Stapled Peptides Inhibitors: A New Window for Target Drug Discovery

Autor: Ameena M. Ali, Jack Atmaj, Niels Van Oosterwijk, Matthew R. Groves, Alexander Dömling

Publikováno v: Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 263-281 (2019)

Protein-protein interaction (PPI) is a hot topic in clinical research as protein networking has a major impact in human disease. Such PPIs are potential drugs targets, leading to the need to inhibit/block specific PPIs. While small molecule inhibitor

Externí odkaz: https://doaj.org/article/5954f963957a435bb2f064d34f1eb4dc

Molecular docking, synthesis and biological evaluation of Vascular Endothelial Growth Factor (VEGF) B based peptide as antiangiogenic agent targeting the second domain of the Vascular Endothelial Growth Factor Receptor 1 (VEGFR1D2) for anticancer application

Autor: S. Mohsen Asghari, Saeed Balalaie, Matthew Groves, Kamran Mansouri, Afsaneh Sadremomtaz, Foroozan Jouyandeh, Razieh Navari, Ameena M Ali, Sylvain Broussy

Publikováno v: Signal Transduction and Targeted Therapy
Signal transduction and targeted therapy, 5(1):76
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-4 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429383a49b073a06d727047347d4dc64
https://pubmed.ncbi.nlm.nih.gov/32499505

The Pex4p-Pex22p complex from Hansenula polymorpha: biophysical analysis, crystallization and X-ray diffraction characterization

Autor: Matthew Groves, Sun Rei Yan, Ameena M Ali, Niels van Oosterwijk, Jack Atmaj, Sergey Lunev, Alaa Adawy, Chris Williams

Publikováno v: Acta Crystallographica Section F: Structural Biology Communications, 74(Pt 2):ISSN 2053-230X, 76-81. INT UNION CRYSTALLOGRAPHY

Peroxisomes are a major cellular compartment of eukaryotic cells, and are involved in a variety of metabolic functions and pathways according to species, cell type and environmental conditions. Their biogenesis relies on conserved genes known asPEXge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fd3b4706a6be22c511c82156cb3388
https://research.rug.nl/en/publications/d742ed22-da09-4d26-8dcd-5874380562e4

Identification and Structural Analysis of Natural Product Inhibitors of Human Alpha-Amylase to Target Diabetes Mellitus

Autor: Ameena M Ali

Publikováno v: Qatar Foundation Annual Research Conference Proceedings Volume 2016 Issue 1.

Introduction: Noninsulin dependent diabetes mellitus (NIDDM) or Diabetes Type 2 is a major health challenge worldwide. In 2014 the World Health Organization (WHO) revealed that the percentage of adults with fasting glucose ≥ 7.0 mmol/L accounts for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14fec2407b6396b099f743f2eb6bfe91
https://doi.org/10.5339/qfarc.2016.hbsp2494

Multicomponent Peptide Stapling as a Diversity‐Driven Tool for the Development of Inhibitors of Protein–Protein Interactions.

Autor: Ricardo, Manuel G.¹ (AUTHOR), Ali, Ameena M.² (AUTHOR), Plewka, Jacek³ (AUTHOR), Surmiak, Ewa³ (AUTHOR), Labuzek, Beata³ (AUTHOR), Neochoritis, Constantinos G.^2,4 (AUTHOR), Atmaj, Jack^2,3 (AUTHOR), Skalniak, Lukasz³ (AUTHOR), Zhang, Ran² (AUTHOR), Holak, Tad A.³ (AUTHOR), Groves, Matthew² (AUTHOR), Rivera, Daniel G.¹ (AUTHOR) dgr@fq.uh.cu, Dömling, Alexander² (AUTHOR) a.s.s.domling@rug.nl

Publikováno v: Angewandte Chemie. 3/23/2020, Vol. 132 Issue 13, p5273-5279. 7p.