Application of adipose tissue-derived stem cell therapy with a clinically relevant dose does not significantly affect atherosclerotic plaque characteristics in a streptozotocin-induced hyperglycaemia mouse model

Autor: Amber Korn, Suat Simsek, Mitchell D. Fiet, Ingeborg S.E. Waas, Hans W.M. Niessen, Paul A.J. Krijnen

Publikováno v: Journal of Molecular and Cellular Cardiology Plus, Vol 9, Iss , Pp 100083- (2024)

Aims: Diabetes mellitus (DM) induces increased inflammation of atherosclerotic plaques, resulting in elevated plaque instability. Mesenchymal stem cell (MSC) therapy was shown to decrease plaque size and increase stability in non-DM animal models. We

Externí odkaz: https://doaj.org/article/b1d59157f3b243be9892a8ff0c6d204f

A proteome comparison between human fetal and mature renal extracellular matrix identifies EMILIN1 as a regulator of renal epithelial cell adhesion

Autor: Laura Louzao-Martinez, Christian G.M. van Dijk, Yan Juan Xu, Amber Korn, Nicolaas J. Bekker, Romi Brouwhuis, Maria Novella Nicese, Jeroen A.A. Demmers, Marie-José T.H. Goumans, Rosalinde Masereeuw, Dirk J. Duncker, Marianne C. Verhaar, Caroline Cheng

Publikováno v: Matrix Biology Plus, Vol 4, Iss , Pp - (2019)

Cell-based approaches using tissue engineering and regenerative medicine to replace damaged renal tissue with 3D constructs is a promising emerging therapy for kidney disease. Besides living cells, a template provided by a scaffold based on biomateri

Externí odkaz: https://doaj.org/article/d49840d1cd9f4f2b99a9d8ffdea82076

Myocardial infarction coincides with increased NOX2 and Nε-(carboxymethyl) lysine expression in the cerebral microvasculature

Autor: Umit Baylan, Amber Korn, Hans W M Niessen, Paul A J Krijnen, Casper G. Schalkwijk, S. Simsek

Publikováno v: Open Heart, 8(2):e001842. BMJ Publishing Group
Korn, A, Baylan, U, Simsek, S, Schalkwijk, C G, Niessen, H W M & Krijnen, P A J 2021, ' Myocardial infarction coincides with increased NOX2 and Nε-(carboxymethyl) lysine expression in the cerebral microvasculature ', Open Heart, vol. 8, no. 2, 001842 . https://doi.org/10.1136/openhrt-2021-001842, https://doi.org/10.1136/openhrt-2021-001842
Open Heart, Vol 8, Iss 2 (2021)
Open Heart, 8(2):001842. BMJ Publishing Group
Open Heart

BackgroundMyocardial infarction (MI) is associated with mental health disorders, in which neuroinflammation and cerebral microvascular dysfunction may play a role. Previously, we have shown that the proinflammatory factors Nε-(carboxymethyl)lysine (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ed6696a0089572bc066fe1b0615002
https://doi.org/10.1136/openhrt-2021-001842