP2-DX2, a variant of the tumor suppressor AI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d567b43de4da8480147f105d233d323
https://pubmed.ncbi.nlm.nih.gov/35546148
https://pubmed.ncbi.nlm.nih.gov/35546148