Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Ambra A Grolla"'
Autor:
Mario Paolo Colombo, Joe G N Garcia, Cristina Travelli, Giorgia Colombo, Martina Aliotta, Francesca Fagiani, Natalia Fava, Rita De Sanctis, Ambra A Grolla, Nausicaa Clemente, Paola Portararo, Massimo Costanza, Fabrizio Condorelli, Sabina Sangaletti, Armando A Genazzani
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background Nicotinamide phosphoribosyltransferase (NAMPT) is a key intracellular enzyme that participates in nicotinamide adenine dinucleotide (NAD) homeostasis as well as a released cytokine (eNAMPT) that is elevated in inflammatory conditions and i
Externí odkaz:
https://doaj.org/article/c682ddf856af461abc7e0fc0260b779f
Autor:
Laura Tapella, Giulia Dematteis, Marianna Moro, Beatrice Pistolato, Elisa Tonelli, Virginia Vita Vanella, Daniele Giustina, Aleida La Forgia, Elena Restelli, Elettra Barberis, Tito Cali, Marisa Brini, Salvatore Villani, Erika Del Grosso, Mariagrazia Grilli, Marcello Manfredi, Marco Corazzari, Ambra A. Grolla, Armando A. Genazzani, Dmitry Lim
Publikováno v:
Cell Death and Disease, Vol 13, Iss 10, Pp 1-16 (2022)
Abstract Deregulation of protein synthesis and ER stress/unfolded protein response (ER stress/UPR) have been reported in astrocytes. However, the relationships between protein synthesis deregulation and ER stress/UPR, as well as their role in the alt
Externí odkaz:
https://doaj.org/article/1066a2fb20314a06a672b12873373bd4
Autor:
Mirco Masi, Enrico Garattini, Marco Bolis, Daniele Di Marino, Luisa Maraccani, Elena Morelli, Ambra A. Grolla, Francesca Fagiani, Emanuela Corsini, Cristina Travelli, Stefano Govoni, Marco Racchi, Erica Buoso
Publikováno v:
Oncogenesis, Vol 9, Iss 12, Pp 1-15 (2020)
Abstract Recent data indicate that receptor for activated C kinase 1 (RACK1) is a putative prognostic marker and drug target in breast cancer (BC). High RACK1 expression is negatively associated with overall survival, as it seems to promote BC progre
Externí odkaz:
https://doaj.org/article/7445495c5de34d7c932fbb6d820d2238
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/55838ecbf2d14e1b8b2a5b03056b8b03
Autor:
Ubaldina Galli, Giorgia Colombo, Cristina Travelli, Gian Cesare Tron, Armando A. Genazzani, Ambra A. Grolla
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Nicotinamide adenine dinucleotide (NAD) is a cofactor of many enzymatic reactions as well as being a substrate for a number of NAD-consuming enzymes (e.g., PARPS, sirtuins, etc). NAD can be synthesized de novo starting from tryptophan, nicotinamide,
Externí odkaz:
https://doaj.org/article/533060d51ac24f429b4a5ccc95a3118e
Autor:
Antonio Sica, Armando A. Genazzani, Mario P. Colombo, Claudio Tripodo, Vincenzo Bronte, Stefano Ugel, Rosalinda Trovato, Massimiliano Mazzone, Tiziana Pressiani, Lorenza Rimassa, Paola Portararo, Gian Cesare Tron, Ubaldina Galli, Ambra A. Grolla, Sara Morlacchi, Mariangela Storto, Sabina Sangaletti, Francesca Maria Consonni, Cristina Travelli
Cancer induces alteration of hematopoiesis to fuel disease progression. We report that in tumor-bearing mice the macrophage colony-stimulating factor elevates the myeloid cell levels of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limitin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87b8ab8c814b72bcf9692fb74e41a5c1
https://doi.org/10.1158/0008-5472.c.6511605.v1
https://doi.org/10.1158/0008-5472.c.6511605.v1
Autor:
Antonio Sica, Armando A. Genazzani, Mario P. Colombo, Claudio Tripodo, Vincenzo Bronte, Stefano Ugel, Rosalinda Trovato, Massimiliano Mazzone, Tiziana Pressiani, Lorenza Rimassa, Paola Portararo, Gian Cesare Tron, Ubaldina Galli, Ambra A. Grolla, Sara Morlacchi, Mariangela Storto, Sabina Sangaletti, Francesca Maria Consonni, Cristina Travelli
NAMPT inhibitors reduce both tumor growth and MDSCs expansion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b1e81fc9844fc5d387212b7fbd130e
https://doi.org/10.1158/0008-5472.22423914
https://doi.org/10.1158/0008-5472.22423914
Autor:
Antonio Sica, Armando A. Genazzani, Mario P. Colombo, Claudio Tripodo, Vincenzo Bronte, Stefano Ugel, Rosalinda Trovato, Massimiliano Mazzone, Tiziana Pressiani, Lorenza Rimassa, Paola Portararo, Gian Cesare Tron, Ubaldina Galli, Ambra A. Grolla, Sara Morlacchi, Mariangela Storto, Sabina Sangaletti, Francesca Maria Consonni, Cristina Travelli
Supplementary methods and list of materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261dc8cac500d51bd00b4b5a81c2d4e0
https://doi.org/10.1158/0008-5472.22423893
https://doi.org/10.1158/0008-5472.22423893
Autor:
Simone Torretta, Giorgia Colombo, Cristina Travelli, Sara Boumya, Dmitry Lim, Armando A. Genazzani, Ambra A. Grolla
Publikováno v:
Cells, Vol 9, Iss 2, p 496 (2020)
(1) Background: Extracellular nicotinamide phosphoribosyltrasferase (eNAMPT) is released by various cell types with pro-tumoral and pro-inflammatory properties. In cancer, eNAMPT regulates tumor growth through the activation of intracellular pathways
Externí odkaz:
https://doaj.org/article/a70cf04abcac42aa838f7ea2da4640bd
Autor:
Arash Foroutan, Marco Corazzari, Ambra A. Grolla, Giorgia Colombo, Cristina Travelli, Armando A. Genazzani, Sewan Theeramunkong, Ubaldina Galli, Gian Cesare Tron
Publikováno v:
European journal of medicinal chemistry. 245(Pt 1)
Despite novel biological targets emerging at an impressive rate for anticancer therapy, antitubulin drugs remain the backbone of numerous oncological protocols and their efficacy has been demonstrated in a wide variety of adult and pediatric cancers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a376e4099587cd0d5b66fcded2830aac
https://pubmed.ncbi.nlm.nih.gov/36370553
https://pubmed.ncbi.nlm.nih.gov/36370553