Transiently boosting Vγ9+Vδ2+ γδ T cells early in Mtb coinfection of SIV-infected juvenile macaques does not improve Mtb host resistance.

Autor: Larson EC; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Ellis AL; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Rodgers MA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Gubernat AK; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Gleim JL; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Moriarty RV; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Balgeman AJ; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., de Menezes YT; Department of Immunobiology, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil., Ameel CL; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Fillmore DJ; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Pergalske SM; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Juno JA; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Maiello P; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Chishti HB; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Lin PL; Department of Pediatrics, UPMC's Children's Hospital of the University of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA., Godfrey DI; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Kent SJ; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.; Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Hospital and Centre Clinical School, Monash University, Melbourne, Victoria, Australia., Pellicci DG; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia., Ndhlovu LC; Department of Medicine, Division of Infectious Disease, Weill Cornell Medicine, New York, New York, USA., O'Connor SL; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Scanga CA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Publikováno v: Infection and immunity [Infect Immun] 2024 Oct 30, pp. e0031324. Date of Electronic Publication: 2024 Oct 30.

Intravenous BCG induces a more potent airway and lung immune response than intradermal BCG in SIV-infected macaques.

Autor: Jauro S; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Larson EC; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Gleim JL; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Wahlberg BM; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Rodgers MA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Chehab JC; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Lopez-Velazques AE; Department of Biology, University of Puerto Rico - Humacao Campus, Puerto Rico, USA., Ameel CL; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Tomko JA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Sakal JL; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., DeMarco T; Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Borish HJ; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Maiello P; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Potter EL; Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Lin PL; Center for Vaccine Research, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.; Department of Pediatrics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Flynn JL; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Scanga CA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 22. Date of Electronic Publication: 2024 Jul 22.

CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques.

Autor: Simonson AW; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Zeppa JJ; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Bucsan AN; Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH); Bethesda, MD, USA., Chao MC; Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health; Boston, MA, USA., Pokkali S; Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH); Bethesda, MD, USA., Hopkins F; Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health; Boston, MA, USA., Chase MR; Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health; Boston, MA, USA., Vickers AJ; Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health; Boston, MA, USA., Sutton MS; Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH); Bethesda, MD, USA., Winchell CG; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Myers AJ; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Ameel CL; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Kelly R; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Krouse B; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Hood LE; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Li J; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Lehman CC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH); Bethesda, MD, USA., Kamath M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH); Bethesda, MD, USA., Tomko J; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Rodgers MA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Donlan R; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Chishti H; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Jacob Borish H; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Klein E; Division of Animal Laboratory Resources, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Scanga CA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Fortune S; Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health; Boston, MA, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, USA., Lin PL; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Department of Pediatrics, Children's Hospital of the University of Pittsburgh of UPMC; Pittsburgh, PA, USA., Maiello P; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA., Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH); Bethesda, MD, USA., Darrah PA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH); Bethesda, MD, USA., Seder RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH); Bethesda, MD, USA., Flynn JL; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh School of Medicine; Pittsburgh, PA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 17. Date of Electronic Publication: 2024 May 17.

Intravenous Bacille Calmette-Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis.

Autor: Larson EC; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. erl72@pitt.edu.; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. erl72@pitt.edu., Ellis-Connell AL; Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA., Rodgers MA; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Gubernat AK; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Gleim JL; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Moriarty RV; Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA., Balgeman AJ; Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA., Ameel CL; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Jauro S; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Tomko JA; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Kracinovsky KB; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Maiello P; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Borish HJ; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., White AG; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Klein E; Division of Laboratory Animal Resources, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Bucsan AN; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Darrah PA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Seder RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Lin PL; Department of Pediatrics, Children's Hospital of Pittsburgh, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Flynn JL; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., O'Connor SL; Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, USA.; Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA., Scanga CA; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Publikováno v: Nature microbiology [Nat Microbiol] 2023 Nov; Vol. 8 (11), pp. 2080-2092. Date of Electronic Publication: 2023 Oct 09.

Vaccination with intravenous BCG protects macaques with pre-existing SIV infection from tuberculosis.

Autor: Larson EC; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Ellis-Connell AL; Department of Pathology and Laboratory Medicine, University of Wisconsin - Madison, Madison, WI, USA., Rodgers MA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Gubernat AK; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Gleim JL; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Moriarty RV; Department of Pathology and Laboratory Medicine, University of Wisconsin - Madison, Madison, WI, USA., Balgeman AJ; Department of Pathology and Laboratory Medicine, University of Wisconsin - Madison, Madison, WI, USA., Ameel CL; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Jauro S; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Tomko JA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Kracinovsky KB; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Maiello P; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Borish HJ; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., White AG; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Klein E; Division of Laboratory Animal Resources, School of Medicine, University of Pittsburgh, PA, USA., Bucsan AN; Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Darrah PA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Seder RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Lin PL; Department of Pediatrics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Flynn JL; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., O'Connor SL; Department of Pathology and Laboratory Medicine, University of Wisconsin - Madison, Madison, WI, USA.; Wisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, USA., Scanga CA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.; Center for Vaccine Research, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.

Publikováno v: Research square [Res Sq] 2023 Apr 17. Date of Electronic Publication: 2023 Apr 17.