Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ambikai Gajan"'
Autor:
Ambikai Gajan, Ashapurna Sarma, Seongho Kim, Katherine Gurdziel, Gen Sheng Wu, Malathy P. Shekhar
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Poly-(ADP)-ribose polymerase inhibitors (PARPi) and platinum-based drugs are promising therapies for triple negative breast cancers (TNBC) with BRCA1 or BRCA2 loss. PARPi(s) show better efficacies when combined with platinum-based therapy, however, a
Externí odkaz:
https://doaj.org/article/6e33208bd04f48508bab5d32876b0fe2
Autor:
Ambikai Gajan, Carly E. Martin, Seongho Kim, Milap Joshi, Sharon K. Michelhaugh, Ido Sloma, Sandeep Mittal, Steven Firestine, Malathy P. V. Shekhar
Publikováno v:
Cells, Vol 8, Iss 11, p 1375 (2019)
Rad6B, a principal component of the translesion synthesis pathway, and activator of canonical Wnt signaling, plays an essential role in cutaneous melanoma development and progression. As Rad6 is encoded by two genes, namely, UBE2A (RAD6A) and UBE2B (
Externí odkaz:
https://doaj.org/article/f94f9d3ec0ce41acac0a76d5dc7d19a0
Autor:
Ambikai Gajan, Katherine Gurdziel, Malathy P.V. Shekhar, Pratima Nangia-Makker, Seongho Kim, Guangzhao Mao, Ashapurna Sarma
Publikováno v:
Am J Pathol
Canonical Wnt signaling is critical for melanocyte lineage commitment and melanoma development. RAD6B, a ubiquitin-conjugating enzyme critical for translesion DNA synthesis, potentiates β-catenin stability/activity by inducing proteasome-insensitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74acf8c707383654a32781417bf8f4c
https://doi.org/10.1016/j.ajpath.2020.10.015
https://doi.org/10.1016/j.ajpath.2020.10.015
Publikováno v:
Oncotarget
// Xun Yuan 1, 2 , Dhonghyo Kho 2 , Jing Xu 2 , Ambikai Gajan 2 , Kongming Wu 1 , Gen Sheng Wu 2 1 Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P.R. China 2 Departmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2991f544496e8ab9b424f6c31b6ef753
https://doi.org/10.18632/oncotarget.15451
https://doi.org/10.18632/oncotarget.15451
Autor:
Seongho Kim, Carly E. Martin, Ambikai Gajan, Malathy P.V. Shekhar, Sandeep Mittal, Steven M. Firestine, Milap Joshi, Ido Sloma, Sharon K. Michelhaugh
Publikováno v:
Cells, Vol 8, Iss 11, p 1375 (2019)
Cells
Volume 8
Issue 11
Cells
Volume 8
Issue 11
Rad6B, a principal component of the translesion synthesis pathway, and activator of canonical Wnt signaling, plays an essential role in cutaneous melanoma development and progression. As Rad6 is encoded by two genes, namely, UBE2A (RAD6A) and UBE2B (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d863bfe2b290db1198af2743449f137b
https://www.mdpi.com/2073-4409/8/11/1375
https://www.mdpi.com/2073-4409/8/11/1375
Publikováno v:
J Biol Chem
The SIN3 histone-modifying complex regulates the expression of multiple methionine catabolic genes, including SAM synthetase (Sam-S), as well as SAM levels. To further dissect the relationship between methionine catabolism and epigenetic regulation b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae2ae5e879cf8b45316d0156f9687dd
https://pubmed.ncbi.nlm.nih.gov/31776190
https://pubmed.ncbi.nlm.nih.gov/31776190
Publikováno v:
Biochim Biophys Acta Mol Basis Dis
Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype with few therapy options besides chemotherapy. Although platinum-based drugs have shown initial activity in BRCA1-mutated TNBCs, chemoresistance remains a challenge. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364a9c62e9aedfe459c20f3368a09b6b
https://pubmed.ncbi.nlm.nih.gov/31639439
https://pubmed.ncbi.nlm.nih.gov/31639439
Publikováno v:
Cancer metastasis reviews. 37(4)
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of the TRAIL pathway in inducing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f331725ad0a2bdbdb872daffb98e73
https://pubmed.ncbi.nlm.nih.gov/29541897
https://pubmed.ncbi.nlm.nih.gov/29541897
Publikováno v:
BMC Genomics
Background The multisubunit SIN3 complex is a global transcriptional regulator. In Drosophila, a single Sin3A gene encodes different isoforms of SIN3, of which SIN3 187 and SIN3 220 are the major isoforms. Previous studies have demonstrated functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f917c7821fdb77d3727d7ff9c0bbd4
https://doi.org/10.1186/s12864-016-2428-5
https://doi.org/10.1186/s12864-016-2428-5
Scatter plots representing the correlation between replicates of RNA-seq experiment. This figure is related to Figs. 4, 5 and 6 (PDF 9866 kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d38b5eb84b008719e3515e97d526f70
