Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Amber C. Donahue"'
Autor:
Maher Albitar, Francis Giles, Michael Keating, Jorge Cortes, Zeev Estrov, Elihu Estey, Susan O'Brien, Zhong J. Zhang, Xi Zhang, Amber C. Donahue, Benjamin Bekele, Hagop Kantarjian, Wanlong Ma
Purpose: Cytogenetic abnormalities are currently the most important predictors of response and clinical outcome for patients with acute myeloid leukemia (AML) or advanced-stage myelodysplastic syndrome (MDS). Because clinical outcomes vary markedly w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f9a71c46b0fc1335d27e5216c074be
https://doi.org/10.1158/1078-0432.c.6517486.v1
https://doi.org/10.1158/1078-0432.c.6517486.v1
Autor:
Amber C. Donahue, Peng Yen-Lin
Publikováno v:
Cancer Immunology ISBN: 9783030308445
Cancer Immunology ISBN: 9783662440056
Cancer Immunology ISBN: 9783662440056
Many of the immunological methods currently used in laboratory testing for cancer are based on the use of antibodies, including many diagnostic and prognostic tests, as well as some tests intended to inform treatment decisions. Unlocking the genetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a8bc95d0bd14b677f7ae355441911e
https://doi.org/10.1007/978-3-030-30845-2_28
https://doi.org/10.1007/978-3-030-30845-2_28
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e15407 (2010)
Current diagnostic screening strategies based on karyotyping or fluorescent in situ hybridization (FISH) for detection of chromosomal abnormalities in chronic lymphocytic leukemia (CLL) are laborious, time-consuming, costly, and have limitations in r
Externí odkaz:
https://doaj.org/article/71f4e9af01454d34844d83075eb1c907
Autor:
Thomas Powles, James Larkin, Paul B. Robbins, Jie Pu, Xinmeng Jasmine Mu, John B. A. G. Haanen, Amber C Donahue, Toni K. Choueiri, Robert J. Motzer, Alessandra di Pietro, Brian I. Rini, Despina Thomaidou
Publikováno v:
Journal of Clinical Oncology. 39:4547-4547
4547 Background: In the phase 3 JAVELIN Renal 101 trial (NCT02684006), treatment-naive patients (pts) with aRCC demonstrated prolonged progression-free survival (PFS) and a higher objective response rate with A + Ax vs S. We report the association of
Autor:
John B. A. G. Haanen, Toni K. Choueiri, Xinmeng Jasmine Mu, Weidong Zhang, Sumanta K. Pal, Thomas Powles, Xiao Wang, Paul B. Robbins, Konstantin Penkov, Amber C Donahue, Jing Wang, Aleksander Chudnovsky, James Larkin, Gwenaelle Gravis, Boris Alekseev, Subramanian Hariharan, Laurence Albiges, Matthew T. Campbell, Keith A. Ching, Robert J. Motzer, Alessandra di Pietro, Motohide Uemura, Jae-Lyun Lee
Publikováno v:
Nat Med
We report on molecular analyses of baseline tumor samples from the phase 3 JAVELIN Renal 101 trial (n = 886; NCT02684006 ), which demonstrated significantly prolonged progression-free survival (PFS) with first-line avelumab + axitinib versus sunitini
Publikováno v:
Leukemia Research. 35:1477-1483
Current strategies for detecting chromosome abnormalities in MDS/AML include FISH or traditional cytogenetics. MLPA detects abnormalities in multiple loci simultaneously, with higher resolution and throughput. Peripheral blood from 50 healthy subject
Autor:
Elihu H. Estey, Wanlong Ma, Benjamin N. Bekele, Hagop M. Kantarjian, Zhong J. Zhang, Maher Albitar, Jorge E. Cortes, Amber C. Donahue, Zeev Estrov, Francis J. Giles, Susan O'Brien, Xi Zhang, Michael J. Keating
Publikováno v:
Clinical Cancer Research. 15:3820-3826
Purpose: Cytogenetic abnormalities are currently the most important predictors of response and clinical outcome for patients with acute myeloid leukemia (AML) or advanced-stage myelodysplastic syndrome (MDS). Because clinical outcomes vary markedly w
Autor:
Iman Jilani, Michael J. Keating, Xi Zhang, Amber C. Donahue, Elihu H. Estey, Hagop M. Kantarjian, Susan O'Brien, Wanlong Ma, Maher Albitar, Mohammad Reza Sheikholeslami, Farhad Ravandi, Francis J. Giles
Publikováno v:
Cancer Biomarkers. 5:51-58
Roughly one-third of acute myeloid leukemia (AML) patients exhibit mutations in the nucleophosmin (NPM1) gene, and multiple studies have linked these mutations with a more favorable clinical outcome. We developed an assay for the detection of NPM1 mu
Autor:
David A. Fruman, Amber C. Donahue
Publikováno v:
European Journal of Immunology. 37:2923-2936
Phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR), a downstream kinase, are both required for proliferation of splenic B cells. However, the functions of PI3K and mTOR in response to different stimuli and among B cell subs
Publikováno v:
European Journal of Immunology. 34:2968-2976
Phosphoinositide 3-kinase (PI3K) is a ubiquitously expressed signaling enzyme that plays an integral role in development and activation of B cells. B cell receptor (BCR)-driven proliferation is completely blocked either in cells lacking the p85α reg