Výsledky vyhledávání - "Amber Gunderwala"

Autor: Amber Gunderwala, Nicholas Cope, Zhihong Wang

Publikováno v: Current opinion in chemical biology. 71

The role of BRAF in tumor initiation has been established, however, the precise mechanism of autoinhibition has only been illustrated recently by several structural studies. These structures uncovered the basis by which the regulatory domains engage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdf9abf80960b5db8d0e7d826348c60
https://pubmed.ncbi.nlm.nih.gov/36067564

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Analyses of the oncogenic BRAFD594G variant reveal a kinase-independent function of BRAF in activating MAPK signaling

Autor: Zhiwei Liu, Borna Novak, Matthew Connolly, Nicholas Cope, Maria Cavallo, Amber Gunderwala, Zhihong Wang

Publikováno v: Journal of Biological Chemistry. 295:2407-2420

Class 3 mutations in B-Raf proto-oncogene, Ser/Thr kinase (BRAF), that result in kinase-impaired or kinase-dead BRAF have the highest mutation frequency in BRAF gene in lung adenocarcinoma. Several studies have reported that kinase-dead BRAF variants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b2876f940d14709508a473296eac7ca
https://doi.org/10.1074/jbc.ra119.011536

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Biochemical Characterization of Full‐Length Oncogenic BRAF V600E together with Molecular Dynamics Simulations Provide Insight into the Activation and Inhibition Mechanisms of RAF Kinases

Autor: Zhiwei Liu, Zhihong Wang, Borna Novak, Kenneth Wong, Amber Gunderwala, Maria Cavallo, Yana Li, Nicholas Cope, Christine Candelora

Publikováno v: ChemBioChem. 20:2850-2861

The most prevalent BRAF mutation, V600E, occurs frequently in melanoma and other cancers. Although extensive progress has been made toward understanding the biology of RAF kinases, little in vitro characterization of full-length BRAFV600E is availabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d489f12ef1bd20f5b082e23c5912a5b7
https://doi.org/10.1002/cbic.201900266

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Development of an allosteric inhibitor of BRAF targeting the BRAF dimer interface

Autor: Amber Gunderwala

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8b1979e1ac2a1e883623d027756ff7
https://doi.org/10.1021/scimeetings.0c02590

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Development of Allosteric BRAF Peptide Inhibitors Targeting the Dimer Interface of BRAF

Autor: Zhihong Wang, Amber Gunderwala, Anushri A. Nimbvikar, Zhijun Li, Nicholas Cope

Publikováno v: ACS chemical biology. 14(7)

BRAF is the most frequently mutated kinase in human cancers and is one of the major effectors of oncogenic RAS, making BRAF a target of considerable interest for anti-cancer drug development. Wild-type BRAF and a variety of oncogenic BRAF mutants are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7326c263035b14c637825d9fcc9d66
https://pubmed.ncbi.nlm.nih.gov/31243962

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Biochemical Characterization of Full-Length Oncogenic BRAF

Autor: Nicholas, Cope, Borna, Novak, Christine, Candelora, Kenneth, Wong, Maria, Cavallo, Amber, Gunderwala, Zhiwei, Liu, Yana, Li, Zhihong, Wang

Publikováno v: Chembiochem : a European journal of chemical biology. 20(22)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9da5ead3fe67b2b06d0b14e9b3bb990e
https://pubmed.ncbi.nlm.nih.gov/31152574

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A luminescence assay for natural product inhibitors of the Mycobacterium tuberculosis proteasome

Autor: John R. Porter, Amber Gunderwala

Publikováno v: Phytochemical Analysis. 27:126-132

Introduction Mycobacterium tuberculosis (Mtb) causes a large global burden of disease, with a high mortality rate in healthy and immuno-compromised patients. A number of molecular targets have been identified for treatment of this disease, including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ca2ad42d95c4530a160375bb26cc472
https://doi.org/10.1002/pca.2607

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Cover Feature: Biochemical Characterization of Full‐Length Oncogenic BRAF V600E together with Molecular Dynamics Simulations Provide Insight into the Activation and Inhibition Mechanisms of RAF Kinases (ChemBioChem 22/2019)

Autor: Kenneth Wong, Nicholas Cope, Maria Cavallo, Amber Gunderwala, Zhihong Wang, Yana Li, Christine Candelora, Zhiwei Liu, Borna Novak

Publikováno v: ChemBioChem. 20:2802-2802

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0aacaa4fec785fd8efd7aaf3df8a7a2
https://doi.org/10.1002/cbic.201900645

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A luminescence assay for natural product inhibitors of the Mycobacterium tuberculosis proteasome

Autor: Amber, Gunderwala, John, Porter

Publikováno v: Phytochemical analysis : PCA. 27(2)

Mycobacterium tuberculosis (Mtb) causes a large global burden of disease, with a high mortality rate in healthy and immuno-compromised patients. A number of molecular targets have been identified for treatment of this disease, including the Mtb prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4204d29ab1bf556ef2e26951b4bf065a
https://pubmed.ncbi.nlm.nih.gov/26778282

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