CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism

Autor: Cho, Hyelim, Shen, Qiong, Zhang, Lydia H., Okumura, Mikiko, Kawakami, Akinori, Ambrose, Jessi, Sigoillot, Frederic, Miller, Howard R., Gleim, Scott, Cobos-Correa, Amanda, Wang, Ying, Piechon, Philippe, Roma, Guglielmo, Eggimann, Fabian, Moore, Charles, Aspesi, Peter, Jr., Mapa, Felipa A., Burks, Heather, Ross, Nathan T., Krastel, Philipp, Hild, Marc, Maimone, Thomas J., Fisher, David E., Nomura, Daniel K., Tallarico, John A., Canham, Stephen M., Jenkins, Jeremy L., Forrester, William C.

Publikováno v: In Cell Chemical Biology 21 October 2021 28(10):1407-1419

Exquisite Sensitivity to Dual BRG1/BRM ATPase Inhibitors Reveals Broad SWI/SNF Dependencies in Acute Myeloid Leukemia.

Autor: Rago F; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Rodrigues LU; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Bonney M; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Sprouffske K; Novartis Institutes for Biomedical Research, Basel, Switzerland., Kurth E; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Elliott G; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Ambrose J; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Aspesi P; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Oborski J; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Chen JT; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., McDonald ER; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Mapa FA; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Ruddy DA; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Kauffmann A; Novartis Institutes for Biomedical Research, Basel, Switzerland., Abrams T; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Bhang HC; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Jagani Z; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.

Publikováno v: Molecular cancer research : MCR [Mol Cancer Res] 2022 Mar 01; Vol. 20 (3), pp. 361-372.