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Microglial inclusions and neurofilament light chain release follow neuronal $\alpha$-synuclein lesions in long-term brain slice cultures

Autor: Barth, Melanie, Bacioglu, Mehtap, Schwarz, Niklas, Novotny, Renata, Brandes, Janine, Welzer, Marc, Mazzitelli, Sonia, Häsler, Lisa, Schweighauser, Manuel, Wuttke, Thomas, Kronenberg-Versteeg, Deborah, Fog, Karina, Ambjørn, Malene, Alik, Ania, Melki, Ronald, Kahle, Philipp, Shimshek, Derya, Koch, Henner, Jucker, Mathias, Tanriöver, Gaye

Publikováno v: Molecular Neurodegeneration
Molecular Neurodegeneration, BioMed Central, 2021, 16, pp.54. ⟨10.1186/s13024-021-00471-2⟩
Molecular Neurodegeneration, 2021, 16, pp.54. ⟨10.1186/s13024-021-00471-2⟩

International audience; Background: Proteopathic brain lesions are a hallmark of many age-related neurodegenerative diseases including synucleinopathies and develop at least a decade before the onset of clinical symptoms. Thus, understanding of the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0038fd538719cfb6c27579a2ab2f0ab5
https://hal-cea.archives-ouvertes.fr/cea-03344476

Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures

Autor: Barth, Melanie, Bacioglu, Mehtap, Kronenberg-Versteeg, Deborah, Fog, Karina, Ambjørn, Malene, Alik, Ania, Melki, Ronald, Kahle, Philipp J., Shimshek, Derya R., Koch, Henner, Jucker, Mathias, Tanriöver, Gaye, Schwarz, Niklas, Novotny, Renata, Brandes, Janine, Welzer, Marc, Mazzitelli, Sonia, Häsler, Lisa M., Schweighauser, Manuel, Wuttke, Thomas V.

Publikováno v: Molecular Neurodegeneration
Molecular neurodegeneration 16(1), 54 (2021). doi:10.1186/s13024-021-00471-2
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-17 (2021)

Molecular neurodegeneration 16(1), 54 (2021). doi:10.1186/s13024-021-00471-2
Published by Biomed Central, London

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea89e60b63cd58edd63ff3313c422d8
https://pubmed.ncbi.nlm.nih.gov/34380535

Additional file 1 of Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures

Autor: Barth, Melanie, Bacioglu, Mehtap, Schwarz, Niklas, Novotny, Renata, Brandes, Janine, Welzer, Marc, Mazzitelli, Sonia, Häsler, Lisa M., Schweighauser, Manuel, Wuttke, Thomas V., Kronenberg-Versteeg, Deborah, Fog, Karina, Ambjørn, Malene, Alik, Ania, Melki, Ronald, Kahle, Philipp J., Shimshek, Derya R., Koch, Henner, Jucker, Mathias, Tanriöver, Gaye

Additional file 1: Supplementary Fig. 1. αS pff characterization. (A, B) Proteolytic profiles of monomeric (A) and fibrillar (B) αS (100 M in PBS) after proteinase K treatment (3.7 μg/μl) at 37 °C. Aliquots were removed from the reaction at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8318ec74c87dfcf4b34d1a22b938ae6d

Additional file 2 of Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures

Autor: Barth, Melanie, Bacioglu, Mehtap, Schwarz, Niklas, Novotny, Renata, Brandes, Janine, Welzer, Marc, Mazzitelli, Sonia, Häsler, Lisa M., Schweighauser, Manuel, Wuttke, Thomas V., Kronenberg-Versteeg, Deborah, Fog, Karina, Ambjørn, Malene, Alik, Ania, Melki, Ronald, Kahle, Philipp J., Shimshek, Derya R., Koch, Henner, Jucker, Mathias, Tanriöver, Gaye

Additional file 2: Supplementary Fig. 2 Induction of αS aggregation is dependent on endogenous αS expression. Immunofluorescence staining for pS129 showed inclusions in Thy1-h[A53T]αS tg HSCs seeded with Thy1-h[A53T]αS tg brain homogenate. In con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3300e1aba71a66d5b312fe09c3ee7e83