Výsledky vyhledávání - "Amber Blackmarr"

Akademický článek

Nonfucosylation of an anti-TIGIT antibody enhances FcγR engagement, driving innate immune activation and antitumor activity

Autor: Alyson J. Smith, Robert E. Thurman, Weiping Zeng, Bryan Grogan, Sasha Lucas, Guadalupe Gutierrez, Ryan A. Heiser, Serena W. Wo, Amber Blackmarr, Scott Peterson, Shyra J. Gardai

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

TIGIT is an immune checkpoint receptor expressed on activated and memory T cells, immunosuppressive T regulatory cells, and natural killer (NK) cells. TIGIT has emerged as an attractive target for antitumor therapies, due to its proposed immunosuppre

Externí odkaz: https://doaj.org/article/86e876dc1cba4ceab7a69a96d1671171

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250 SEA-TGT is a nonfucosylated antibody with distinct and amplified effector function activity that leverages the dependencies of anti-TIGIT anti-tumor activity upon Fc? R engagement

Autor: Scott Peterson, Robert Thurman, Alyson Smith, Amber Blackmarr, William Siegall, Bryan Grogan, Shyra Gardai, Jane Haass, Weiping Zeng

Publikováno v: Regular and young investigator award abstracts.

Background TIGIT is an immunoregulatory receptor expressed on activated and memory T cells, T regulatory cells (Tregs), and NK cells. TIGIT binding to CD155 and CD112 on tumor cells drives an inhibitory signal resulting in decreased T cell functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1627d383095530a60449889cb0a9a00e
https://doi.org/10.1136/jitc-2020-sitc2020.0250

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Abstract 1583: SEA-TGT is an empowered anti-TIGIT antibody that displays superior combinatorial activity with several therapeutic agents

Autor: Amber Blackmarr, Scott Peterson, Shyra Gardai, Alyson Smith, Serena Wo, Sasha Lucas, Weiping Zeng, Bryan Grogan

Publikováno v: Cancer Research. 81:1583-1583

TIGIT is an immunoregulatory receptor expressed on activated and memory T cells, Tregs, and NK cells. TIGIT binding to CD155 and CD112 on tumor cells drives an inhibitory signal resulting in decreased T cell functionality. TIGIT targeting has been re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07f363557198b74f0f69a0caf607c948
https://doi.org/10.1158/1538-7445.am2021-1583

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Abstract 4986: TIGIT directed human antibody modulates T-regulatory and effector cell function

Autor: Alyson Smith, Weiping Zeng, Bryan Grogan, Jane Haass, Amber Blackmarr, Scott Peterson, Shyra J. Gardai

Publikováno v: Cancer Research. 79:4986-4986

T-cell immune receptor with Ig and ITIM domains (TIGIT) is a receptor expressed on activated and memory T cells, immunosuppressive T regulatory cells (Tregs), and NK cells. Engagement with its ligands, CD155 and CD112, drives an inhibitory signal in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e976b563f8c9e8e460a69d45cd769af
https://doi.org/10.1158/1538-7445.am2019-4986

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