Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Amber Wilkerson"'
Autor:
Céline Portal, Yvonne Lin, Varuni Rastogi, Cornelia Peterson, Samuel Chi-Hung Yiu, James W. Foster, Amber Wilkerson, Igor A. Butovich, Carlo Iomini
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Meibomian gland (MG) cells are ciliated in early stages of development and primary cilium is required to regulate early MG cell patterning within developing glands, with cilia-mediated signaling pathways identified as therapeutic targets.
Externí odkaz:
https://doaj.org/article/1c246975864b4059b4eaf087504751f5
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13512 (2023)
The main function of exocrine Meibomian glands (MGs) is to produce a lipid-rich secretion called meibum which plays a critical role in maintaining the ocular surface homeostasis of humans and most mammals. The chemical composition of meibum, and its
Externí odkaz:
https://doaj.org/article/3214e91e3c4d4677b0dfecd7eb0f0c9c
Autor:
Igor A. Butovich, Amber Wilkerson
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7884 (2022)
Meibomian glands (MGs) and their holocrine secretion—meibum—play crucial roles in the physiology of the eye, providing protection from environmental factors and desiccation, among other functions. Importantly, aging was implicated in the deterior
Externí odkaz:
https://doaj.org/article/ab09b80c418442c4938e0f2043b153d5
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1583 (2021)
Previous studies on ablation of several key genes of meibogenesis related to fatty acid elongation, omega oxidation, and esterification into wax esters have demonstrated that inactivation of any of them led to predicted changes in the meibum lipid pr
Externí odkaz:
https://doaj.org/article/f8929392f534466ca279049a220132cd
Publikováno v:
J Biol Chem
Exocrine meibomian glands (MGs) play a central role in the ocular physiology and biochemistry by producing in situ and, mostly, de novo a secretion (meibum), which is composed of a complex mixture of homologous lipids of various classes, in a metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a79f8a042ebda31cce615575c8996d4
https://europepmc.org/articles/PMC10070659/
https://europepmc.org/articles/PMC10070659/
Autor:
Céline Portal, Yvonne Lin, Varuni Rastogi, Cornelia Peterson, Samuel Yiu, James Foster, Amber Wilkerson, Igor Butovich, Carlo Iomini
Meibomian glands (MGs) are modified sebaceous glands which produce the tear film's lipid component. Despite their critical function in maintaining clear vision, the mechanisms underlying MG morphogenesis during development and disease pathogenesis re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fe5c24707fa965f10cc299f58a5d446
https://doi.org/10.21203/rs.3.rs-1930733/v1
https://doi.org/10.21203/rs.3.rs-1930733/v1
Autor:
Igor A. Butovich, Amber Wilkerson, Kelli R. Goggans, Olga V. Belyaeva, Natalia Y. Kedishvili, Seher Yuksel
Publikováno v:
Journal of Biological Chemistry. 299:104725
Autor:
Céline Portal, Yvonne Lin, Varuni Rastogi, Cornelia Peterson, James Foster, Amber Wilkerson, Igor Butovich, Carlo Iomini
PurposePrimary cilia regulate the development of various ectoderm-derived tissues, including the corneal epithelium, skin, hair follicle and sebaceous glands. We aimed to investigate their role in meibomian gland (MG) development.MethodsPrimary ciliu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::667306cfe7f590aeff05cdbf8fece452
https://doi.org/10.1101/2022.05.16.492188
https://doi.org/10.1101/2022.05.16.492188
Publikováno v:
Melanoma Res
OBJECTIVE: The objective was to determine if the absence of FasL signaling would affect melanoma liver metastases by influencing the anti-melanoma properties of liver natural killer (NK) cells. METHODS: Melanoma liver metastases were induced in wild-
Publikováno v:
FASEB J
Recently, elongase of very long chain fatty acids-3 (ELOVL3) was demonstrated to play a pivotal role in physiology and biochemistry of the ocular surface by maintaining a proper balance in the lipid composition of meibum. The goal of this study was t