Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Amber L, Mosley"'
Autor:
Pablo Martinez, Henika Patel, Yanwen You, Emma H. Doud, Amber L. Mosley, Cristian A. Lasagna-Reeves
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103185- (2024)
Summary: The aggregation and spreading of “tau-seeds” are key for the development and progression of tauopathies, including Alzheimer’s disease. Here we describe the steps to isolate and analyze biochemically active tau-seeds from human, mouse,
Externí odkaz:
https://doaj.org/article/9aab8bca630c4876a186cab5b1948ee3
Autor:
Brittnie-lee M. Duffus, David L. Haggerty, Emma H. Doud, Amber L. Mosley, Bryan K. Yamamoto, Brady K. Atwood
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Alcohol misuse is the third leading preventable cause of death in the world. The World Health Organization currently estimates that 1 in 20 deaths are directly alcohol related. One of the ways in which consuming excessive levels of alcohol can both d
Externí odkaz:
https://doaj.org/article/f2fd059f028742e188d25199ecb0ba9e
Autor:
Silpa Gampala, Hye-ran Moon, Randall Wireman, Jacqueline Peil, Sonia Kiran, Dana K. Mitchell, Kylee Brewster, Henry Mang, Andi Masters, Christine Bach, Whitney Smith-Kinnamen, Emma H. Doud, Ratan Rai, Amber L. Mosley, Sara K. Quinney, D. Wade Clapp, Chafiq Hamdouchi, James Wikel, Chi Zhang, Bumsoo Han, Millie M. Georgiadis, Mark R. Kelley, Melissa L. Fishel
Publikováno v:
Pharmacological Research, Vol 201, Iss , Pp 107092- (2024)
AP endonuclease-1/Redox factor-1 (APE1/Ref-1 or Ref-1) is a multifunctional protein that is overexpressed in most aggressive cancers and impacts various cancer cell signaling pathways. Ref-1′s redox activity plays a significant role in activating t
Externí odkaz:
https://doaj.org/article/aab80d4f3cdf4047a242a19cd4eadd78
Autor:
Christine A. Berryhill, Emma H. Doud, Jocelyne N. Hanquier, Whitney R. Smith-Kinnaman, Devon L. McCourry, Amber L. Mosley, Evan M. Cornett
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 817 (2024)
DZNep (3-deazaneplanocin A) is commonly used to reduce lysine methylation. DZNep inhibits S-adenosyl-l-homocysteine hydrolase (AHCY), preventing the conversion of S-adenosyl-l-homocysteine (SAH) into L-homocysteine. As a result, the SAM-to-SAH ratio
Externí odkaz:
https://doaj.org/article/3affc577ee8d49dc8c5f0c2dd1b4fb8b
Autor:
Christine A. Berryhill, Jocelyne N. Hanquier, Emma H. Doud, Eric Cordeiro-Spinetti, Bradley M. Dickson, Scott B. Rothbart, Amber L. Mosley, Evan M. Cornett
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Lysine methylation modulates the function of histone and non-histone proteins, and the enzymes that add or remove lysine methylation—lysine methyltransferases (KMTs) and lysine demethylases (KDMs), respectively—are frequently mutated and
Externí odkaz:
https://doaj.org/article/6311fa555be4463283a2990dcdaf5815
Autor:
Makayla S. Lancaster, Byungwook Kim, Emma H. Doud, Mason D. Tate, Ahmad D. Sharify, Hongyu Gao, Duojiao Chen, Ed Simpson, Patrick Gillespie, Xiaona Chu, Marcus J. Miller, Yue Wang, Yunlong Liu, Amber L. Mosley, Jungsu Kim, Brett H. Graham
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113241- (2023)
Summary: Lysine succinylation is a subtype of protein acylation associated with metabolic regulation of succinyl-CoA in the tricarboxylic acid cycle. Deficiency of succinyl-CoA synthetase (SCS), the tricarboxylic acid cycle enzyme catalyzing the inte
Externí odkaz:
https://doaj.org/article/3667fe089082442185bcfa19a5753f0c
Autor:
Sarah C. Stanhope, Tal Brandwine-Shemmer, Hannah R. Blum, Emma H. Doud, Amber Jannasch, Amber L. Mosley, Baruch Minke, Vikki M. Weake
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102723- (2023)
The retina is one of the highest oxygen-consuming tissues because visual transduction and light signaling processes require large amounts of ATP. Thus, because of the high energy demand, oxygen-rich environment, and tissue transparency, the eye is su
Externí odkaz:
https://doaj.org/article/a38adced786e401d80ce4ce7f9ef9c3c
Autor:
Ruizhong Wang, Brijesh Kumar, Emma H. Doud, Amber L. Mosley, Matthew S. Alexander, Louis M. Kunkel, Harikrishna Nakshatri
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 231-248 (2022)
miR-486 is a myogenic microRNA, and its reduced skeletal muscle expression is observed in muscular dystrophy. Transgenic overexpression of miR-486 using muscle creatine kinase promoter (MCK-miR-486) partially rescues muscular dystrophy phenotype. We
Externí odkaz:
https://doaj.org/article/a2b5f758d06c43e78d62dda8ba2f597c
Autor:
Ruizhong Wang, Brijesh Kumar, Poornima Bhat-Nakshatri, Aditi S. Khatpe, Michael P. Murphy, Kristen E. Wanczyk, Edward Simpson, Duojiao Chen, Hongyu Gao, Yunlong Liu, Emma H. Doud, Amber L. Mosley, Harikrishna Nakshatri
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106541- (2023)
Summary: Skeletal muscle dysfunction or reprogramming due to the effects of the cancer secretome is observed in multiple malignancies. Although mouse models are routinely used to study skeletal muscle defects in cancer, because of species specificity
Externí odkaz:
https://doaj.org/article/1438aa9d57ba4cedbd600e0d5b03d86c
Autor:
Jie Jiang, Sankalp Srivastava, Sheng Liu, Gretchen Seim, Rodney Claude, Minghua Zhong, Sha Cao, Utpal Davé, Reuben Kapur, Amber L. Mosley, Chi Zhang, Jun Wan, Jing Fan, Ji Zhang
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106425- (2023)
Summary: Intracellular α-ketoglutarate is an indispensable substrate for the Jumonji family of histone demethylases (JHDMs) mediating most of the histone demethylation reactions. Since α-ketoglutarate is an intermediate of the tricarboxylic acid cy
Externí odkaz:
https://doaj.org/article/e5002eac7ce4453eb8015dfa668b7a61