Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Amber Bradley"'
Autor:
Chunhua Dai, Yue Zhang, Yulong Gong, Amber Bradley, Zihan Tang, Katelyn Sellick, Shristi Shrestha, Erick Spears, Brittney A. Covington, Jade Stanley, Regina Jenkins, Tiffany M. Richardson, Rebekah A. Brantley, Katie Coate, Diane C. Saunders, Jordan J. Wright, Marcela Brissova, E. Danielle Dean, Alvin C. Powers, Wenbiao Chen
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111447- (2024)
Summary: Increased blood amino acid levels (hyperaminoacidemia) stimulate pancreas expansion by unclear mechanisms. Here, by genetic and pharmacological disruption of glucagon receptor (GCGR) in mice and zebrafish, we found that the ensuing hyperamin
Externí odkaz:
https://doaj.org/article/2ee032232bfd42259a0d71c3c02e2ba8
Autor:
CHUNHUA DAI, AMBER BRADLEY, ERICK SPEARS, AJAY K. SINGH, FAVOUR O. OLADIPUPO, REGINA JENKINS, KATIE C. COATE, ALVIN C. POWERS
Publikováno v:
Diabetes. 71
The determinants of delta cell mass are not known. As part of studies showing interruption of glucagon signaling (IGS) stimulates alpha cell proliferation in an amino acid (AA) -dependent manner, we noted an increase in delta cells. To investigate, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e48b1fdcfac3123013e81edbee99499
https://doi.org/10.2337/db22-365-or
https://doi.org/10.2337/db22-365-or
Autor:
YASMINYE D. PETTWAY, CHUNHUA DAI, TIFFANY M. RICHARDSON, JOHN T. WALKER, RADHIKA ARAMANDLA, GREG POFFENBERGER, AMBER BRADLEY, ALVIN C. POWERS, MARCELA BRISSOVA
Publikováno v:
Diabetes. 71
We previously showed that α cell function and gene expression in islets from donors with type 1 diabetes (T1D) was significantly compromised. The reason (s) for these intrinsic α cell changes are unknown but may include loss of α-to-β cell contac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6575f74600085174a73b23d3699a7b30
https://doi.org/10.2337/db22-367-or
https://doi.org/10.2337/db22-367-or
Autor:
Greg Poffenberger, Danielle Dean, Jordan J. Wright, Chunhua Dai, Marcela Brissova, Katie C. Coate, Erick Spears, Shristi Shrestha, Alvin C. Powers, Amber Bradley
Publikováno v:
Diabetes. 69
Interruption of glucagon signaling by glucagon receptor gene inactivation or treatment with a glucagon receptor blocking monoclonal antibody (GCGR-Ab) stimulates alpha cell proliferation and expansion. Surprisingly, pancreas weight is also increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09daed2046eb089d6f2eec8f8184d7b4
https://doi.org/10.2337/db20-1894-p
https://doi.org/10.2337/db20-1894-p
Autor:
Xi Chen, Wei Ning, Vishruth K. Reddy, Sarah P. Short, Amber Bradley, Christopher S. Williams, Kristina E. Hill, Tanner J. Freeman, Caitlyn W. Barrett, Mary K. Lintel, Noah F. Shroyer, Jefferson E. Vallance, Mary Kay Washington, Barbara Fingleton, Keith T. Wilson, Amy K. Motley, Raymond F. Burk, Bobak Parang, Shenika Poindexter
Publikováno v:
Journal of Clinical Investigation. 125:2646-2660
Patients with inflammatory bowel disease are at increased risk for colon cancer due to augmented oxidative stress. These patients also have compromised antioxidant defenses as the result of nutritional deficiencies. The micronutrient selenium is esse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33397fc4808339ef39e4fa1d64d6b84e
https://doi.org/10.1172/jci76099
https://doi.org/10.1172/jci76099
Autor:
Li J, Melissa A. Fischer, Sarah P. Short, Yash A. Choksi, Christopher S. Williams, Scott W. Hiebert, Frank Revetta, Keith T. Wilson, Bing Zhang, Michael J. Rosen, Mary Kay Washington, Caitlyn W. Barrett, Rishi D. Naik, Elizabeth M. McDonough, Xi Chen, Lori A. Coburn, Mukul K. Mittal, Amber Bradley, J. Joshua Smith, Joshua J. Thompson, Bobak Parang, Shenika Poindexter
Publikováno v:
JCI Insight. 2
MTG16 is a member of the myeloid translocation gene (MTG) family of transcriptional corepressors. While MTGs were originally identified in chromosomal translocations in acute myeloid leukemia, recent studies have uncovered a role in intestinal biolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f06d9fa3cfa6c4ed7137ff2b173c67
https://doi.org/10.1172/jci.insight.78210
https://doi.org/10.1172/jci.insight.78210
Autor:
Frank Revetta, Sarah P. Short, Amber Bradley, Utpal P. Davé, Pankaj Acharya, Christopher S. Williams, Stephen J. Brandt, Mukul K. Mittal, Kay Washington, Jennifer M. Pilat, M. Blanca Piazuelo, Scott W. Hiebert, Rachel E. Brown, Joshua J. Thompson, Niyati B. Vachharajani, Ken S. Lau, Shruti A. Anant, Bobak Parang, Noah F. Shroyer
Publikováno v:
Gastroenterology. 156:S-211
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b530295fdaa18d6a03a7b74c56a20e4
https://doi.org/10.1016/s0016-5085(19)37325-1
https://doi.org/10.1016/s0016-5085(19)37325-1
Publikováno v:
Archives of Biochemistry and Biophysics. 537:12-20
CYP2E1 plays a critical role in detoxification and carcinogenic activation of drugs, pollutants, and dietary compounds; however, these metabolic processes can involve poorly characterized cooperative interactions that compromise the ability to unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4befcd98c79586a64aac3eb539fce20
https://doi.org/10.1016/j.abb.2013.06.011
https://doi.org/10.1016/j.abb.2013.06.011
Autor:
Barbara Fingleton, Sean S. Davies, Amber Bradley, Bobak Parang, Elena Matafonova, Vishruth K. Reddy, Kshipra Singh, Raymond F. Burk, Mary K. Lintel, Caitlyn W. Barrett, Rupesh Chaturvedi, Amy K. Motley, Keith T. Wilson, Wei Ning, Kristina E. Hill, Mary Kay Washington, Shenika Poindexter, Christopher S. Williams
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67845 (2013)
PLoS ONE
PLoS ONE
Selenium (Se) is an essential micronutrient that exerts its functions via selenoproteins. Little is known about the role of Se in inflammatory bowel disease (IBD). Epidemiological studies have inversely correlated nutritional Se status with IBD sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131194f40a1b4991dc7586dd0ef14bdd
http://europepmc.org/articles/PMC3701622?pdf=render
http://europepmc.org/articles/PMC3701622?pdf=render
Autor:
David A. Schwartz, Keith T. Wilson, Amber Bradley, Caroline T. Brown, Dawn B. Beaulieu, Xi Chen, Elizabeth M. McDonough, Sandra S. Zinkel, Richard M. Peek, Yash A. Choksi, Scott W. Hiebert, Kshipra Singh, Rupesh Chaturvedi, Amanda D. Williams, Melissa A Fisher, Lori A. Coburn, Margaret M. Allaman, Sara N. Horst, Christopher S. Williams, Mary Kay Washington, Maria Blanca Piazuelo
Objective The myeloid translocation genes (MTGs) are transcriptional corepressors with both Mtg8 −/− and Mtgr1 −/− mice showing developmental and/or differentiation defects in the intestine. We sought to determine the role of MTG16 in intesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffb2c3e50f059d99dc1af7ecd92e2a0
https://europepmc.org/articles/PMC3663894/
https://europepmc.org/articles/PMC3663894/
