Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Amedeo Columbano"'
Autor:
Andrea Caddeo, Marina Serra, Francesca Sedda, Andrea Bacci, Clementina Manera, Simona Rapposelli, Amedeo Columbano, Andrea Perra, Marta Anna Kowalik
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionSeveral lines of evidence suggest that the thyroid hormone signaling pathway is altered in patients with NAFLD and that pharmacological strategies to target the thyroid hormone/thyroid hormone nuclear receptor axis (TH/THR) in the liver m
Externí odkaz:
https://doaj.org/article/12be0e61ed8d46dc99ce7eb38fd5f8db
Autor:
Sandra Mattu, Patrizia Zavattari, Marta Anna Kowalik, Marina Serra, Pia Sulas, Rajesh Pal, Elisabetta Puliga, Salvatore Sutti, Beatrice Foglia, Maurizio Parola, Emanuele Albano, Silvia Giordano, Andrea Perra, Amedeo Columbano
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 113-127 (2022)
Background & Aims: Activation of the kelch-like ECH-associated protein 1 (Keap1)–nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway has been associated with metabolic reprogramming in many tumors, including hepatocellular carcinoma (HCC). H
Externí odkaz:
https://doaj.org/article/a287ac6f649144fb9e8b07c7fac86783
Autor:
Marina Serra, Rajesh Pal, Elisabetta Puliga, Pia Sulas, Lavinia Cabras, Roberto Cusano, Silvia Giordano, Andrea Perra, Amedeo Columbano, Marta Anna Kowalik
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundThyroid hormones (THs) inhibit hepatocellular carcinoma (HCC) through different mechanisms. However, whether microRNAs play a role in the antitumorigenic effect of THs remains unknown.MethodsBy next generation sequencing (NGS) we performed
Externí odkaz:
https://doaj.org/article/bbffdef2743543e5beb3d9ac9353c2c6
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Metal ions, such as selenium, copper, zinc, and iron are naturally present in the environment (air, drinking water, and food) and are vital for cellular functions at chemical, molecular, and biological levels. These trace elements are involved in var
Externí odkaz:
https://doaj.org/article/747ad4d1609e41b6acf85f8db9e70baa
Autor:
Andrea Caddeo, Marta Anna Kowalik, Marina Serra, Massimiliano Runfola, Andrea Bacci, Simona Rapposelli, Amedeo Columbano, Andrea Perra
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 13105 (2021)
Activation of thyroid hormone receptor β (THRβ) has shown beneficial effects on metabolic alterations, including non-alcoholic fatty liver disease (NAFLD). Here, we investigated the effect of TG68, a novel THRβ agonist, on fatty liver accumulation
Externí odkaz:
https://doaj.org/article/eb6489db7bb94974969b4f11cd0d7f94
Publikováno v:
Cancers, Vol 12, Iss 11, p 3318 (2020)
Hepatocellular carcinoma (HCC) is one the most frequent and lethal human cancers. At present, no effective treatment for advanced HCC exist; therefore, the overall prognosis for HCC patients remains dismal. In recent years, a better knowledge of the
Externí odkaz:
https://doaj.org/article/3e5413643c7d48c59142022404f6957a
Publikováno v:
Cancers, Vol 12, Iss 10, p 2932 (2020)
Activation of the Keap1/Nrf2 pathway, the most important cell defense signal, triggered to neutralize the harmful effects of electrophilic and oxidative stress, plays a crucial role in cell survival. Therefore, its ability to attenuate acute and chro
Externí odkaz:
https://doaj.org/article/feac5123c6ca4d2fb10f26bc55fdd91e
Autor:
Claudia Orrù, Andrea Perra, Marta Anna Kowalik, Sabrina Rizzolio, Elisabetta Puliga, Lavinia Cabras, Silvia Giordano, Amedeo Columbano
Publikováno v:
Cancers, Vol 12, Iss 8, p 2305 (2020)
Activation of the Nrf2-Keap1 pathway, the main intracellular defense against environmental stress, has been observed in several human cancers, including hepatocellular carcinoma (HCC). Here, we assessed whether distinct mechanisms of activation may b
Externí odkaz:
https://doaj.org/article/208217d96ff946aca607bb46347481de
Autor:
Cristina Migliore, Elena Morando, Elena Ghiso, Sergio Anastasi, Vera P Leoni, Maria Apicella, Davide Cora', Anna Sapino, Filippo Pietrantonio, Filippo De Braud, Amedeo Columbano, Oreste Segatto, Silvia Giordano
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 9, Pp n/a-n/a (2018)
Abstract The onset of secondary resistance represents a major limitation to long‐term efficacy of target therapies in cancer patients. Thus, the identification of mechanisms mediating secondary resistance is the key to the rational design of therap
Externí odkaz:
https://doaj.org/article/f09ddfa6e2014b34a62b8a6110de7ae3
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
The signaling pathways activated by thyroid hormone receptors (THR) are of fundamental importance for organogenesis, growth and differentiation, and significantly influence energy metabolism, lipid utilization and glucose homeostasis. Pharmacological
Externí odkaz:
https://doaj.org/article/e5d4850de8214d59a1adf829665cf192