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Autor:
Suzanne Y. Guénette, Anja Capell, Rudolph E. Tanzi, Jing Chen, Amber Ferland, Christian Haass
Publikováno v:
Journal of Neurochemistry. 73:985-993
The amyloid precursor protein (APP) is processed in the secretory and endocytic pathways, where both the neuroprotective alpha-secretase-derived secreted APP (APPs alpha) and the Alzheimer's disease-associated beta-amyloid peptide are generated. All