Effect of osteoporosis treatment agents on the cortical bone osteocyte microenvironment in adult estrogen-deficient, osteopenic rats

Autor: Amber Rath Stern, Xiaomei Yao, Yong Wang, Amanuel Berhe, Mark Dallas, Mark L. Johnson, Wei Yao, Donald B. Kimmel, Nancy E. Lane

Publikováno v: Bone Reports, Vol 8, Iss , Pp 115-124 (2018)

Though osteoporosis is a significant cause of disability worldwide, treatment with pharmacologic agents decreases risk of fragility fracture. Though these treatments act through the bone remodeling system to improve bone mass, it is unclear if they a

Externí odkaz: https://doaj.org/article/3cd125d351134d8ba2f45f54ab52ed6f

Osteoblast-specific deletion of Pkd2 leads to low-turnover osteopenia and reduced bone marrow adiposity.

Autor: Zhousheng Xiao, Li Cao, Yingjuan Liang, Jinsong Huang, Amber Rath Stern, Mark Dallas, Mark Johnson, Leigh Darryl Quarles

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114198 (2014)

Polycystin-1 (Pkd1) interacts with polycystin-2 (Pkd2) to form an interdependent signaling complex. Selective deletion of Pkd1 in the osteoblast lineage reciprocally regulates osteoblastogenesis and adipogenesis. The role of Pkd2 in skeletal developm

Externí odkaz: https://doaj.org/article/09bc6c1ed4314e27b473d4a974dd4c8e

Isolation of Murine and Human Osteocytes

Autor: Matthew, Prideaux, Amber Rath, Stern, Lynda F, Bonewald

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2221

Osteocytes are thought to be the mechanosensors of bone by sensing mechanical loads imposed upon the bone and transmitting these signals to the other bone cells to initiate bone modeling and remodeling. The location of osteocytes deep within bone is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a63d0c2e517adf4e1d6f980330cadc7e
https://pubmed.ncbi.nlm.nih.gov/32979194

Deletion of a Single β-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading

Autor: Mark L. Johnson, Hong Zhao, Nuria Lara, Ying Liu, Amber Rath Stern, Mark Dallas, Behzad Javaheri, Lynda F. Bonewald

Publikováno v: Journal of Bone and Mineral Research. 29:705-715

The Wnt/β-catenin signaling pathway is essential for bone cell viability and function and for skeletal integrity. To determine if β-catenin in osteocytes plays a role in the bone anabolic response to mechanical loading, 18- to 24-week-old osteocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e36da968863b3cc0fa94146bf7dc1c27
https://doi.org/10.1002/jbmr.2064

Osteocyte isolation and culture methods

Autor: Astrid D. Bakker, Matt M Stern, Janak L. Pathak, Nathalie Bravenboer, Amber Rath Stern, Karan M. Shah

Publikováno v: BoneKEy reports, 5:838
BoneKEy reports, 5:838. Nature Publishing Group
Shah, K M, Stern, M M, Stern, A R, Pathak, J L, Bravenboer, N & Bakker, A D 2016, ' Osteocyte isolation and culture methods ', BoneKEy reports, vol. 5 . https://doi.org/10.1038/bonekey.2016.65
Shah, K M, Stern, M M, Stern, A R, Pathak, J L, Bravenboer, N & Bakker, A D 2016, ' Osteocyte isolation and culture methods ', BoneKEy reports, vol. 5, 838 . https://doi.org/10.1038/bonekey.2016.65
BoneKEy reports, 5

The aim of this paper is to present several popular methods for in vitro culture of osteocytes and osteocyte cell lines. Osteocytes are located extremely suitably within the calcified bone matrix to sense mechanical signals, and are equipped with a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5820d3e00bece61373431953c46bc0fb