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Whole exome-seq and RNA-seq data reveal unique neoantigen profiles in Kenyan breast cancer patients

Autor: Godfrey Wagutu, John Gitau, Kennedy Mwangi, Mary Murithi, Elias Melly, Alexandra R. Harris, Shahin Sayed, Stefan Ambs, Francis Makokha

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

BackgroundThe immune response against tumors relies on distinguishing between self and non-self, the basis of cancer immunotherapy. Neoantigens from somatic mutations are central to many immunotherapeutic strategies and understanding their landscape

Externí odkaz: https://doaj.org/article/e10c13d1c1a4429d876119692daf217c

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Using genome and transcriptome data from African-ancestry female participants to identify putative breast cancer susceptibility genes

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)

Abstract African-ancestry (AA) participants are underrepresented in genetics research. Here, we conducted a transcriptome-wide association study (TWAS) in AA female participants to identify putative breast cancer susceptibility genes. We built geneti

Externí odkaz: https://doaj.org/article/b9834eb3a0344dc2a7b7b629b0f35afc

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Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract The association between fatty acids and prostate cancer remains poorly explored in African-descent populations. Here, we analyze 24 circulating fatty acids in 2934 men, including 1431 prostate cancer cases and 1503 population controls from G

Externí odkaz: https://doaj.org/article/84681ad62d1b40c89393fc3917165d7f

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Akademický článek

Association of neighborhood gentrification with prostate cancer and immune markers in African American and European American men

Autor: Catherine M. Pichardo, Adaora Ezeani, Margaret S. Pichardo, Tanya Agurs‐Collins, Tiffany M. Powell‐Wiley, Brid Ryan, Tsion Zewdu Minas, Maeve Bailey‐Whyte, Wei Tang, Tiffany H. Dorsey, William Wooten, Christopher A. Loffredo, Stefan Ambs

Publikováno v: Cancer Medicine, Vol 13, Iss 1, Pp n/a-n/a (2024)

Abstract Background Prior studies showed that neighborhood deprivation increases the risk of lethal prostate cancer. However, the role of neighborhood gentrification in prostate cancer development and outcome remains poorly understood. We examined th

Externí odkaz: https://doaj.org/article/93de936fb0c243989fcdf89a6ac867ed

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Interferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcome

Publikováno v: Cell Death and Disease, Vol 14, Iss 5, Pp 1-12 (2023)

Abstract A strong correlation between NOS2 and COX2 tumor expression and poor clinical outcomes in ER breast cancer has been established. However, the mechanisms of tumor induction of these enzymes are unclear. Analysis of The Cancer Genome Atlas (TC

Externí odkaz: https://doaj.org/article/5046eefbdac54f9198343a6b6f842146

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SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer

Autor: Yuuki Ohara, Wei Tang, Huaitian Liu, Shouhui Yang, Tiffany H. Dorsey, Helen Cawley, Paloma Moreno, Raj Chari, Mary R. Guest, Azadeh Azizian, Jochen Gaedcke, Michael Ghadimi, Nader Hanna, Stefan Ambs, S. Perwez Hussain

Publikováno v: Cell Reports, Vol 42, Iss 12, Pp 113434- (2023)

Summary: Pancreatic ductal adenocarcinoma (PDAC) exhibits distinct molecular subtypes: classical/progenitor and basal-like/squamous. Our study aimed to identify genes contributing to the development of the basal-like/squamous subtype, known for its a

Externí odkaz: https://doaj.org/article/de1d8a8b6bbd4daaa1ee9af22b193d83

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Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming

Publikováno v: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-22 (2023)

Abstract Background Chemotherapy (CT) is central to the treatment of triple negative breast cancer (TNBC), but drug toxicity and resistance place strong restrictions on treatment regimes. Fasting sensitizes cancer cells to a range of chemotherapeutic

Externí odkaz: https://doaj.org/article/664873a7a747491ba70f6612076606eb

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Akademický článek

Pharmacometabolomics reveals urinary diacetylspermine as a biomarker of doxorubicin effectiveness in triple negative breast cancer

Autor: Thomas J. Velenosi, Kristopher W. Krausz, Keisuke Hamada, Tiffany H. Dorsey, Stefan Ambs, Shogo Takahashi, Frank J. Gonzalez

Publikováno v: npj Precision Oncology, Vol 6, Iss 1, Pp 1-11 (2022)

Abstract Triple-negative breast cancer (TNBC) patients receive chemotherapy treatment, including doxorubicin, due to the lack of targeted therapies. Drug resistance is a major cause of treatment failure in TNBC and therefore, there is a need to ident

Externí odkaz: https://doaj.org/article/25dda64b91734e499386bd331a57f043

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