Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Amber Lasek"'
Autor:
Mark E. Burkard, Beth A. Weaver, Sandeep Saha, Kari B. Wisinski, Josephine M. Harter, Jennifer J. Laffin, Craig Kanugh, Hyunjung Kim, Ryan A. Denu, Amber Lasek, Lauren M. Zasadil, Robert F. Lera, Brittany Zachek, Alka Choudhary
This file contains Supplementary Table 1 and provides hazard ratios for recurrence free survival and overall survival for polyploidy and clinical variables using a Cox proportional hazard model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12e9b0c0f29f0af487036bc12d17472
https://doi.org/10.1158/1535-7163.22503648
https://doi.org/10.1158/1535-7163.22503648
Autor:
Mark E. Burkard, Beth A. Weaver, Sandeep Saha, Kari B. Wisinski, Josephine M. Harter, Jennifer J. Laffin, Craig Kanugh, Hyunjung Kim, Ryan A. Denu, Amber Lasek, Lauren M. Zasadil, Robert F. Lera, Brittany Zachek, Alka Choudhary
This file contains supplementary figures S1-S4. These illustrate correlation of ploidy from chromosome 17 FSIH versus 6-chromosome FISH, chromosome spreads of cell lines, additional dose-response curves, and data demonstrating DPBQ does not operate b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776bcb0317a3033234b9b87e5ffafbed
https://doi.org/10.1158/1535-7163.22503651.v1
https://doi.org/10.1158/1535-7163.22503651.v1
Autor:
Amber Lasek, Jun Wan, Kayla Correia-Staudt, Tim S. Bugni, Kari B. Wisinski, Amber S. Zhou, Stephanie M. McGregor, Amy M. Fowler, Mark E. Burkard, Jonathan Fitzgerald, John B. Tucker, Karla Esbona, Lauren M. Zasadil, Christina M. Scribano, Amye J. Tevaarwerk, Ryan Molini, Beth A. Weaver, Ruth O'Regan, Angela M. Lager, Jennifer Laffin, Rick Chappell
Publikováno v:
Sci Transl Med
Paclitaxel (Taxol) is a cornerstone of cancer treatment. However, its mechanism of cytotoxicity is incompletely understood and not all patients benefit from treatment. We show that patients with breast cancer did not accumulate sufficient intratumora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c001273086d6d430d83a6c11b9ba2676
https://doi.org/10.1126/scitranslmed.abd4811
https://doi.org/10.1126/scitranslmed.abd4811
Autor:
Troy A. Hornberger, Emily M. Vaughan, Nicolas Vitale, William M. Bement, Jae-Sung You, Hoi-Ying Elsie Yu, Amber Lasek
Publikováno v:
Molecular Biology of the Cell
Molecular Biology of the Cell, American Society for Cell Biology, 2014, 25 (12), pp.1867-1876. ⟨10.1091/mbc.E14-03-0839⟩
Molecular Biology of the Cell, American Society for Cell Biology, 2014, 25 (12), pp.1867-1876. ⟨10.1091/mbc.E14-03-0839⟩
Cell repair is a conserved and medically important process. Cell damage triggers the rapid accumulation of several different lipids around wounds, and the lipids sort into distinct domains around them. One of these lipids—diacylglycerol—is requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91905a47d15de87dc199e28888963c2e
https://doi.org/10.1091/mbc.e14-03-0839
https://doi.org/10.1091/mbc.e14-03-0839
Publikováno v:
Cancer Research. 78:1844-1844
Paclitaxel (Taxol) is a widely utilized treatment for primary and metastatic breast cancer. However, only about 50% of patients respond and no predictive biomarker for paclitaxel efficacy is currently available. Identification of a clinically validat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::994813bc87f553219e13ff5b9db1f086
https://doi.org/10.1158/1538-7445.am2018-1844
https://doi.org/10.1158/1538-7445.am2018-1844
Autor:
Hyun-Jung Kim, Lauren M. Zasadil, Beth A. Weaver, Ryan A. Denu, Robert F. Lera, Brittany Zachek, Jennifer Laffin, Josephine Harter, Kari B. Wisinski, Amber Lasek, Mark E. Burkard, Craig Kanugh, Sandeep Saha, Alka Choudhary
Publikováno v:
Molecular cancer therapeutics. 15(1)
Increased ploidy is common in tumors but treatments for tumors with excess chromosome sets are not available. Here, we characterize high-ploidy breast cancers and identify potential anticancer compounds selective for the high-ploidy state. Among 354
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403ca1f1684cb1209adfece540ee67a3
https://pubmed.ncbi.nlm.nih.gov/26586723
https://pubmed.ncbi.nlm.nih.gov/26586723
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0150225 (2016)
PLoS ONE
PLoS ONE
Mitosis is coordinated by carefully controlled phosphorylation and ubiquitin-mediated proteolysis. Polo-like kinase 1 (Plk1) plays a central role in regulating mitosis and cytokinesis by phosphorylating target proteins. Yet, Plk1 is itself a target f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8dc8f5943b49f852e9c325eaaa01e3
https://doi.org/10.1371/journal.pone.0150225
https://doi.org/10.1371/journal.pone.0150225