Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Amber M Smith"'
Autor:
Daniel Cresta, Donald C Warren, Christian Quirouette, Amanda P Smith, Lindey C Lane, Amber M Smith, Catherine A A Beauchemin
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 1, p e1010877 (2023)
[This corrects the article DOI: 10.1371/journal.pcbi.1009480.].
Externí odkaz:
https://doaj.org/article/1ea084e9857c4e4183c3d48f660b6879
Autor:
Daniel Cresta, Donald C Warren, Christian Quirouette, Amanda P Smith, Lindey C Lane, Amber M Smith, Catherine A A Beauchemin
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009480 (2021)
The endpoint dilution assay's output, the 50% infectious dose (ID50), is calculated using the Reed-Muench or Spearman-Kärber mathematical approximations, which are biased and often miscalculated. We introduce a replacement for the ID50 that we call
Externí odkaz:
https://doaj.org/article/ceaf78c8923c45f0a7ea8d8aea1bad0b
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009299 (2021)
Human parainfluenza viruses (HPIVs) are a leading cause of acute respiratory infection hospitalization in children, yet little is known about how dose, strain, tissue tropism, and individual heterogeneity affects the processes driving growth and clea
Externí odkaz:
https://doaj.org/article/d3c9ec477df046dcad760f539c2dad11
Autor:
Adrianne L Jenner, Rosemary A Aogo, Sofia Alfonso, Vivienne Crowe, Xiaoyan Deng, Amanda P Smith, Penelope A Morel, Courtney L Davis, Amber M Smith, Morgan Craig
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009753 (2021)
To understand the diversity of immune responses to SARS-CoV-2 and distinguish features that predispose individuals to severe COVID-19, we developed a mechanistic, within-host mathematical model and virtual patient cohort. Our results suggest that vir
Externí odkaz:
https://doaj.org/article/86eccbc7e2a545a8b458e4b5aad4d54d
Autor:
Margaret A Myers, Amanda P Smith, Lindey C Lane, David J Moquin, Rosemary Aogo, Stacie Woolard, Paul Thomas, Peter Vogel, Amber M Smith
Publikováno v:
eLife, Vol 10 (2021)
Influenza viruses cause a significant amount of morbidity and mortality. Understanding host immune control efficacy and how different factors influence lung injury and disease severity are critical. We established and validated dynamical connections
Externí odkaz:
https://doaj.org/article/63032c56bed7486589c6711a20b13631
Autor:
Angeline E Rodriguez, Christopher Bogart, Christopher M Gilbert, Jonathan A McCullers, Amber M Smith, Thirumala-Devi Kanneganti, Christopher R Lupfer
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212236 (2019)
Viral-bacterial coinfections, such as with influenza A virus and Streptococcus pneumoniae (S.p.), are known to cause severe pneumonia. It is well known that the host response has an important role in disease. Interleukin-1β (IL-1β) is an important
Externí odkaz:
https://doaj.org/article/dd5b7f25f6034424807b638b6ebc2cfa
Autor:
Jennifer M Binning, Amber M Smith, Judd F Hultquist, Charles S Craik, Nathalie Caretta Cartozo, Melody G Campbell, Lily Burton, Florencia La Greca, Michael J McGregor, Hai M Ta, Koen Bartholomeeusen, B Matija Peterlin, Nevan J Krogan, Natalia Sevillano, Yifan Cheng, John D Gross
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006830 (2018)
The lentiviral protein Viral Infectivity Factor (Vif) counteracts the antiviral effects of host APOBEC3 (A3) proteins and contributes to persistent HIV infection. Vif targets A3 restriction factors for ubiquitination and proteasomal degradation by re
Externí odkaz:
https://doaj.org/article/7095456598e14d2cb94a7e382671d584
Autor:
Amber M Smith, Frederick R Adler, Ruy M Ribeiro, Ryan N Gutenkunst, Julie L McAuley, Jonathan A McCullers, Alan S Perelson
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3, p e1003238 (2013)
Secondary bacterial infections are a leading cause of illness and death during epidemic and pandemic influenza. Experimental studies suggest a lethal synergism between influenza and certain bacteria, particularly Streptococcus pneumoniae, but the pre
Externí odkaz:
https://doaj.org/article/80bd0af2c13d47d994bd55b47d3c9a6a
Autor:
Luke Barron, Amber M Smith, Karim C El Kasmi, Joseph E Qualls, Xiaozhu Huang, Allen Cheever, Lee A Borthwick, Mark S Wilson, Peter J Murray, Thomas A Wynn
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61961 (2013)
Th2-driven lung inflammation increases Arginase 1 (Arg1) expression in alternatively-activated macrophages (AAMs). AAMs modulate T cell and wound healing responses and Arg1 might contribute to asthma pathogenesis by inhibiting nitric oxide production
Externí odkaz:
https://doaj.org/article/3070d76f60e94c6381d4c5f639a7299c
Autor:
Amber M Smith, Frederick R Adler, Julie L McAuley, Ryan N Gutenkunst, Ruy M Ribeiro, Jonathan A McCullers, Alan S Perelson
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 2, p e1001081 (2011)
Relatively little is known about the viral factors contributing to the lethality of the 1918 pandemic, although its unparalleled virulence was likely due in part to the newly discovered PB1-F2 protein. This protein, while unnecessary for replication,
Externí odkaz:
https://doaj.org/article/4b22962761f448a1bf1fbadf1a1cf4b9