Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Amber M. Hummel"'
Autor:
Alvise Berti, Sophie Hillion, Amber M. Hummel, Young Min Son, Nedra Chriti, Tobias Peikert, Eva M. Carmona, Wayel H. Abdulahad, Peter Heeringa, Kristina M. Harris, E. William St. Clair, Paul Brunetta, Fernando C. Fervenza, Carol A. Langford, Cees G.M. Kallenberg, Peter A. Merkel, Paul A. Monach, Philip Seo, Robert F. Spiera, John H. Stone, Guido Grandi, Jie Sun, Jacques-Olivier Pers, Ulrich Specks, Divi Cornec, for the RAVE-ITN Research Group
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
BACKGROUND Little is known about the autoreactive B cells in antineutrophil cytoplasmic antibody–associated (ANCA-associated) vasculitis (AAV). We aimed to investigate tolerance checkpoints of circulating antigen-specific proteinase 3–reactive (P
Externí odkaz:
https://doaj.org/article/17108e393aed484eae0eb4f26d7643a8
Autor:
Gwen E. Thompson, Lynn A. Fussner, Amber M. Hummel, Darrell R. Schroeder, Francisco Silva, Melissa R. Snyder, Carol A. Langford, Peter A. Merkel, Paul A. Monach, Philip Seo, Robert F. Spiera, E. William St. Clair, John H. Stone, Ulrich Specks
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Background: The utility of ANCA testing as an indicator of disease activity in ANCA-associated vasculitis (AAV) remains controversial. This study aimed to determine the association of ANCA testing by various methods and subsequent remission and exami
Externí odkaz:
https://doaj.org/article/5b2b451663a14cfb8d37666f6f1c8cbf
Autor:
Yuan-Ping Pang, Marta Casal Moura, Gwen E. Thompson, Darlene R. Nelson, Amber M. Hummel, Dieter E. Jenne, Daniel Emerling, Wayne Volkmuth, William H. Robinson, Ulrich Specks
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Mutants of a catalytically inactive variant of Proteinase 3 (PR3)—iPR3-Val103 possessing a Ser195Ala mutation relative to wild-type PR3-Val103—offer insights into how autoantigen PR3 interacts with antineutrophil cytoplasmic antibodies (ANCAs) in
Externí odkaz:
https://doaj.org/article/315a254bfbd1410fbcbda94f11de70d8
Autor:
Marta Casal, Moura, Gwen E, Thompson, Darlene R, Nelson, Lynn A, Fussner, Amber M, Hummel, Dieter E, Jenne, Daniel, Emerling, Fernando C, Fervenza, Cees G M, Kallenberg, Carol A, Langford, W Joseph, McCune, Peter A, Merkel, Paul A, Monach, Philip, Seo, Robert F, Spiera, E William, St Clair, Steven R, Ytterberg, John H, Stone, William H, Robinson, Ulrich, Specks
Publikováno v:
Arthritis & Rheumatology. 75:748-759
Proteinase 3 (PR3) is the major antigen for anti-neutrophil cytoplasmic antibodies (ANCAs) in the systemic autoimmune vasculitis, granulomatosis with polyangiitis (GPA). PR3 anti-neutrophil cytoplasmic antibodies (PR3-ANCAs) recognize different epito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217c0e0a91fc7f243c0e23863cd966ce
https://doi.org/10.1002/art.42418
https://doi.org/10.1002/art.42418
Autor:
Alvise, Berti, Sophie, Hillion, Maximilian F, Konig, Marta, Casal Moura, Amber M, Hummel, Eva, Carmona, Tobias, Peikert, Fernando C, Fervenza, Cees G M, Kallenberg, Carol A, Langford, Peter A, Merkel, Paul A, Monach, Philip, Seo, Robert F, Spiera, Paul, Brunetta, E William, St Clair, Kristina M, Harris, John H, Stone, Guido, Grandi, Jacques-Olivier, Pers, Ulrich, Specks, Divi, Cornec
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.).
Autoreactive B cells are responsible for ANCA production in ANCA-associated vasculitis (AAV). Rituximab depletes circulating B cells including autoreactive ones. We aimed to evaluate changes and associations with relapse of the circulating autoreacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::813b3edd4452c6b8c59889c8e2796c9d
https://pubmed.ncbi.nlm.nih.gov/36281741
https://pubmed.ncbi.nlm.nih.gov/36281741
Autor:
null Carla Guarino, Seda Seren, Roxane Lemoine, Amber M. Hummel, Jean-Edouard Margotin, Jamel El-Benna, Cyrille Hoarau, Ulrich Specks, Dieter E. Jenne, Brice Korkmaz
Publikováno v:
J Biol Chem
Proteinase 3 (PR3) is the main target antigen of antineutrophil cytoplasmic antibodies (ANCAs) in PR3-ANCA–associated vasculitis. A small fraction of PR3 is constitutively exposed on the surface of quiescent blood neutrophils in a proteolytically i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a814ecd37fa7795d6674531c2aa5b1
https://doi.org/10.1016/j.jbc.2023.103072
https://doi.org/10.1016/j.jbc.2023.103072
Autor:
Carol A. Langford, Paul A. Monach, Kristina M. Harris, Alvise Berti, Paul Brunetta, Robert Spiera, Jacques-Olivier Pers, Divi Cornec, E. William St. Clair, Peter Heeringa, Ulrich Specks, Philip Seo, Tobias Peikert, Sophie Hillion, Amber M. Hummel, Peter A. Merkel, Young Min Son, Nedra Chriti, Wayel H. Abdulahad, Fernando C. Fervenza, Jie Sun, Cees G. M. Kallenberg, John H. Stone, Eva M. Carmona, Guido Grandi
Publikováno v:
JCI Insight, 6(22):150999. AMER SOC CLINICAL INVESTIGATION INC
JCI Insight
JCI Insight
BACKGROUND Little is known about the autoreactive B cells in antineutrophil cytoplasmic antibody–associated (ANCA-associated) vasculitis (AAV). We aimed to investigate tolerance checkpoints of circulating antigen-specific proteinase 3–reactive (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac6ce95d3a976110d1a0de400e51e18
https://research.rug.nl/en/publications/34b3ff7d-2935-40e5-96d1-3740358d1b9f
https://research.rug.nl/en/publications/34b3ff7d-2935-40e5-96d1-3740358d1b9f
Autor:
Paul A. Monach, Robert Spiera, Paul Brunetta, Darrell R. Schroeder, Ulrich Specks, Amber M. Hummel, Matthew D Cascino, David R. Barnidge, David L. Murray, Brian Kabat, Melissa R. Snyder, Cees G. M. Kallenberg, Fernando C. Fervenza, Philip Seo, Carol A. Langford, Peter A. Merkel, E. William St. Clair, John Mills, John H. Stone, Divi Cornec, Gary S. Hoffman, Melissa Cheu
Publikováno v:
Rheumatology, 57(4), 639-650. Oxford University Press
Objectives. To study the determinants of the pharmacokinetics (PK) of rituximab (RTX) in patients with ANCA-associated vasculitis (AAV) and its association with clinical outcomes.Methods. This study included data from 89 patients from the RTX in AAV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabb05841a55ab4c7dd2370d4a20b566
https://hdl.handle.net/11370/136e67cb-36f3-48a2-80d5-d9b8938bbd38
https://hdl.handle.net/11370/136e67cb-36f3-48a2-80d5-d9b8938bbd38
Autor:
Cornelis Kallenberg, Steven R. Ytterberg, Carol A. Langford, Amber M. Hummel, Paul A. Monach, E W St Clair, Peter A. Merkel, Robert Spiera, John H. Stone, Philip Seo, Fernando C. Fervenza, Jeremy Clain, Ulrich Specks, W. J. McCune, Gary S. Hoffman
Publikováno v:
Clinical and Experimental Immunology, 188(1), 174-181. Wiley
Summary Anti-neutrophil cytoplasmic antibodies (ANCA) appear to play an important role in the pathogenesis of ANCA-associated vasculitis (AAV). However, ANCA alone are not sufficient to generate disease, and some evidence suggests that infectious tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff7ab6522ed1591ab1cdff339a84795
https://hdl.handle.net/11370/f626042f-8d71-4daf-ac78-40867f325d7e
https://hdl.handle.net/11370/f626042f-8d71-4daf-ac78-40867f325d7e
Autor:
Mariella D'Adda, Cinzia Lamorgese, Gina Gregorini, Francesca Schieppati, Erika Borlenghi, Giuseppe Rossi, Amber M. Hummel, Ulrich Specks
Publikováno v:
American Journal of Hematology. 93:E227-E229
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9c295f091637ecced8aab6896a541e4
https://doi.org/10.1002/ajh.25197
https://doi.org/10.1002/ajh.25197