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Autor:
Amber Scotton, Brian Beardslee, Khanh T. Do, Geoffrey I. Shapiro, Sheelagh Frame, Solida Pruitt-Thompson, Daniella Zheleva, Ketki Bhushan, Nicole G. Chau, David Blake, Andrew Wolanski, Judy H. Chiao, Faith Hassinger
Publikováno v:
Cancer Research. 78:CT037-CT037
Background: CYC065 is a potent and selective inhibitor of CDK2 and CDK9. CDK2 drives cell cycle transition and activates major DNA double-strand break repair pathways; CDK9 regulates transcription of genes through phosphorylation of RNAP II. This fir