Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.

Autor: Ridnour LA; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Heinz WF; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Cheng RYS; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Wink AL; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Kedei N; Collaborative Protein Technology Resource (CPTR) Nanoscale Protein Analysis, Office of Science and Technology Resources, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Pore M; Imaging Mass Cytometry, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Imtiaz F; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Femino EL; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Gonzalez AL; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Coutinho LL; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland.; Center for Translational Research in Oncology, ICESP/HC, Faculdade de Medicina da Universidade de São Paulo and Comprehensive Center for Precision Oncology, Universidade de São Paulo, São Paulo, Brazil., Moffat RL; Optical Microscopy and Analysis Laboratory, Office of Science and Technology Resources, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Butcher D; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland., Edmondson EF; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland., Li X; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia., Rangel MC; Center for Translational Research in Oncology, ICESP/HC, Faculdade de Medicina da Universidade de São Paulo and Comprehensive Center for Precision Oncology, Universidade de São Paulo, São Paulo, Brazil., Kinders RJ; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Rittscher J; Institute of Biomedical Engineering, Big Data Institute, Ludwig Oxford Branch, University of Oxford, Oxford, United Kingdom., Lipkowitz S; Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Wong STC; Houston Methodist Neal Cancer Center, Weill Cornell Medical College, Houston Methodist Hospital, Houston, Texas., Anderson SK; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland.; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., McVicar DW; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Glynn SA; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, University of Galway, Galway, Ireland., Billiar TR; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania., Chang JC; Houston Methodist Neal Cancer Center, Weill Cornell Medical College, Houston Methodist Hospital, Houston, Texas., Hewitt SM; Laboratory of Pathology Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Ambs S; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Lockett SJ; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Wink DA; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland.

Publikováno v: Cancer research communications [Cancer Res Commun] 2024 Oct 01; Vol. 4 (10), pp. 2766-2782.

MIF/NR3C2 axis regulates glucose metabolism reprogramming in pancreatic cancer through MAPK-ERK and AP-1 pathways.

Autor: Yang S; Pancreatic Cancer Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Tang W; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Azizian A; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Gaedcke J; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Ohara Y; Pancreatic Cancer Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Cawley H; Pancreatic Cancer Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Hanna N; Division of Surgical Oncology, University of Maryland School of Medicine, Baltimore, MD, USA., Ghadimi M; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Lal T; Howard University College of Medicine, Washington, DC, USA., Sen S; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Creighton CJ; Dan L. Duncan Comprehensive Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX, USA., Gao J; Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Putluri N; Department of Molecular and Cellular Biology, Dan L. Duncan Comprehensive Cancer Center, Advanced Technology Core, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, TX, USA., Ambs S; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Hussain P; Pancreatic Cancer Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Publikováno v: Carcinogenesis [Carcinogenesis] 2024 Aug 12; Vol. 45 (8), pp. 582-594.

Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk for Breast Cancer.

Autor: Sun X; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Epidemiology, Zhejiang Chinese Medical University, Hangzhou, China., Verma SP; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Jia G; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee., Wang X; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Ping J; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee., Guo X; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee., Chen J; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Derkach A; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Cai Q; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee., Liang X; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Long J; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee., Offit K; Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Medicine, Weill Cornell Medical College, New York, New York., Oh JH; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York., Reiner AS; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Watt GP; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Woods M; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Yang Y; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia.; UVA Comprehensive Cancer Center, University of Virginia, Charlottesville, Virginia., Ambrosone CB; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Ambs S; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Chen Y; Department of Population Health, New York University Grossman School of Medicine, New York, New York., Concannon P; Department of Pathology, Immunology and Laboratory Medicine, Genetics Institute, University of Florida, Gainesville, Florida., Garcia-Closas M; Trans-Divisional Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland., Gu J; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Haiman CA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California., Hu JJ; The University of Miami School of Medicine, Sylvester Comprehensive Cancer Center, Miami, Florida., Huo D; Department of Public Health Sciences, University of Chicago, Chicago, Illinois., John EM; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California.; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California.; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California., Knight JA; Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada., Li CI; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington., Lynch CF; Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa., Mellemkjær L; Diet, Cancer and Health, Danish Cancer Institute, Copenhagen, Denmark., Nathanson KL; Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Nemesure B; Department of Family, Population, and Preventive Medicine, Stony Brook Medicine, Stony Brook, New York., Olopade OI; Department of Medicine, University of Chicago, Chicago, Illinois., Olshan AF; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Pal T; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Palmer JR; Slone Epidemiology Center, Boston University, Boston, Massachusetts., Press MF; Department of Pathology, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, Los Angeles, California., Sanderson M; Department of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee., Sandler DP; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina., Troester MA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee., Bernstein JL; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Buas MF; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Shu X; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.

Publikováno v: Cancer research [Cancer Res] 2024 Aug 01; Vol. 84 (15), pp. 2533-2548.

Human herpesvirus 8 infection is associated with prostate cancer among IFNL4-ΔG carriers.

Autor: Jenkins FJ; Departments of Pathology and Infectious Diseases and Microbiology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA. fjenkins@pitt.edu., Minas TZ; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Tang W; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Dorsey TH; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Ambs S; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Publikováno v: Prostate cancer and prostatic diseases [Prostate Cancer Prostatic Dis] 2023 Jun; Vol. 26 (2), pp. 338-346. Date of Electronic Publication: 2022 Apr 25.

Using genome and transcriptome data from African-ancestry female participants to identify putative breast cancer susceptibility genes.

Autor: Ping J; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Jia G; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Cai Q; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Guo X; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Tao R; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Ambrosone C; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Elm & Carlton Streets, Buffalo, NY, USA., Huo D; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA., Ambs S; Laboratory of Human Carcinogenesis, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Barnard ME; Slone Epidemiology Center, Boston University, Boston, MA, USA., Chen Y; Division of Epidemiology, Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA., Garcia-Closas M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Gu J; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hu JJ; Department of Public Health Sciences, University of Miami School of Medicine, Miami, FL, USA., John EM; Departments of Epidemiology & Population Health and of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Li CI; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Nathanson K; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Basser Center for BRCA, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Nemesure B; Department of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA., Olopade OI; Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, IL, USA., Pal T; Division of Genetic Medicine, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Press MF; Department of Pathology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA., Sanderson M; Department of Family and Community Medicine, Meharry Medical College, Nashville, TN, USA., Sandler DP; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Yoshimatsu T; Department of Public Health Sciences, The University of Chicago, Chicago, IL, USA., Adejumo PO; Department of Nursing, College of Medicine, University of Ibadan, Ibadan, Nigeria., Ahearn T; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Brewster AM; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hennis AJM; George Alleyne Chronic Disease Research Centre, University of the West Indies, Bridgetown, Barbados.; Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA., Makumbi T; Department of Surgery, Mulago Hospital, Kampala, Uganda., Ndom P; Yaounde General Hospital, Yaounde, Cameroon., O'Brien KM; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Olshan AF; Department of Epidemiology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Oluwasanu MM; Department of Health Promotion and Education, College of Medicine, University of Ibadan, Ibadan, Nigeria., Reid S; Division of Hematology and Oncology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Yao S; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Elm & Carlton Streets, Buffalo, NY, USA., Butler EN; Department of Epidemiology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Huang M; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ntekim A; Department of Radiation Oncology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Li B; Department of Molecular Physiology & Biophysics, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA., Troester MA; Department of Epidemiology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Palmer JR; Slone Epidemiology Center, Boston University, Boston, MA, USA., Haiman CA; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Long J; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA. wei.zheng@vanderbilt.edu.

Publikováno v: Nature communications [Nat Commun] 2024 May 02; Vol. 15 (1), pp. 3718. Date of Electronic Publication: 2024 May 02.