Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Amber M. D'Souza"'
Autor:
Amber M. D’Souza, Ashley Cast, Meenasri Kumbaji, Maria Rivas, Ruhi Gulati, Michael Johnston, David Smithrud, James Geller, Nikolai Timchenko
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Objective: Relapsed hepatoblastoma (HBL) and upfront hepatocellular carcinoma (HCC) are notoriously chemoresistant tumors associated with poor outcomes. Gankyrin (Gank) is a known oncogene that is overexpressed in pediatric liver cancer and implicate
Externí odkaz:
https://doaj.org/article/424a732d9bf24905ba8fb8f98cded537
Autor:
Amber M. D’Souza, Yanjun Jiang, Ashley Cast, Leila Valanejad, Mary Wright, Kyle Lewis, Meenasri Kumbaji, Sheeniza Shah, David Smithrud, Rebekah Karns, Soona Shin, Nikolai Timchenko
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 3, Pp 239-255 (2018)
Background & Aims: Uncontrolled liver proliferation is a key characteristic of liver cancer; however, the mechanisms by which this occurs are not well understood. Elucidation of these mechanisms is necessary for the development of better therapy. The
Externí odkaz:
https://doaj.org/article/f914550a6269442790392ede33498bb3
Autor:
Amber M. D’Souza, Manu Gnanamony, Maria Thomas, Peter Hanley, Dipti Kanabar, Pedro de Alarcon, Aaron Muth, Nikolai Timchenko
Publikováno v:
Cancers; Volume 14; Issue 13; Pages: 3068
Background: Gankyrin, a member of the 26S proteasome, is an overexpressed oncoprotein in hepatoblastoma (HBL) and hepatocellular carcinoma (HCC). Cjoc42 was the first small molecule inhibitor of Gankyrin developed; however, the IC50 values of >50 μM
Publikováno v:
Pediatric Blood & Cancer. 68
Autor:
Katie A. Devine, Cynthia A. Gerhardt, Jennifer Reiter-Purtill, Robert B. Noll, Kathryn Vannatta, Amber M. D'Souza
Publikováno v:
Psycho-Oncology. 28:2009-2016
Objective As the number of pediatric cancer survivors increases, so does our need to understand behavioral late effects. Prior studies show mixed results, with some noting increased emotional distress and psychiatric diagnoses in cancer survivors and
Autor:
Greg Tiao, Amber M. D'Souza, Alexander J. Towbin, Maria H. Alonso, James I. Geller, Jaimie D. Nathan, Anita Gupta, Alexander Bondoc
Publikováno v:
Pediatric Blood & Cancer. 67
Background Hepatocellular carcinoma (HCC) is often a chemoresistant neoplasm with a poor prognosis. Pediatric HCC may reflect unique biological and clinical heterogeneity. Procedure An IRB-approved retrospective institutional review of patients with
Autor:
Amber M D'Souza
Publikováno v:
Pediatric annals. 49(1)
Anemia may be defined as a reduction in red blood cell mass or blood hemoglobin concentration. Physiologically, this represents a hemoglobin level that is too low to meet cellular oxygen demands. Practically, the lower limit of normal is set at 2 sta
Autor:
Yanjun Jiang, Meenasri Kumbaji, Amber M. D'Souza, Sheeniza Shah, Leila Valanejad, Ashley Cast, Rebekah Karns, Mary Wright, David B. Smithrud, Soona Shin, Kyle Lewis, Nikolai A. Timchenko
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 3, Pp 239-255 (2018)
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 3, Pp 239-255 (2018)
Background & Aims Uncontrolled liver proliferation is a key characteristic of liver cancer; however, the mechanisms by which this occurs are not well understood. Elucidation of these mechanisms is necessary for the development of better therapy. The
Autor:
Kevin E. Bove, Rachel Sheridan, Leila Valanejad, James I. Geller, David L. Nelson, Nikolai A. Timchenko, Anita Gupta, Lubov Timchenko, Mary Wright, Kyle Lewis, Yanjun Jiang, David P. Witte, Gregory M. Tiao, Rebekah Karns, Amber M. D'Souza
Publikováno v:
Carcinogenesis. 38:738-747
The development of hepatoblastoma (HBL) is associated with failure of hepatic stem cells (HSC) to differentiate into hepatocytes. Despite intensive investigations, mechanisms of the failure of HSC to differentiate are not known. We found that oncogen
Autor:
Ehab M. Abo-Ali, Manu Gnanamony, Henna Shah, Joseph Almasri, Dawn Nguyen, Amber M. D'Souza, Younos Otmankel, Mark El Menyewi, Pamela Farrales, Dipti D. Kanabar, Vikas V. Dukhande, Aaron Muth
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(4)
Gankyrin is an oncogenic protein involved in various biological processes, such as cellular growth and proliferation. Its overexpression in certain cancers results in an increase of gankyrin-mediated protein-protein interactions (PPIs), leading to ca