Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Amber E Alsop"'
Autor:
Rachel T Uren, Martin O’Hely, Sweta Iyer, Ray Bartolo, Melissa X Shi, Jason M Brouwer, Amber E Alsop, Grant Dewson, Ruth M Kluck
Publikováno v:
eLife, Vol 6 (2017)
During apoptosis, Bak and Bax undergo major conformational change and form symmetric dimers that coalesce to perforate the mitochondrial outer membrane via an unknown mechanism. We have employed cysteine labelling and linkage analysis to the full len
Externí odkaz:
https://doaj.org/article/48645ef9a7cc4f43a59462f285e8cf9b
Autor:
Shunsuke Suzuki, Ryuichi Ono, Takanori Narita, Andrew J Pask, Geoffrey Shaw, Changshan Wang, Takashi Kohda, Amber E Alsop, Jennifer A Marshall Graves, Yuji Kohara, Fumitoshi Ishino, Marilyn B Renfree, Tomoko Kaneko-Ishino
Publikováno v:
PLoS Genetics, Vol 3, Iss 4, p e55 (2007)
Among mammals, only eutherians and marsupials are viviparous and have genomic imprinting that leads to parent-of-origin-specific differential gene expression. We used comparative analysis to investigate the origin of genomic imprinting in mammals. PE
Externí odkaz:
https://doaj.org/article/cb99db35b59c4640b66f161e867606e6
Autor:
Ricky W. Johnstone, Andreas Villunger, Anna Frenzel, Clare L. Scott, Rachael Ralli, Kellie-Marie Banks, Steven P. Williams, Leonie A. Cluse, Michael Bots, Amber E. Alsop, Adrian P. Wiegmans
Supplementary Figures 1-8 from Deciphering the Molecular Events Necessary for Synergistic Tumor Cell Apoptosis Mediated by the Histone Deacetylase Inhibitor Vorinostat and the BH3 Mimetic ABT-737
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250e813b74f7ea7417eb0fdb85d9f589
https://doi.org/10.1158/0008-5472.22389305
https://doi.org/10.1158/0008-5472.22389305
Autor:
David C.S. Huang, Amber E. Alsop, Wai Shan Yuen, Grant Dewson, Khatira Anwari, Ruth M. Kluck, Nicholas A. Smith, John L. Carroll, Brian J. Smith, Sweta Iyer
Publikováno v:
ResearcherID
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
During apoptosis, Bak and Bax are activated by BH3-only proteins binding to the α2–α5 hydrophobic groove; Bax is also activated via a rear pocket. Here we report that antibodies can directly activate Bak and mitochondrial Bax by binding to the α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a389d82c2bc8601be7026532200662c6
Autor:
Tobias Kratina, Ruth M. Kluck, Amber E. Alsop, Mark Xiang Li, Grant Dewson, Iris K. L. Tan, Michael A. Dengler, Colin Hockings, Stephen B. Ma
Publikováno v:
Proceedings of the National Academy of Sciences. 114:7629-7634
BAK and BAX are the essential effectors of apoptosis because without them a cell is resistant to most apoptotic stimuli. BAK and BAX undergo conformation changes to homooligomerize then permeabilize the mitochondrial outer membrane during apoptosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc3a68f9f6a2e7b9d217a0b895f93ba
https://doi.org/10.1073/pnas.1702453114
https://doi.org/10.1073/pnas.1702453114
Autor:
Colin Hockings, Amber E. Alsop, Grant Dewson, W. Douglas Fairlie, Erinna F. Lee, Stephanie Fennell, Ruth M. Kluck
The prosurvival Bcl-2 family proteins Mcl-1 and Bcl-x(L) inhibit apoptosis by sequestering BH3-only proteins such as Bid and Bim (MODE 1) or the effector proteins Bak and Bax (MODE 2). To better understand the contributions of MODE 1 and MODE 2 in bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa0b6ebb287a69e2867d8941f88a058
https://europepmc.org/articles/PMC5864222/
https://europepmc.org/articles/PMC5864222/
Autor:
Mark J. Smyth, Andreas Strasser, Gabrielle T. Belz, Axel Kallies, Nicholas J. Bernard, Lisa Rödling, Lynn M. Corcoran, Amber E. Alsop, Frederick Masson, David M. Tarlinton, Lorraine A. O'Reilly, Ricky W. Johnstone, Stephen L. Nutt, Dimitra Zotos, Jennifer A. Walker, Shoukat Afshar-Sterle, Anna K. Scherger
Publikováno v:
Nature Medicine
Nature Medicine, Nature Publishing Group, 2014, 20 (3), pp.283-290. ⟨10.1038/nm.3442⟩
Nature Medicine, Nature Publishing Group, 2014, 20 (3), pp.283-290. ⟨10.1038/nm.3442⟩
Loss of function of the tumor suppressor gene PRDM1 (also known as BLIMP1) or deregulated expression of the oncogene BCL6 occurs in a large proportion of diffuse large B cell lymphoma (DLBCL) cases. However, targeted mutation of either gene in mice l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8211ee28fb070c030f09e92e428f06
https://doi.org/10.1038/nm.3442
https://doi.org/10.1038/nm.3442
Autor:
Amber E. Alsop, V.W. Wen, Narci C. Teoh, Nicholas A. Shackel, Sharon Pok, Geoffrey C. Farrell, Aude M. Fahrer, Pawan Pyakurel
Publikováno v:
Journal of Gastroenterology and Hepatology. 28:1545-1554
Background and Aim By array-comparative genomic hybridization, we demonstrated cyclin E as one of seven genes associated with hepatocellular carcinoma (HCC) development in Ku70 DNA repair-deficient mice. We therefore explored the hypothesis that duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87296e2da0f20e58d8f619d601d53a95
https://doi.org/10.1111/jgh.12216
https://doi.org/10.1111/jgh.12216
Autor:
Rachel T Uren, Ray Bartolo, Jason M. Brouwer, Martin O'Hely, Grant Dewson, Ruth M. Kluck, Sweta Iyer, Amber E. Alsop
During apoptosis, Bak and Bax undergo major conformational change and form symmetric dimers that coalesce to perforate the mitochondrial outer membrane via an unknown mechanism. We have employed cysteine labelling and linkage analysis to the full len
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139e3b223a1752cfbed7adf4d5ac1f50
https://doi.org/10.1101/059899
https://doi.org/10.1101/059899