Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Amber L, Couzens"'
Autor:
Thierry Le Bihan, Teresa Nunez de Villavicencio Diaz, Chelsea Reitzel, Victoria Lange, Minyoung Park, Emma Beadle, Lin Wu, Marko Jovic, Rosalin M. Dubois, Amber L. Couzens, Jin Duan, Xiaobing Han, Qixin Liu, Bin Ma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The antibody response to vaccination and infection is a key component of the immune response to pathogens. Sequencing of peripheral B cells may not represent the complete B cell receptor repertoire. Here we present a method for sequencing hu
Externí odkaz:
https://doaj.org/article/cbf7474c80b64058b3ff5ebb09a1b706
Autor:
Magdalena M. Szewczyk, Yoshinori Ishikawa, Shawna Organ, Nozomu Sakai, Fengling Li, Levon Halabelian, Suzanne Ackloo, Amber L. Couzens, Mohammad Eram, David Dilworth, Hideto Fukushi, Rachel Harding, Carlo C. dela Seña, Tsukasa Sugo, Kozo Hayashi, David McLeod, Carlos Zepeda, Ahmed Aman, Maria Sánchez-Osuna, Eric Bonneil, Shinji Takagi, Rima Al-Awar, Mike Tyers, Stephane Richard, Masayuki Takizawa, Anne-Claude Gingras, Cheryl H. Arrowsmith, Masoud Vedadi, Peter J. Brown, Hiroshi Nara, Dalia Barsyte-Lovejoy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Protein arginine methyltransferases (PRMTs) are increasingly recognized as potential therapeutic targets but PRMT7 remains an understudied member of this enzyme family. Here, the authors develop a chemical probe for PRMT7 and apply it to elucidate th
Externí odkaz:
https://doaj.org/article/03bef969e65b4b6bb250bb2886960e81
Autor:
Mandeep K. Gill, Tania Christova, Ying Y. Zhang, Alex Gregorieff, Liang Zhang, Masahiro Narimatsu, Siyuan Song, Shawn Xiong, Amber L. Couzens, Jiefei Tong, Jonathan R. Krieger, Michael F. Moran, Alexandre R. Zlotta, Theodorus H. van der Kwast, Anne-Claude Gingras, Frank Sicheri, Jeffrey L. Wrana, Liliana Attisano
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The Hippo pathway is frequently dysregulated in cancer. Here, the authors identify NUAK2 as negative regulator of the Hippo pathway from a siRNA kinome screen and show that NUAK2 promotes YAP/TAZ nuclear localisation while NUAK2 is a transcriptional
Externí odkaz:
https://doaj.org/article/d30df4cc14bf4f8f98f52cdb55527dcc
Autor:
Jennifer F. Knight, Vanessa Y.C. Sung, Elena Kuzmin, Amber L. Couzens, Danielle A. de Verteuil, Colin D.H. Ratcliffe, Paula P. Coelho, Radia M. Johnson, Payman Samavarchi-Tehrani, Tina Gruosso, Harvey W. Smith, Wontae Lee, Sadiq M. Saleh, Dongmei Zuo, Hong Zhao, Marie-Christine Guiot, Ryan R. Davis, Jeffrey P. Gregg, Christopher Moraes, Anne-Claude Gingras, Morag Park
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3191-3205 (2018)
Summary: Triple-negative breast cancers (TNBCs) display a complex spectrum of mutations and chromosomal aberrations. Chromosome 5q (5q) loss is detected in up to 70% of TNBCs, but little is known regarding the genetic drivers associated with this eve
Externí odkaz:
https://doaj.org/article/f4500191f8be42e7bd824f4c692561b2
Autor:
Cavan Bennett, Moyra Lawrence, Jose A. Guerrero, Simon Stritt, Amie K. Waller, Yahui Yan, Richard W. Mifsud, Jose Ballester-Beltrán, Ayesha Baig, Annett Mueller, Louisa Mayer, James Warland, Christopher J. Penkett, Parsa Akbari, Thomas Moreau, Amanda L. Evans, Souradip Mookerjee, Gary J. Hoffman, Kourosh Saeb-Parsy, David J. Adams, Amber L. Couzens, Markus Bender, Wendy N. Erber, Bernhard Nieswandt, Randy J. Read, Cedric Ghevaert
Publikováno v:
Blood. 139:2227-2239
The process of platelet production has so far been understood to be a 2-stage process: megakaryocyte maturation from hematopoietic stem cells followed by proplatelet formation, with each phase regulating the peripheral blood platelet count. Proplatel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e0ff77a46b889fca56887fe7308296
https://doi.org/10.1182/blood.2021013113
https://doi.org/10.1182/blood.2021013113
Autor:
Magdalena M. Szewczyk, Yoshinori Ishikawa, Shawna Organ, Nozomu Sakai, Fengling Li, Levon Halabelian, Suzanne Ackloo, Amber L. Couzens, Mohammad Eram, David Dilworth, Hideto Fukushi, Rachel Harding, Carlo C. dela Seña, Tsukasa Sugo, Kozo Hayashi, David McLeod, Carlos Zepeda, Ahmed Aman, Maria Sánchez-Osuna, Eric Bonneil, Shinji Takagi, Rima Al-Awar, Mike Tyers, Stephane Richard, Masayuki Takizawa, Anne-Claude Gingras, Cheryl H. Arrowsmith, Masoud Vedadi, Peter J. Brown, Hiroshi Nara, Dalia Barsyte-Lovejoy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/1528be5dba214e53abc1707b3bc5de39
Autor:
Hideto Fukushi, Masayuki Takizawa, Shawna Organ, Masoud Vedadi, Peter Brown, Rima Al-awar, Carlo C. dela Seña, Mike Tyers, Carlos Zepeda, Levon Halabelian, David Dilworth, Suzanne Ackloo, Ahmed Aman, Amber L. Couzens, Yoshinori Ishikawa, David Macleod, Nozomu Sakai, Rachel Harding, Stéphane Richard, Tsukasa Sugo, Anne-Claude Gingras, Hiroshi Nara, Fengling Li, Eric Bonneil, Mohammad S. Eram, Cheryl H. Arrowsmith, Shinji Takagi, Dalia Barsyte-Lovejoy, María Sánchez-Osuna, Kozo Hayashi, Magdalena M. Szewczyk
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Protein arginine methyltransferases (PRMTs) regulate diverse biological processes and are increasingly being recognized for their potential as drug targets. Here we report the discovery of a potent, selective, and cell-active chemical probe for PRMT7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6695ed88c284dadac746547f2c89b8a2
http://europepmc.org/articles/PMC7224190
http://europepmc.org/articles/PMC7224190
Autor:
Levon Halabelian, Nozomu Sakai, David McLeod, Anne-Claude Gingras, Rima Al-awar, Hiroshi Nara, Dalia Barsyte-Lovejoy, Masoud Vedadi, David Dilworth, Hideto Fukushi, Stéphane Richard, Carlos Zepeda, Cheryl H. Arrowsmith, María Sánchez-Osuna, Ahmed Aman, Carlo C. dela Seña, Kozo Hayashi, Suzanne Ackloo, Magdalena M. Szewczyk, Yoshinori Ishikawa, Peter Brown, Fengling Li, Eric Bonneil, Mike Tyers, Mohammad S. Eram, Masayuki Takizawa, Amber L. Couzens, Shawna Organ, Rachel Harding, Shinji Takagi, Tsukasa Sugo
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Protein arginine methyltransferases (PRMTs) regulate diverse biological processes and are increasingly being recognized for their potential as drug targets. Here we report the discovery of a potent, selective, and cell-active chemical probe for PRMT7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb412e86f19159fc6fc6183076c9350
http://europepmc.org/articles/PMC7250816
http://europepmc.org/articles/PMC7250816
Autor:
Michael F. Moran, Anne-Claude Gingras, Alexandre R. Zlotta, Jeffrey L. Wrana, Liliana Attisano, Jiefei Tong, Liang Zhang, Jonathan R. Krieger, Siyuan Song, Masahiro Narimatsu, Theodorus van der Kwast, Mandeep Gill, Tania Christova, Shawn Xiong, Frank Sicheri, Ying Y. Zhang, Amber L. Couzens, Alex Gregorieff
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
In most solid tumors, the Hippo pathway is inactivated through poorly understood mechanisms that result in the activation of the transcriptional regulators, YAP and TAZ. Here, we identify NUAK2 as a YAP/TAZ activator that directly inhibits LATS-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf0a89bb11cb1185482fe4bcf5e432d
https://doaj.org/article/d30df4cc14bf4f8f98f52cdb55527dcc
https://doaj.org/article/d30df4cc14bf4f8f98f52cdb55527dcc
Autor:
Ryan R. Davis, Danielle Angeline de Verteuil, Amber L. Couzens, Anne-Claude Gingras, Payman Samavarchi-Tehrani, Jeffrey P. Gregg, Dongmei Zuo, Vanessa Y.C. Sung, Jennifer F. Knight, Christopher Moraes, Paula P. Coelho, Sadiq M. Saleh, Marie-Christine Guiot, Elena Kuzmin, Hong Zhao, Wontae Lee, Tina Gruosso, Morag Park, Harvey W. Smith, Colin D.H. Ratcliffe, Radia M. Johnson
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3191-3205 (2018)
Cell Reports
Cell Reports
Summary Triple-negative breast cancers (TNBCs) display a complex spectrum of mutations and chromosomal aberrations. Chromosome 5q (5q) loss is detected in up to 70% of TNBCs, but little is known regarding the genetic drivers associated with this even
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efef3c80e16f8ec1d6be6c68b6e7322d
http://www.sciencedirect.com/science/article/pii/S221112471830305X
http://www.sciencedirect.com/science/article/pii/S221112471830305X