Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Amechand Boodhoo"'
Autor:
John E. Hale, David M. Holtzman, Robert A. Dean, Valentina Gelfanova, Martin R. Farlow, Deborah I. Fisher, Richard E. Higgs, Karen Cox, Eric Siemers, Zhaoyan Jin, Yue Wei Qian, Xiaohua He, Amechand Boodhoo
Publikováno v:
Briefings in Functional Genomics and Proteomics. 6:149-158
Immunoprecipitation (IP) combined with matrix-assisted laser desorption ionization (MALDI) time of flight (Tof) mass spectrometry has been used to develop quantitative assays for amyloid-beta (Abeta) peptides in cerebrospinal fluid (CSF). Inclusion o
Autor:
Robert J. Konrad, Peter J. O'Brien, Michael D. Knierman, Albert E. Schultze, William E. Alborn, John H. Sloan, Maverick Ulmer, Amechand Boodhoo
Publikováno v:
Clinical Chemistry. 51:351-359
Background: The recently discovered apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately fourfold increase in serum triglycerides, wherea
Publikováno v:
Biochemistry. 43:11403-11416
The first three-dimensional structure of phenylalanine ammonia lyase (PAL) has been determined at 2.1 A resolution for PAL from Rhodosporidium toruloides. The enzyme is structurally similar to the mechanistically related histidine ammonia lyase (HAL)
Autor:
James L. Brunton, Randy J. Read, Hong Ling, Clifford G Clark, Glen D. Armstrong, Navraj S. Pannu, Amechand Boodhoo
Publikováno v:
Structure. 8:253-264
Background: Shiga-like toxins (SLTs) are produced by the pathogenic strains of Escherichia coli that cause hemorrhagic colitis and hemolytic uremic syndrome. These diseases in humans are generally associated with group II family members (SLT-II and S
Autor:
Francis X. Sullivan, Ronald W. Kriz, Mark Stahl, Amechand Boodhoo, Dale A. Cumming, Guang-Yi Xu, Barry Potvin, Jason C. Rouse, Ravindra Kumar, Xiao-Jia Chang
Publikováno v:
Journal of Biological Chemistry. 273:8193-8202
We have cloned the cDNA encoding human GDP-mannose 4,6-dehydratase, the first enzyme in the pathway converting GDP-mannose to GDP-fucose. The message is expressed in all tissues and cell lines examined, and the cDNA complements Lec13, a Chinese Hamst
Autor:
Hong Ling, Maxwell D. Cummings, Amechand Boodhoo, Randy J. Read, Glen D. Armstrong, James L. Brunton, Bart Hazes
Publikováno v:
Biochemistry. 37:1777-1788
Shiga-like toxin I (SLT-I) is a virulence factor of Escherichia coli strains that cause disease in humans. Like other members of the Shiga toxin family, it consists of an enzymatic (A) subunit and five copies of a binding subunit (the B-pentamer). Th
Autor:
Robert M. Amos, Yong Wang, Peter Stanley Borromeo, Robert J. Barr, Timothy Ivo Richardson, Gregory L. Durst, Jeffrey Alan Dodge, Harold E. Osborne, Bryan H. Norman, Scott Alan Jones, Chahrzad Montrose-Rafizadeh, and Amechand Boodhoo, Keyue Chen, Sherry Guo, Charles Willis Lugar, Venkatesh Krishnan
Publikováno v:
Journal of Medicinal Chemistry. 49:6155-6157
Benzopyran selective estrogen receptor beta agonist-1 (SERBA-1) shows potent, selective binding and agonist function in estrogen receptor beta (ERbeta) in vitro assays. X-ray crystal structures of SERBA-1 in ERalpha and beta help explain observed bet
Autor:
Amechand Boodhoo, Randy J. Read, Norma E.C. Duke, Mabel W.L. Ritzel, Dennis Kunimoto, Dequan Kong
Publikováno v:
Journal of Molecular Biology. 241:269-272
Wild-type and mutant forms of murine interleukin-5 (mIL-5) have been expressed in the baculovirus expression system, purified, and used in crystallization trials. Attempts to obtain diffraction quality crystals of wild-type protein were unsuccessful.
Publikováno v:
Journal of Molecular Biology. 221:729-731
The B-subunit of verotoxin-1, which is believed to form a pentamer (monomer Mr = 7691), has been crystallized by vapor diffusion over a wide range of conditions. The best crystals, obtained with polyethylene glycol 8000 as the precipitant, belong to
Publikováno v:
Journal of molecular biology. 258(4)
Pertussis toxin is a major virulence factor of Bordetella pertussis, the causative agent of whooping cough. The protein is a hexamer containing a catalytic subunit (S1) that is tightly associated with a pentameric cell-binding component (B-oligomer).