Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Amber D Lockridge"'
Autor:
Brian Akhaphong, Daniel C. Baumann, Megan Beetch, Amber D. Lockridge, Seokwon Jo, Alicia Wong, Tate Zemanovic, Ramkumar Mohan, Danica L. Fondevilla, Michelle Sia, Maria Ruth B. Pineda-Cortel, Emilyn U. Alejandro
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
Fetal growth restriction, or low birth weight, is a strong determinant for eventual obesity and type 2 diabetes. Clinical studies suggest placental mechanistic target of rapamycin (mTOR) signaling regulates fetal birth weight and the metabolic health
Externí odkaz:
https://doaj.org/article/2188b8bb4a594bf4ac7526c1cf4a3c92
Publikováno v:
Diabetes. 71
T2D is associated with reduced pancreatic β-cell mass, in part, by increased apoptosis and identity loss as insulin-producing cells. Nutrient-sensor protein O-GlcNAc Transferase (Ogt) is a regulator of pancreas development and β-cell function. We h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c40094764627b4715de0509f8567548e
https://doi.org/10.2337/db22-1445-p
https://doi.org/10.2337/db22-1445-p
Autor:
Seokwon Jo, Juan E. Abrahante-Lloréns, Elina da Sol Chung, Ramkumar Mohan, Xiaoyong Yang, Hai Bin Ruan, Emilyn U. Alejandro, Eunice Oribamise, Amber D Lockridge
Publikováno v:
Cells
Cells, Vol 10, Iss 2801, p 2801 (2021)
Volume 10
Issue 10
Cells, Vol 10, Iss 2801, p 2801 (2021)
Volume 10
Issue 10
The nutrient-sensor O-GlcNAc transferase (Ogt), the sole enzyme that adds an O-GlcNAc-modification onto proteins, plays a critical role for pancreatic β-cell survival and insulin secretion. We hypothesized that β-cell Ogt overexpression would confe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff17aaa37d8578f5b3c2d8b06c61a199
http://europepmc.org/articles/PMC8534823
http://europepmc.org/articles/PMC8534823
Autor:
Ramkumar Mohan, Amber D Lockridge, Yoshio Fujitani, Ernesto Bernal-Mizrachi, Arthur C. Eschenlauer, Seokwon Jo, Emilyn U. Alejandro, Kevin Murray, Deborah A. Ferrington
Publikováno v:
Diabetes
O-GlcNAc transferase (OGT), a nutrient sensor sensitive to glucose flux, is highly expressed in the pancreas. However, the role of OGT in the mitochondria of β-cells is unexplored. In this study, we identified the role of OGT in mitochondrial functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b66681fda701c46fa93d024cc98be6b
https://doi.org/10.2337/figshare.15831735
https://doi.org/10.2337/figshare.15831735
Autor:
Ramkumar Mohan, Tate Zemanovic, Emilyn U. Alejandro, Danica L. Fondevilla, Seokwon Jo, Brian Akhaphong, Alicia Wong, Michelle Sia, Megan M Beetch, Amber D Lockridge, Daniel C. Baumann, Maria Ruth B. Pineda-Cortel
Publikováno v:
JCI Insight
Fetal growth restriction, or low birth weight, is a strong determinant for eventual obesity and type 2 diabetes. Clinical studies suggest placental mechanistic target of rapamycin (mTOR) signaling regulates fetal birth weight and the metabolic health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7551018991b8a8659b5c6b003adf186c
https://doi.org/10.1172/jci.insight.149271
https://doi.org/10.1172/jci.insight.149271
Publikováno v:
Journal of Biological Chemistry. 294:13040-13050
An early hallmark of type 2 diabetes is a failure of proinsulin-to-insulin processing in pancreatic β-cells, resulting in hyperproinsulinemia. Proinsulin processing is quite sensitive to nutrient flux, and β-cell–specific deletion of the nutrient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a7d4613dd3abe91d22a4019408eeb67
https://doi.org/10.1074/jbc.ra119.008670
https://doi.org/10.1074/jbc.ra119.008670
Repeated exposure to stress results in progressively divergent effects on cognitive behaviors that are dependent on the integrity of networks in the medial prefrontal cortex (mPFC). To investigate molecular mechanisms responsive to variable repetitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6a202a72ae18889f6bc4a141321522f
https://doi.org/10.1101/2021.03.10.434848
https://doi.org/10.1101/2021.03.10.434848
Publikováno v:
Cells
Volume 10
Issue 1
Cells, Vol 10, Iss 93, p 93 (2021)
Volume 10
Issue 1
Cells, Vol 10, Iss 93, p 93 (2021)
Insulin-secreting pancreatic &beta
cells express proteins characteristic of D-serine regulated synapses, but the acute effect of D-serine co-agonism on its presumptive &beta
cell target, N-methyl D-aspartate receptors (NMDARs), is unclear.
cells express proteins characteristic of D-serine regulated synapses, but the acute effect of D-serine co-agonism on its presumptive &beta
cell target, N-methyl D-aspartate receptors (NMDARs), is unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8329cf73095247ddac0b950594ea1ec
http://europepmc.org/articles/PMC7826616
http://europepmc.org/articles/PMC7826616
Autor:
Megan M Beetch, Ahmad Essawy, Emilyn U. Alejandro, Eric C. Gustafson, Amber D Lockridge, Seokwon Jo
Publikováno v:
The Journal of Biological Chemistry
The nutrient sensor O-GlcNAc transferase (OGT) catalyzes posttranslational addition of O-GlcNAc onto target proteins, influencing signaling pathways in response to cellular nutrient levels. OGT is highly expressed in pancreatic glucagon-secreting cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85c264e396a1d78c0ec160f5f38f8c7
https://pubmed.ncbi.nlm.nih.gov/33460647
https://pubmed.ncbi.nlm.nih.gov/33460647
Autor:
Niklas E. Damberg, Eric C. Gustafson, Juan E. Abrahante, Miranda Olson, Ramkumar Mohan, Seokwon Jo, Emilyn U. Alejandro, Amber D Lockridge
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp-(2020)
Cell Rep
Cell Rep
Summary During early obesity, pancreatic β cells compensate for increased metabolic demand through a transient phase of insulin hypersecretion that stabilizes blood glucose and forestalls diabetic progression. We find evidence that β cell O-GlcNAcy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3331cfaec79066b60022c6b54779b9
http://www.sciencedirect.com/science/article/pii/S2211124720305581
http://www.sciencedirect.com/science/article/pii/S2211124720305581