Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Amber E. de Groot"'
Autor:
Amber E. de Groot, Kayla V. Myers, Timothy E.G. Krueger, W. Nathaniel Brennen, Sarah R. Amend, Kenneth J. Pienta
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 32, Iss , Pp 100830- (2022)
Tumor-associated macrophages (TAMs) are an abundant tumor-promoting cell type in the tumor microenvironment (TME). Most TAMs exhibit a pro-tumor M2-like phenotype supportive of tumor growth, immune evasion, and metastasis. IL-4 and IL-13 are major cy
Externí odkaz:
https://doaj.org/article/cb19fe109d0b4254af26572f404fa1e7
Autor:
Paul Foster, Amita Patnaik, Lisa Seitz, Dana Piovesan, Soonweng Cho, Xiaoning Zhao, Amy E Anderson, Nigel Walker, Hema Singh, Casey G Mitchell, Matthew J Walters, Kelsey E Sivick Gauthier, Amber E de Groot, Rebecca D Ray, Nina K Serwas
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/10611e68676a41a18ee0431cb913124e
Autor:
Zhongyuan Zhang, W. Nathaniel Brennen, Angelo M. De Marzo, Alexandria Brame, Levent Trabzonlu, Sarah R. Amend, Denis Wirtz, Timothy E. G. Krueger, Ashley Kiemen, Amber E. de Groot, Kayla V. Myers, Kenneth J. Pienta, Vicente E Torres, Natalia H Nagy
Publikováno v:
Prostate
Background Tumor-associated macrophages (TAMs) are critical components of the tumor microenvironment (TME) in prostate cancer. Commonly used orthotopic models do not accurately reflect the complete TME of a human patient or the natural initiation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0986f8b6e2a6770c152a0596683c2533
https://doi.org/10.1002/pros.24139
https://doi.org/10.1002/pros.24139
Autor:
Kayla V. Myers, Amber E. de Groot, Anna L. Gonye, Luke V. Loftus, Sarah R. Amend, Kenneth J. Pienta
Publikováno v:
Cancer Research. 82:2546-2546
The prostate cancer tumor microenvironment (TME) is comprised of many different components and cell types that influence tumor progression and patient outcome. Macrophages are highly abundant immune cells in the prostate cancer TME. Macrophage phenot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e433c4eae5f4190c34fd63d9afb6a18a
https://doi.org/10.1158/1538-7445.am2022-2546
https://doi.org/10.1158/1538-7445.am2022-2546
Autor:
Kelsey E Sivick Gauthier, Dana Piovesan, Amber E de Groot, Gabrielle L Reiner, Patrick G Schweickert, Ferdie Soriano, Ada Chen, Hema Singh, Xiaoning Zhao, Lisa Seitz, Anita Reddy, Stephen W Young, Nigel Walker, Matthew J Walters
Publikováno v:
The Journal of Immunology. 208:120.13-120.13
TIGIT is an inhibitory receptor expressed primarily on NK and T cell subsets, and binding to its cognate receptor ligand, CD155, results in multiple mechanisms of immunosuppression. Blocking the TIGIT-CD155 interaction in the context of cancer promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba95bf6da179c69b8d280e9d6ac36c60
https://doi.org/10.4049/jimmunol.208.supp.120.13
https://doi.org/10.4049/jimmunol.208.supp.120.13
Autor:
Raul Calvo, Noel Southall, Lixin Fan, Chan Young Ock, Keyur Talsania, Clayton Yates, Taylor Aiken, Yansong Bian, Zachary Knotts, Yongmei Zhao, Jesse M. Jaynes, Jason White, Abisola Abisoye-Ogunniyan, Taivan Odzorig, Anghesom Ghebremedhin, Myagmarjav Dashnyam, Anton Simeonov, Sarangan Ravichandran, Nathan Pate, Amber E. de Groot, Michael Ronzetti, Xin Hu, Vicky Chen, Jelani C. Zarif, Henry Lopez, Bolormaa Baljinnyam, Parimal Kumar, Dandan Li, Natalia de Val, Theresa Guerin, Wendy Bautista, Ahmad Bin Salam, Rushikesh Sable, Juan J. Marugan, Marc Ferrer, Serguei Kozlov, Victoria Nguyen, Monika Mehta, Balasubramanyam Karanam, Ruksana Amin, Mones Abu-Asab, Udo Rudloff, Anju Singh
Publikováno v:
Sci Transl Med
Solid tumors elicit a detectable immune response including the infiltration of tumor-associated macrophages (TAMs). Unfortunately, this immune response is co-opted into contributing toward tumor growth instead of preventing its progression. We seek t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513d18826af0875f5379d90cda6894d2
https://doi.org/10.1126/scitranslmed.aax6337
https://doi.org/10.1126/scitranslmed.aax6337
Autor:
Amber E. de Groot, Kenneth J. Pienta
Publikováno v:
Oncotarget
The progression of cancer is a result of not only the growth of the malignant cells but also the behavior of other components of the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are key components of the TME that influence tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb49fbfd0bc0a8b7539237cd1e129d8
https://doi.org/10.18632/oncotarget.24556
https://doi.org/10.18632/oncotarget.24556
Publikováno v:
Molecular Cancer Research. 15:361-370
Metastasis is the consequence of a cancer cell that disperses from the primary tumor, travels throughout the body, and invades and colonizes a distant site. On the basis of Paget's 1889 hypothesis, the majority of modern metastasis research focuses o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8930ac15793a204c141cb09bfe4f0350
https://doi.org/10.1158/1541-7786.mcr-16-0436
https://doi.org/10.1158/1541-7786.mcr-16-0436
Cancers are not composed merely of cancer cells alone; instead, they are complex ‘ecosystems’ comprising many different cell types and noncellular factors. The tumour stroma is a critical component of the tumour microenvironment, where it has cru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589bd4146114045e1fe11d8e7dd3b727
https://europepmc.org/articles/PMC5960434/
https://europepmc.org/articles/PMC5960434/
Autor:
Changxue Lu, Amber E. de Groot, Jun Luo, Liang Dong, Zhongyuan Zhang, Kenneth J. Pienta, Diane K. Reyes, Sarah R. Amend
Publikováno v:
Cancer Research. 79:1383-1383
Purpose: The presence of circulating tumor cells (CTC) in blood is associated with poor prognosis in metastatic prostate cancer (mPCa) patients. For non-metastatic PCa patients and patients with biochemical recurrence (BCR), it is extremely difficult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cd2645192836a84d2c72f43c6580a11
https://doi.org/10.1158/1538-7445.am2019-1383
https://doi.org/10.1158/1538-7445.am2019-1383